Drug Target Commons: A Community Effort to Build a Consensus Knowledge Base for Drug-Target Interactions

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

  • Jing Tang
  • Zia-Ur-Rehman Tanoli
  • Balaguru Ravikumar
  • Zaid Alam
  • Anni Rebane
  • Markus Vähä-Koskela
  • Gopal Peddinti
  • Arjan J van Adrichem
  • Janica Wakkinen
  • Alok Jaiswal
  • Ella Karjalainen
  • Prson Gautam
  • Liye He
  • Elina Parri
  • Suleiman Khan
  • Abhishekh Gupta
  • Mehreen Ali
  • Laxman Yetukuri
  • Anna-Lena Gustavsson
  • Brinton Seashore-Ludlow
  • Anne Hersey
  • Andrew R Leach
  • John P Overington
  • Gretchen Repasky
  • Tero Aittokallio

Knowledge of the full target space of bioactive substances, approved and investigational drugs as well as chemical probes, provides important insights into therapeutic potential and possible adverse effects. The existing compound-target bioactivity data resources are often incomparable due to non-standardized and heterogeneous assay types and variability in endpoint measurements. To extract higher value from the existing and future compound target-profiling data, we implemented an open-data web platform, named Drug Target Commons (DTC), which features tools for crowd-sourced compound-target bioactivity data annotation, standardization, curation, and intra-resource integration. We demonstrate the unique value of DTC with several examples related to both drug discovery and drug repurposing applications and invite researchers to join this community effort to increase the reuse and extension of compound bioactivity data.

TidsskriftCell Chemical Biology
Udgave nummer2
Sider (fra-til)224-229.e2
StatusUdgivet - 15 feb. 2018
Eksternt udgivetJa

ID: 199421896