Efficacy of Supervised Pelvic Floor Muscle Training and Biofeedback Vs Attention-Control Treatment in Adults With Fecal Incontinence

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

BACKGROUND & AIMS: Pelvic floor muscle training (PFMT) in combination with conservative treatment is recommended as first-line treatment for patients with fecal incontinence, although its efficacy is unclear. We investigated whether supervised PFMT in combination with conservative treatment is superior to attention-control massage treatment and conservative treatment in adults with fecal incontinence.

METHODS: We performed a randomized, controlled, superiority trial of patients with fecal incontinence at a tertiary care center at a public hospital in Denmark. Ninety-eight adults with fecal incontinence were randomly assigned to groups that received supervised PFMT and biofeedback plus conservative treatment or attention-control treatment plus conservative treatment. The primary outcome was rating of symptom changes, after 16 weeks, based on scores from the Patient Global Impression of Improvement scale. Secondary outcomes were changes in the Vaizey incontinence score (Vaizey Score), Fecal Incontinence Severity Index, and Fecal Incontinence Quality of Life Scale.

RESULTS: In the intention-to-treat analysis, participants in the PFMT group were significantly more likely to report improvement in incontinence symptoms based on Patient Global Impression of Improvement scale scores (unadjusted odds ratio, 5.16; 95% CI, 2.18-12.19; P = .0002). The PFMT group had a larger reduction in the mean Vaizey Score (reduction, -1.83 points; 95% CI, -3.57 to -0.08; P = .04). There were no significant differences in condition-specific quality of life. In the per-protocol analyses, the superiority of PFMT was increased. No adverse events were reported.

CONCLUSIONS: In a randomized controlled trial of patients with fecal incontinence, we found that participants who received supervised PFMT had 5-fold higher odds of reporting improvements in fecal incontinence symptoms and had a larger mean reduction of incontinence severity based on the Vaizey Score. Clinicaltrials.gov no: NCT01705535.

OriginalsprogEngelsk
TidsskriftClinical Gastroenterology and Hepatology
Vol/bind17
Udgave nummer11
Sider (fra-til)2253-2261
ISSN1542-3565
DOI
StatusUdgivet - 2019

Bibliografisk note

Copyright © 2018 AGA Institute. Published by Elsevier Inc. All rights reserved.

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