Effect of induced chronic atrial fibrillation on exercise performance in Standardbred trotters

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Standard

Effect of induced chronic atrial fibrillation on exercise performance in Standardbred trotters. / Buhl, Rikke; Carstensen, Helena; Hesselkilde, Eva Zander; Klein, Bjørg Zinkernagel; Hougaard, Karen Margrethe; Ravn, Kirsten Bomberg; Loft-Andersen, Ameli Victoria; Fenner, Merle Friederike; Pipper, Christian; Jespersen, Thomas.

I: Journal of Veterinary Internal Medicine, Bind 32, Nr. 4, 2018, s. 1410-1419.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Buhl, R, Carstensen, H, Hesselkilde, EZ, Klein, BZ, Hougaard, KM, Ravn, KB, Loft-Andersen, AV, Fenner, MF, Pipper, C & Jespersen, T 2018, 'Effect of induced chronic atrial fibrillation on exercise performance in Standardbred trotters', Journal of Veterinary Internal Medicine, bind 32, nr. 4, s. 1410-1419. https://doi.org/10.1111/jvim.15137

APA

Buhl, R., Carstensen, H., Hesselkilde, E. Z., Klein, B. Z., Hougaard, K. M., Ravn, K. B., ... Jespersen, T. (2018). Effect of induced chronic atrial fibrillation on exercise performance in Standardbred trotters. Journal of Veterinary Internal Medicine, 32(4), 1410-1419. https://doi.org/10.1111/jvim.15137

Vancouver

Buhl R, Carstensen H, Hesselkilde EZ, Klein BZ, Hougaard KM, Ravn KB o.a. Effect of induced chronic atrial fibrillation on exercise performance in Standardbred trotters. Journal of Veterinary Internal Medicine. 2018;32(4):1410-1419. https://doi.org/10.1111/jvim.15137

Author

Buhl, Rikke ; Carstensen, Helena ; Hesselkilde, Eva Zander ; Klein, Bjørg Zinkernagel ; Hougaard, Karen Margrethe ; Ravn, Kirsten Bomberg ; Loft-Andersen, Ameli Victoria ; Fenner, Merle Friederike ; Pipper, Christian ; Jespersen, Thomas. / Effect of induced chronic atrial fibrillation on exercise performance in Standardbred trotters. I: Journal of Veterinary Internal Medicine. 2018 ; Bind 32, Nr. 4. s. 1410-1419.

Bibtex

@article{bbd313487c4e4b74abbb2bc22015245c,
title = "Effect of induced chronic atrial fibrillation on exercise performance in Standardbred trotters",
abstract = "Background: Atrial fibrillation (AF) is the most common arrhythmia affecting performance in horses. However, no previous studies have quantified the performance reduction in horses suffering from AF. Objectives: To quantify the effect of AF on maximum velocity (Vmax), maximum heart rate (HRmax), heart rate recovery (T100), hematologic parameters and development of abnormal QRS complexes. Animals: Nine Standardbred trotters. Methods: Two-arm controlled trial. Six horses had AF induced by means of a pacemaker and 3 served as sham-operated controls. All horses were subjected to an exercise test to fatigue before (SET1) and after (SET2) 2 months of AF or sham. The Vmax and HRmax were assessed using a linear mixed normal model. Abnormal QRS complexes were counted manually on surface ECGs. Results: Atrial fibrillation resulted in a 1.56 m/sec decrease in Vmax (P <.0001). In the AF group, HRmax ± SD increased from 226 ± 11 bpm at SET1 to 311 ± 27 bpm at SET 2. The AF group had higher HRmax at SET2 compared with controls (P <.0001), whereas no difference between the control and AF groups was observed at SET1 (P =.96). Several episodes of wide complex tachycardia were observed during exercise in 3 of the AF horses during SET2. Conclusions and Clinical Importance: Atrial fibrillation resulted in a significant reduction in performance, an increase in HR and development of abnormal QRS complexes during exercise, which may be a risk factor for collapse or sudden cardiac death.",
keywords = "arrhythmia, atrial fibrillation, cardiology, exercise, heart rate, horse, performance",
author = "Rikke Buhl and Helena Carstensen and Hesselkilde, {Eva Zander} and Klein, {Bj{\o}rg Zinkernagel} and Hougaard, {Karen Margrethe} and Ravn, {Kirsten Bomberg} and Loft-Andersen, {Ameli Victoria} and Fenner, {Merle Friederike} and Christian Pipper and Thomas Jespersen",
year = "2018",
doi = "10.1111/jvim.15137",
language = "English",
volume = "32",
pages = "1410--1419",
journal = "Journal of Veterinary Internal Medicine",
issn = "0891-6640",
publisher = "Wiley-Blackwell",
number = "4",

