TY - JOUR

T1 - Dietary intake, FTO genetic variants and adiposity

T2 - a combined analysis of over 16,000 children and adolescents

AU - Qi, Qibin

AU - Downer, Mary K

AU - Oskari Kilpeläinen, Tuomas

AU - Taal, H Rob

AU - Barton, Sheila J

AU - Ntalla, Ioanna

AU - Standl, Marie

AU - Boraska, Vesna

AU - Huikari, Ville

AU - Kiefte-de Jong, Jessica C

AU - Körner, Antje

AU - Lakka, Timo A

AU - Liu, Gaifen

AU - Magnusson, Jessica

AU - Okuda, Masayuki

AU - Raitakari, Olli

AU - Richmond, Rebecca

AU - Scott, Robert A

AU - Bailey, Mark E S

AU - Scheuermann, Kathrin

AU - Holloway, John W

AU - Inskip, Hazel

AU - Isasi, Carmen R

AU - Mossavar-Rahmani, Yasmin

AU - Jaddoe, Vincent W V

AU - Laitinen, Jaana

AU - Lindi, Virpi

AU - Melén, Erik

AU - Pitsiladis, Yannis

AU - Pitkänen, Niina

AU - Snieder, Harold

AU - Heinrich, Joachim

AU - Timpson, Nicholas J

AU - Wang, Tao

AU - Yuji, Hinoda

AU - Zeggini, Eleftheria

AU - Dedoussis, George V

AU - Kaplan, Robert C

AU - Wylie-Rosett, Judith

AU - Loos, Ruth J F

AU - Hu, Frank B

AU - Qi, Lu

N1 - © 2015 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered.

PY - 2015/7

Y1 - 2015/7

N2 - The FTO gene harbors variation with the strongest effect on adiposity and obesity risk. Previous data support a role for FTO variation in influencing food intake. We conducted a combined analysis of 16,094 boys and girls aged 1–18 years from 14 studies to examine the following: 1) the association between the FTO rs9939609 variant (or a proxy) and total energy and macronutrient intake; and 2) the interaction between the FTO variant and dietary intake, and the effect on BMI. We found that the BMI-increasing allele (minor allele) of the FTO variant was associated with increased total energy intake (effect per allele = 14.3 kcal/day [95% CI 5.9, 22.7 kcal/day], P = 6.5 × 10−4), but not with protein, carbohydrate, or fat intake. We also found that protein intake modified the association between the FTO variant and BMI (interactive effect per allele = 0.08 SD [0.03, 0.12 SD], P for interaction = 7.2 × 10−4): the association between FTO genotype and BMI was much stronger in individuals with high protein intake (effect per allele = 0.10 SD [0.07, 0.13 SD], P = 8.2 × 10−10) than in those with low intake (effect per allele = 0.04 SD [0.01, 0.07 SD], P = 0.02). Our results suggest that the FTO variant that confers a predisposition to higher BMI is associated with higher total energy intake, and that lower dietary protein intake attenuates the association between FTO genotype and adiposity in children and adolescents.

AB - The FTO gene harbors variation with the strongest effect on adiposity and obesity risk. Previous data support a role for FTO variation in influencing food intake. We conducted a combined analysis of 16,094 boys and girls aged 1–18 years from 14 studies to examine the following: 1) the association between the FTO rs9939609 variant (or a proxy) and total energy and macronutrient intake; and 2) the interaction between the FTO variant and dietary intake, and the effect on BMI. We found that the BMI-increasing allele (minor allele) of the FTO variant was associated with increased total energy intake (effect per allele = 14.3 kcal/day [95% CI 5.9, 22.7 kcal/day], P = 6.5 × 10−4), but not with protein, carbohydrate, or fat intake. We also found that protein intake modified the association between the FTO variant and BMI (interactive effect per allele = 0.08 SD [0.03, 0.12 SD], P for interaction = 7.2 × 10−4): the association between FTO genotype and BMI was much stronger in individuals with high protein intake (effect per allele = 0.10 SD [0.07, 0.13 SD], P = 8.2 × 10−10) than in those with low intake (effect per allele = 0.04 SD [0.01, 0.07 SD], P = 0.02). Our results suggest that the FTO variant that confers a predisposition to higher BMI is associated with higher total energy intake, and that lower dietary protein intake attenuates the association between FTO genotype and adiposity in children and adolescents.

U2 - 10.2337/db14-1629

DO - 10.2337/db14-1629

M3 - Journal article

C2 - 25720386

VL - 64

SP - 2467

EP - 2476

JO - Diabetes

JF - Diabetes

SN - 0012-1797

IS - 7

ER -