Effectiveness of household lockable pesticide storage to reduce pesticide self-poisoning in rural Asia: a community-based, cluster-randomised controlled trial

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Standard

Effectiveness of household lockable pesticide storage to reduce pesticide self-poisoning in rural Asia : a community-based, cluster-randomised controlled trial. / Pearson, Melissa; Metcalfe, Chris; Jayamanne, Shaluka; Gunnell, David; Weerasinghe, Manjula; Pieris, Ravi; Priyadarshana, Chamil; Knipe, Duleeka W.; Hawton, Keith; Dawson, Andrew H.; Bandara, Palitha; DeSilva, Dhammika; Gawarammana, Indika; Eddleston, Michael; Konradsen, Flemming.

I: Lancet Oncology, Bind 390, Nr. 10105, 21.10.2017, s. 1863-1872.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Pearson, M, Metcalfe, C, Jayamanne, S, Gunnell, D, Weerasinghe, M, Pieris, R, Priyadarshana, C, Knipe, DW, Hawton, K, Dawson, AH, Bandara, P, DeSilva, D, Gawarammana, I, Eddleston, M & Konradsen, F 2017, 'Effectiveness of household lockable pesticide storage to reduce pesticide self-poisoning in rural Asia: a community-based, cluster-randomised controlled trial', Lancet Oncology, bind 390, nr. 10105, s. 1863-1872. https://doi.org/10.1016/S0140-6736(17)31961-X

APA

Pearson, M., Metcalfe, C., Jayamanne, S., Gunnell, D., Weerasinghe, M., Pieris, R., Priyadarshana, C., Knipe, D. W., Hawton, K., Dawson, A. H., Bandara, P., DeSilva, D., Gawarammana, I., Eddleston, M., & Konradsen, F. (2017). Effectiveness of household lockable pesticide storage to reduce pesticide self-poisoning in rural Asia: a community-based, cluster-randomised controlled trial. Lancet Oncology, 390(10105), 1863-1872. https://doi.org/10.1016/S0140-6736(17)31961-X

Vancouver

Pearson M, Metcalfe C, Jayamanne S, Gunnell D, Weerasinghe M, Pieris R o.a. Effectiveness of household lockable pesticide storage to reduce pesticide self-poisoning in rural Asia: a community-based, cluster-randomised controlled trial. Lancet Oncology. 2017 okt 21;390(10105):1863-1872. https://doi.org/10.1016/S0140-6736(17)31961-X

Author

Pearson, Melissa ; Metcalfe, Chris ; Jayamanne, Shaluka ; Gunnell, David ; Weerasinghe, Manjula ; Pieris, Ravi ; Priyadarshana, Chamil ; Knipe, Duleeka W. ; Hawton, Keith ; Dawson, Andrew H. ; Bandara, Palitha ; DeSilva, Dhammika ; Gawarammana, Indika ; Eddleston, Michael ; Konradsen, Flemming. / Effectiveness of household lockable pesticide storage to reduce pesticide self-poisoning in rural Asia : a community-based, cluster-randomised controlled trial. I: Lancet Oncology. 2017 ; Bind 390, Nr. 10105. s. 1863-1872.