}

RIS

TY - JOUR

T1 - Effect of induced chronic atrial fibrillation on exercise performance in Standardbred trotters

AU - Buhl, Rikke

AU - Carstensen, Helena

AU - Hesselkilde, Eva Zander

AU - Klein, Bjørg Zinkernagel

AU - Hougaard, Karen Margrethe

AU - Ravn, Kirsten Bomberg

AU - Loft-Andersen, Ameli Victoria

AU - Fenner, Merle Friederike

AU - Pipper, Christian

AU - Jespersen, Thomas

PY - 2018

Y1 - 2018

N2 - Background: Atrial fibrillation (AF) is the most common arrhythmia affecting performance in horses. However, no previous studies have quantified the performance reduction in horses suffering from AF. Objectives: To quantify the effect of AF on maximum velocity (Vmax), maximum heart rate (HRmax), heart rate recovery (T100), hematologic parameters and development of abnormal QRS complexes. Animals: Nine Standardbred trotters. Methods: Two-arm controlled trial. Six horses had AF induced by means of a pacemaker and 3 served as sham-operated controls. All horses were subjected to an exercise test to fatigue before (SET1) and after (SET2) 2 months of AF or sham. The Vmax and HRmax were assessed using a linear mixed normal model. Abnormal QRS complexes were counted manually on surface ECGs. Results: Atrial fibrillation resulted in a 1.56 m/sec decrease in Vmax (P <.0001). In the AF group, HRmax ± SD increased from 226 ± 11 bpm at SET1 to 311 ± 27 bpm at SET 2. The AF group had higher HRmax at SET2 compared with controls (P <.0001), whereas no difference between the control and AF groups was observed at SET1 (P =.96). Several episodes of wide complex tachycardia were observed during exercise in 3 of the AF horses during SET2. Conclusions and Clinical Importance: Atrial fibrillation resulted in a significant reduction in performance, an increase in HR and development of abnormal QRS complexes during exercise, which may be a risk factor for collapse or sudden cardiac death.

AB - Background: Atrial fibrillation (AF) is the most common arrhythmia affecting performance in horses. However, no previous studies have quantified the performance reduction in horses suffering from AF. Objectives: To quantify the effect of AF on maximum velocity (Vmax), maximum heart rate (HRmax), heart rate recovery (T100), hematologic parameters and development of abnormal QRS complexes. Animals: Nine Standardbred trotters. Methods: Two-arm controlled trial. Six horses had AF induced by means of a pacemaker and 3 served as sham-operated controls. All horses were subjected to an exercise test to fatigue before (SET1) and after (SET2) 2 months of AF or sham. The Vmax and HRmax were assessed using a linear mixed normal model. Abnormal QRS complexes were counted manually on surface ECGs. Results: Atrial fibrillation resulted in a 1.56 m/sec decrease in Vmax (P <.0001). In the AF group, HRmax ± SD increased from 226 ± 11 bpm at SET1 to 311 ± 27 bpm at SET 2. The AF group had higher HRmax at SET2 compared with controls (P <.0001), whereas no difference between the control and AF groups was observed at SET1 (P =.96). Several episodes of wide complex tachycardia were observed during exercise in 3 of the AF horses during SET2. Conclusions and Clinical Importance: Atrial fibrillation resulted in a significant reduction in performance, an increase in HR and development of abnormal QRS complexes during exercise, which may be a risk factor for collapse or sudden cardiac death.

KW - arrhythmia

KW - atrial fibrillation

KW - cardiology

KW - exercise

KW - heart rate

KW - horse

KW - performance

U2 - 10.1111/jvim.15137

DO - 10.1111/jvim.15137

M3 - Journal article

C2 - 29749082

AN - SCOPUS:85046769601

VL - 32

SP - 1410

EP - 1419

JO - Journal of Veterinary Internal Medicine

JF - Journal of Veterinary Internal Medicine

SN - 0891-6640

IS - 4

ER -

ID: 203674497