DNA methylation in blood cells is associated with cortisol levels in offspring of mothers who had prenatal post-traumatic stress disorder
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Dokumenter
- Fulltext
Forlagets udgivne version, 580 KB, PDF-dokument
Maternal stress during pregnancy is associated with differential DNA methylation in offspring and disrupted cortisol secretion. This study aimed to determine methylation signatures of cortisol levels in children, and whether associations differ based on maternal post-traumatic stress disorder (PTSD). Blood epigenome-wide methylation and fasting cortisol levels were measured in 118 offspring of mothers recruited from the Kosovo Rehabilitation Centre for Torture Victims. Mothers underwent clinically administered assessment for PTSD using Diagnostic and Statistical Manual of Mental Disorders. Correlations between offspring methylation and cortisol levels were examined using epigenome-wide analysis, adjusting for covariates. Subsequent analysis focussed on a priori selected genes involved in the hypothalamic–pituitary–adrenal (HPA) axis stress signalling. Methylation at four sites were correlated with cortisol levels (cg15321696, r = −0.33, cg18105800, r = +0.33, cg00986889, r = −0.25, and cg15920527, r = −0.27). In adjusted multivariable regression, when stratifying based on prenatal PTSD status, significant associations were only found for children born to mothers with prenatal PTSD (p < 0.001). Several sites within HPA axis genes were also associated with cortisol levels in the maternal PTSD group specifically. There is evidence that methylation is associated with cortisol levels, particularly in offspring born to mothers with prenatal PTSD. However, larger studies need to be carried out to independently validate these findings.
Originalsprog | Engelsk |
---|---|
Tidsskrift | Stress and Health |
Vol/bind | 38 |
Udgave nummer | 4 |
Sider (fra-til) | 755-766 |
Antal sider | 12 |
ISSN | 1532-3005 |
DOI | |
Status | Udgivet - 2022 |
Bibliografisk note
Funding Information:
This study was funded by the Foreign, Commonwealth and Development Office through the British Embassy in Pristina and the Danish Institute against Torture (Denmark). L. Hjort is funded by the Danish Diabetes Academy supported by the Novo Nordisk Foundation. J. Ryan is supported by a National Health and Medical Research Council Research Leader Fellowship (grant no.: 1135727). The contents of this publication are the sole responsibility of the authors and do not necessarily reflect the views of the Foreign, Commonwealth and Development Office. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.
Publisher Copyright:
© 2022 The Authors. Stress and Health published by John Wiley & Sons Ltd.
Antal downloads er baseret på statistik fra Google Scholar og www.ku.dk
ID: 298645356