Bibtex

@article{b3c2257716154aae8de5e333badfedd2,
title = "Effectiveness of household lockable pesticide storage to reduce pesticide self-poisoning in rural Asia: a community-based, cluster-randomised controlled trial",
abstract = "Background: Agricultural pesticide self-poisoning is a major public health problem in rural Asia. The use of safer household pesticide storage has been promoted to prevent deaths, but there is no evidence of effectiveness. We aimed to test the effectiveness of lockable household containers for prevention of pesticide self-poisoning.Methods: We did a community-based, cluster-randomised controlled trial in a rural area of North Central Province, Sri Lanka. Clusters of households were randomly assigned (1:1), with a sequence computer-generated by a minimisation process, to intervention or usual practice (control) groups. Intervention households that had farmed or had used or stored pesticide in the preceding agricultural season were given a lockable storage container. Further promotion of use of the containers was restricted to community posters and 6-monthly reminders during routine community meetings. The primary outcome was incidence of pesticide self-poisoning in people aged 14 years or older during 3 years of follow-up. Identification of outcome events was done by staff who were unaware of group allocation. Analysis was by intention to treat. This trial is registered with ClinicalTrials.gov, number NCT1146496.Findings: Between Dec 31, 2010, and Feb 2, 2013, we randomly assigned 90 rural villages to the intervention group and 90 to the control group. 27 091 households (114 168 individuals) in the intervention group and 26 291 households (109 693 individuals) in the control group consented to participate. 20 457 household pesticide storage containers were distributed. In individuals aged 14 years or older, 611 cases of pesticide self-poisoning had occurred by 3 years in the intervention group compared with 641 cases in the control group; incidence of pesticide self-poisoning did not differ between groups (293·3 per 100 000 person-years of follow-up in the intervention group vs 318·0 per 100 000 in the control group; rate ratio [RR] 0·93, 95% CI 0·80–1·08; p=0·33). We found no evidence of switching from pesticide self-poisoning to other forms of self-harm, with no significant difference in the number of fatal (82 in the intervention group vs 67 in the control group; RR 1·22, 0·88–1·68]) or non-fatal (1135 vs 1153; RR 0·97, 0·86–1·08) self-harm events involving all methods.Interpretation: We found no evidence that means reduction through improved household pesticide storage reduces pesticide self-poisoning. Other approaches, particularly removal of highly hazardous pesticides from agricultural practice, are likely to be more effective for suicide prevention in rural Asia.Funding: Wellcome Trust, with additional support from the American Foundation for Suicide Prevention, Lister Institute of Preventive Medicine, Chief Scientist Office of Scotland, University of Copenhagen, and NHMRC Australia.",
author = "Melissa Pearson and Chris Metcalfe and Shaluka Jayamanne and David Gunnell and Manjula Weerasinghe and Ravi Pieris and Chamil Priyadarshana and Knipe, {Duleeka W.} and Keith Hawton and Dawson, {Andrew H.} and Palitha Bandara and Dhammika DeSilva and Indika Gawarammana and Michael Eddleston and Flemming Konradsen",
year = "2017",
month = oct,
day = "21",
doi = "10.1016/S0140-6736(17)31961-X",
language = "English",
volume = "390",
pages = "1863--1872",
journal = "Lancet Oncology",
issn = "1470-2045",
publisher = "TheLancet Publishing Group",
number = "10105",

}

RIS

TY - JOUR

T1 - Effectiveness of household lockable pesticide storage to reduce pesticide self-poisoning in rural Asia

T2 - a community-based, cluster-randomised controlled trial

AU - Pearson, Melissa

AU - Metcalfe, Chris

AU - Jayamanne, Shaluka

AU - Gunnell, David

AU - Weerasinghe, Manjula

AU - Pieris, Ravi

AU - Priyadarshana, Chamil

AU - Knipe, Duleeka W.

AU - Hawton, Keith

AU - Dawson, Andrew H.

