Early-onset atrial fibrillation patients show reduced left ventricular ejection fraction and increased atrial fibrosis
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Early-onset atrial fibrillation patients show reduced left ventricular ejection fraction and increased atrial fibrosis. / Andreasen, Laura; Bertelsen, Litten; Ghouse, Jonas; Lundegaard, Pia R.; Ahlberg, Gustav; Refsgaard, Lena; Rasmussen, Torsten B.; Eiskjær, Hans; Haunsø, Stig; Vejlstrup, Niels; Svendsen, Jesper H.; Olesen, Morten S.
I: Scientific Reports, Bind 10, Nr. 1, 10039, 2020.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - Early-onset atrial fibrillation patients show reduced left ventricular ejection fraction and increased atrial fibrosis
AU - Andreasen, Laura
AU - Bertelsen, Litten
AU - Ghouse, Jonas
AU - Lundegaard, Pia R.
AU - Ahlberg, Gustav
AU - Refsgaard, Lena
AU - Rasmussen, Torsten B.
AU - Eiskjær, Hans
AU - Haunsø, Stig
AU - Vejlstrup, Niels
AU - Svendsen, Jesper H.
AU - Olesen, Morten S.
PY - 2020
Y1 - 2020
N2 - Atrial fibrillation (AF) has traditionally been considered an electrical heart disease. However, genetic studies have revealed that the structural architecture of the heart also play a significant role. We evaluated the functional and structural consequences of harboring a titin-truncating variant (TTNtv) in AF patients, using cardiac magnetic resonance (CMR). Seventeen early-onset AF cases carrying a TTNtv, were matched 1:1 with non-AF controls and a replication cohort of early-onset AF cases without TTNtv, and underwent CMR. Cardiac volumes and left atrial late gadolinium enhancement (LA LGE), as a fibrosis proxy, were measured by a blinded operator. Results: AF cases with TTNtv had significantly reduced left ventricular ejection fraction (LVEF) compared with controls (57 ± 4 vs 64 ± 5%, P < 0.001). We obtained similar findings in early-onset AF patients without TTNtv compared with controls (61 ± 4 vs 64 ± 5%, P = 0.02). We furthermore found a statistically significant increase in LA LGE when comparing early-onset AF TTNtv cases with controls. Using state-of-the-art CMR, we found that early-onset AF patients, irrespective of TTNtv carrier status, had reduced LVEF, indicating that early-onset AF might not be as benign as previously thought.
AB - Atrial fibrillation (AF) has traditionally been considered an electrical heart disease. However, genetic studies have revealed that the structural architecture of the heart also play a significant role. We evaluated the functional and structural consequences of harboring a titin-truncating variant (TTNtv) in AF patients, using cardiac magnetic resonance (CMR). Seventeen early-onset AF cases carrying a TTNtv, were matched 1:1 with non-AF controls and a replication cohort of early-onset AF cases without TTNtv, and underwent CMR. Cardiac volumes and left atrial late gadolinium enhancement (LA LGE), as a fibrosis proxy, were measured by a blinded operator. Results: AF cases with TTNtv had significantly reduced left ventricular ejection fraction (LVEF) compared with controls (57 ± 4 vs 64 ± 5%, P < 0.001). We obtained similar findings in early-onset AF patients without TTNtv compared with controls (61 ± 4 vs 64 ± 5%, P = 0.02). We furthermore found a statistically significant increase in LA LGE when comparing early-onset AF TTNtv cases with controls. Using state-of-the-art CMR, we found that early-onset AF patients, irrespective of TTNtv carrier status, had reduced LVEF, indicating that early-onset AF might not be as benign as previously thought.
UR - http://www.scopus.com/inward/record.url?scp=85086705461&partnerID=8YFLogxK
U2 - 10.1038/s41598-020-66671-w
DO - 10.1038/s41598-020-66671-w
M3 - Journal article
C2 - 32572052
AN - SCOPUS:85086705461
VL - 10
JO - Scientific Reports
JF - Scientific Reports
SN - 2045-2322
IS - 1
M1 - 10039
ER -
ID: 244609219