Divergent Roles of α5 and β4 Nicotinic Receptor Subunits in Food Reward and Nicotine-induced Weight Loss in Male Mice

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Standard

Divergent Roles of α5 and β4 Nicotinic Receptor Subunits in Food Reward and Nicotine-induced Weight Loss in Male Mice. / Breum, Alberte Wollesen; Falk, Sarah; Svendsen, Charlotte Sashi Aier; Nicolaisen, Trine Sand; Mathiesen, Cecilie Vad; Maskos, Uwe; Clemmensen, Christoffer.

I: Endocrinology, Bind 163, Nr. 7, bqac079, 2022.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Breum, AW, Falk, S, Svendsen, CSA, Nicolaisen, TS, Mathiesen, CV, Maskos, U & Clemmensen, C 2022, 'Divergent Roles of α5 and β4 Nicotinic Receptor Subunits in Food Reward and Nicotine-induced Weight Loss in Male Mice', Endocrinology, bind 163, nr. 7, bqac079. https://doi.org/10.1210/endocr/bqac079

APA

Breum, A. W., Falk, S., Svendsen, C. S. A., Nicolaisen, T. S., Mathiesen, C. V., Maskos, U., & Clemmensen, C. (2022). Divergent Roles of α5 and β4 Nicotinic Receptor Subunits in Food Reward and Nicotine-induced Weight Loss in Male Mice. Endocrinology, 163(7), [bqac079]. https://doi.org/10.1210/endocr/bqac079

Vancouver

Breum AW, Falk S, Svendsen CSA, Nicolaisen TS, Mathiesen CV, Maskos U o.a. Divergent Roles of α5 and β4 Nicotinic Receptor Subunits in Food Reward and Nicotine-induced Weight Loss in Male Mice. Endocrinology. 2022;163(7). bqac079. https://doi.org/10.1210/endocr/bqac079

Author

Breum, Alberte Wollesen ; Falk, Sarah ; Svendsen, Charlotte Sashi Aier ; Nicolaisen, Trine Sand ; Mathiesen, Cecilie Vad ; Maskos, Uwe ; Clemmensen, Christoffer. / Divergent Roles of α5 and β4 Nicotinic Receptor Subunits in Food Reward and Nicotine-induced Weight Loss in Male Mice. I: Endocrinology. 2022 ; Bind 163, Nr. 7.

Bibtex

@article{af5d34cdf4664b5d871bfc4b48ec4ae0,
title = "Divergent Roles of α5 and β4 Nicotinic Receptor Subunits in Food Reward and Nicotine-induced Weight Loss in Male Mice",
abstract = "A major obstacle to successful smoking cessation is the prospect of weight gain. Despite a clear relationship between cigarette smoking and body weight, surprisingly little is known about the physiological and molecular mechanism by which nicotine affects energy homeostasis and food-motivated behaviors. Here we use loss-of-function mouse models to demonstrate that 2 nicotinic acetylcholine receptor (nAChR) subunits encoded by the CHRNA5-CHRNA3-CHRNB4 gene cluster, α5 and β4, exhibit divergent roles in food reward. We also reveal that β4-containing nAChRs are essential for the weight-lowering effects of nicotine in diet-induced obese mice. Finally, our data support the notion of crosstalk between incretin biology and nAChR signaling, as we demonstrate that the glycemic benefits of glucagon-like peptide-1 receptor activation partially relies on β4-containing nAChRs. Together, these data encourage further research into the role of cholinergic neurotransmission in regulating food reward and the translational pursuit of site-directed targeting of β4-containing nAChRs for treatment of metabolic disease. ",
keywords = "body weight, Metabolism, nAChR, Nicotine, Nicotinic receptor, Reward",
author = "Breum, {Alberte Wollesen} and Sarah Falk and Svendsen, {Charlotte Sashi Aier} and Nicolaisen, {Trine Sand} and Mathiesen, {Cecilie Vad} and Uwe Maskos and Christoffer Clemmensen",
note = "Publisher Copyright: {\textcopyright} 2022 The Author(s). Published by Oxford University Press on behalf of the Endocrine Society.",
year = "2022",
doi = "10.1210/endocr/bqac079",
language = "English",
volume = "163",
journal = "Journal of Clinical Endocrinology and Metabolism",
issn = "0013-7227",
publisher = "Oxford University Press",
number = "7",

}

RIS

TY - JOUR

T1 - Divergent Roles of α5 and β4 Nicotinic Receptor Subunits in Food Reward and Nicotine-induced Weight Loss in Male Mice

AU - Breum, Alberte Wollesen

AU - Falk, Sarah

AU - Svendsen, Charlotte Sashi Aier

AU - Nicolaisen, Trine Sand

AU - Mathiesen, Cecilie Vad

AU - Maskos, Uwe

AU - Clemmensen, Christoffer

N1 - Publisher Copyright: © 2022 The Author(s). Published by Oxford University Press on behalf of the Endocrine Society.

PY - 2022

Y1 - 2022

N2 - A major obstacle to successful smoking cessation is the prospect of weight gain. Despite a clear relationship between cigarette smoking and body weight, surprisingly little is known about the physiological and molecular mechanism by which nicotine affects energy homeostasis and food-motivated behaviors. Here we use loss-of-function mouse models to demonstrate that 2 nicotinic acetylcholine receptor (nAChR) subunits encoded by the CHRNA5-CHRNA3-CHRNB4 gene cluster, α5 and β4, exhibit divergent roles in food reward. We also reveal that β4-containing nAChRs are essential for the weight-lowering effects of nicotine in diet-induced obese mice. Finally, our data support the notion of crosstalk between incretin biology and nAChR signaling, as we demonstrate that the glycemic benefits of glucagon-like peptide-1 receptor activation partially relies on β4-containing nAChRs. Together, these data encourage further research into the role of cholinergic neurotransmission in regulating food reward and the translational pursuit of site-directed targeting of β4-containing nAChRs for treatment of metabolic disease.

AB - A major obstacle to successful smoking cessation is the prospect of weight gain. Despite a clear relationship between cigarette smoking and body weight, surprisingly little is known about the physiological and molecular mechanism by which nicotine affects energy homeostasis and food-motivated behaviors. Here we use loss-of-function mouse models to demonstrate that 2 nicotinic acetylcholine receptor (nAChR) subunits encoded by the CHRNA5-CHRNA3-CHRNB4 gene cluster, α5 and β4, exhibit divergent roles in food reward. We also reveal that β4-containing nAChRs are essential for the weight-lowering effects of nicotine in diet-induced obese mice. Finally, our data support the notion of crosstalk between incretin biology and nAChR signaling, as we demonstrate that the glycemic benefits of glucagon-like peptide-1 receptor activation partially relies on β4-containing nAChRs. Together, these data encourage further research into the role of cholinergic neurotransmission in regulating food reward and the translational pursuit of site-directed targeting of β4-containing nAChRs for treatment of metabolic disease.

KW - body weight

KW - Metabolism

KW - nAChR

KW - Nicotine

KW - Nicotinic receptor

KW - Reward

U2 - 10.1210/endocr/bqac079

DO - 10.1210/endocr/bqac079

M3 - Journal article

C2 - 35595472

AN - SCOPUS:85133707093

VL - 163

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0013-7227

IS - 7

M1 - bqac079

ER -

ID: 314441432