AU - Bandara, Palitha

AU - DeSilva, Dhammika

AU - Gawarammana, Indika

AU - Eddleston, Michael

AU - Konradsen, Flemming

PY - 2017/10/21

Y1 - 2017/10/21

N2 - Background: Agricultural pesticide self-poisoning is a major public health problem in rural Asia. The use of safer household pesticide storage has been promoted to prevent deaths, but there is no evidence of effectiveness. We aimed to test the effectiveness of lockable household containers for prevention of pesticide self-poisoning.Methods: We did a community-based, cluster-randomised controlled trial in a rural area of North Central Province, Sri Lanka. Clusters of households were randomly assigned (1:1), with a sequence computer-generated by a minimisation process, to intervention or usual practice (control) groups. Intervention households that had farmed or had used or stored pesticide in the preceding agricultural season were given a lockable storage container. Further promotion of use of the containers was restricted to community posters and 6-monthly reminders during routine community meetings. The primary outcome was incidence of pesticide self-poisoning in people aged 14 years or older during 3 years of follow-up. Identification of outcome events was done by staff who were unaware of group allocation. Analysis was by intention to treat. This trial is registered with ClinicalTrials.gov, number NCT1146496.Findings: Between Dec 31, 2010, and Feb 2, 2013, we randomly assigned 90 rural villages to the intervention group and 90 to the control group. 27 091 households (114 168 individuals) in the intervention group and 26 291 households (109 693 individuals) in the control group consented to participate. 20 457 household pesticide storage containers were distributed. In individuals aged 14 years or older, 611 cases of pesticide self-poisoning had occurred by 3 years in the intervention group compared with 641 cases in the control group; incidence of pesticide self-poisoning did not differ between groups (293·3 per 100 000 person-years of follow-up in the intervention group vs 318·0 per 100 000 in the control group; rate ratio [RR] 0·93, 95% CI 0·80–1·08; p=0·33). We found no evidence of switching from pesticide self-poisoning to other forms of self-harm, with no significant difference in the number of fatal (82 in the intervention group vs 67 in the control group; RR 1·22, 0·88–1·68]) or non-fatal (1135 vs 1153; RR 0·97, 0·86–1·08) self-harm events involving all methods.Interpretation: We found no evidence that means reduction through improved household pesticide storage reduces pesticide self-poisoning. Other approaches, particularly removal of highly hazardous pesticides from agricultural practice, are likely to be more effective for suicide prevention in rural Asia.Funding: Wellcome Trust, with additional support from the American Foundation for Suicide Prevention, Lister Institute of Preventive Medicine, Chief Scientist Office of Scotland, University of Copenhagen, and NHMRC Australia.

AB - Background: Agricultural pesticide self-poisoning is a major public health problem in rural Asia. The use of safer household pesticide storage has been promoted to prevent deaths, but there is no evidence of effectiveness. We aimed to test the effectiveness of lockable household containers for prevention of pesticide self-poisoning.Methods: We did a community-based, cluster-randomised controlled trial in a rural area of North Central Province, Sri Lanka. Clusters of households were randomly assigned (1:1), with a sequence computer-generated by a minimisation process, to intervention or usual practice (control) groups. Intervention households that had farmed or had used or stored pesticide in the preceding agricultural season were given a lockable storage container. Further promotion of use of the containers was restricted to community posters and 6-monthly reminders during routine community meetings. The primary outcome was incidence of pesticide self-poisoning in people aged 14 years or older during 3 years of follow-up. Identification of outcome events was done by staff who were unaware of group allocation. Analysis was by intention to treat. This trial is registered with ClinicalTrials.gov, number NCT1146496.Findings: Between Dec 31, 2010, and Feb 2, 2013, we randomly assigned 90 rural villages to the intervention group and 90 to the control group. 27 091 households (114 168 individuals) in the intervention group and 26 291 households (109 693 individuals) in the control group consented to participate. 20 457 household pesticide storage containers were distributed. In individuals aged 14 years or older, 611 cases of pesticide self-poisoning had occurred by 3 years in the intervention group compared with 641 cases in the control group; incidence of pesticide self-poisoning did not differ between groups (293·3 per 100 000 person-years of follow-up in the intervention group vs 318·0 per 100 000 in the control group; rate ratio [RR] 0·93, 95% CI 0·80–1·08; p=0·33). We found no evidence of switching from pesticide self-poisoning to other forms of self-harm, with no significant difference in the number of fatal (82 in the intervention group vs 67 in the control group; RR 1·22, 0·88–1·68]) or non-fatal (1135 vs 1153; RR 0·97, 0·86–1·08) self-harm events involving all methods.Interpretation: We found no evidence that means reduction through improved household pesticide storage reduces pesticide self-poisoning. Other approaches, particularly removal of highly hazardous pesticides from agricultural practice, are likely to be more effective for suicide prevention in rural Asia.Funding: Wellcome Trust, with additional support from the American Foundation for Suicide Prevention, Lister Institute of Preventive Medicine, Chief Scientist Office of Scotland, University of Copenhagen, and NHMRC Australia.

U2 - 10.1016/S0140-6736(17)31961-X

DO - 10.1016/S0140-6736(17)31961-X

M3 - Journal article

VL - 390

SP - 1863

EP - 1872

JO - Lancet Oncology

JF - Lancet Oncology

SN - 1470-2045

IS - 10105

ER -

ID: 185846513