Dynamic Cerebral Autoregulation Is Maintained during High-Intensity Interval Exercise
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Dynamic Cerebral Autoregulation Is Maintained during High-Intensity Interval Exercise. / Tsukamoto, Hayato; Hashimoto, Takeshi; Olesen, Niels D; Petersen, Lonnie G; Sørensen, Henrik; Nielsen, Henning B; Secher, Niels H; Ogoh, Shigehiko.
I: Medicine and Science in Sports and Exercise, Bind 51, Nr. 2, 02.2019, s. 372-378.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Dynamic Cerebral Autoregulation Is Maintained during High-Intensity Interval Exercise
AU - Tsukamoto, Hayato
AU - Hashimoto, Takeshi
AU - Olesen, Niels D
AU - Petersen, Lonnie G
AU - Sørensen, Henrik
AU - Nielsen, Henning B
AU - Secher, Niels H
AU - Ogoh, Shigehiko
PY - 2019/2
Y1 - 2019/2
N2 - INTRODUCTION: High-intensity interval exercise (HIIE) is more effective at increasing metabolic and cardiovascular health compared with moderate-intensity continuous exercise for patients with cardiovascular disease, but exhaustive high-intensity continuous exercise attenuates dynamic cerebral autoregulation (CA). This study assessed the effect of HIIE on dynamic CA.METHODS: Nine healthy men (age, 24 ± 3 yr; mean ± SD) warmed up at 50%-60% maximal workload (Wmax) for 5 min before HIIE including four 4-min bouts of exercise at 80%-90% Wmax interspaced by four 3-min bouts at 50% to 60% Wmax. Transcranial Doppler determined middle cerebral artery mean blood velocity (MCA Vmean), and brachial artery catheterization determined mean arterial pressure (MAP). Dynamic CA was evaluated by transfer function analysis of changes in MAP and MCA Vmean.RESULTS: The HIIE increased MAP (from 92 ± 9 to 104 ± 10 mm Hg; P < 0.0125), whereas MCA Vmean did not change. Transfer function phase increased and coherence decreased during HIIE (P < 0.0125 vs rest, respectively), whereas gain was unchanged.CONCLUSIONS: The results suggest that dynamic CA is unaffected during HIIE, indicating that the brain is protected from fluctuations in MAP. Thus, we propose that HIIE may be beneficial for brain-related health as maintenance of cerebral perfusion in contrast to high-intensity continuous exercise.
AB - INTRODUCTION: High-intensity interval exercise (HIIE) is more effective at increasing metabolic and cardiovascular health compared with moderate-intensity continuous exercise for patients with cardiovascular disease, but exhaustive high-intensity continuous exercise attenuates dynamic cerebral autoregulation (CA). This study assessed the effect of HIIE on dynamic CA.METHODS: Nine healthy men (age, 24 ± 3 yr; mean ± SD) warmed up at 50%-60% maximal workload (Wmax) for 5 min before HIIE including four 4-min bouts of exercise at 80%-90% Wmax interspaced by four 3-min bouts at 50% to 60% Wmax. Transcranial Doppler determined middle cerebral artery mean blood velocity (MCA Vmean), and brachial artery catheterization determined mean arterial pressure (MAP). Dynamic CA was evaluated by transfer function analysis of changes in MAP and MCA Vmean.RESULTS: The HIIE increased MAP (from 92 ± 9 to 104 ± 10 mm Hg; P < 0.0125), whereas MCA Vmean did not change. Transfer function phase increased and coherence decreased during HIIE (P < 0.0125 vs rest, respectively), whereas gain was unchanged.CONCLUSIONS: The results suggest that dynamic CA is unaffected during HIIE, indicating that the brain is protected from fluctuations in MAP. Thus, we propose that HIIE may be beneficial for brain-related health as maintenance of cerebral perfusion in contrast to high-intensity continuous exercise.
KW - Adult
KW - Blood Flow Velocity
KW - Blood Pressure
KW - Brachial Artery/physiology
KW - Brain/blood supply
KW - Cerebrovascular Circulation
KW - High-Intensity Interval Training/psychology
KW - Homeostasis
KW - Humans
KW - Male
KW - Middle Cerebral Artery/physiology
KW - Perception
KW - Physical Exertion
KW - Ultrasonography, Doppler, Transcranial
KW - Young Adult
U2 - 10.1249/MSS.0000000000001792
DO - 10.1249/MSS.0000000000001792
M3 - Journal article
C2 - 30252775
VL - 51
SP - 372
EP - 378
JO - Medicine and Science in Sports and Exercise
JF - Medicine and Science in Sports and Exercise
SN - 0195-9131
IS - 2
ER -
ID: 227346375