TY - JOUR

T1 - Detection of triploidy at 11-14 weeks of gestation

T2 - a cohort study of 198,000 pregnant women

AU - Engelbrechtsen, Line

AU - Brøndum-Nielsen, Karen

AU - Ekelund, Charlotte

AU - Tabor, Ann

AU - Skibsted, Lillian

AU - the Danish Fetal Medicine study group

AU - Farlie, Richard

AU - Hoseth, Eva

AU - Larsen, Torben

AU - Petersen, Olav Bjørn

AU - Stornes, Inger

AU - Vejerslev, Lars O.

AU - Zingenberg, Helle

N1 - Copyright © 2013 ISUOG. Published by John Wiley & Sons, Ltd.

PY - 2013/11

Y1 - 2013/11

N2 - OBJECTIVES: To assess the detection rate of triploidy at first-trimester screening for trisomy 21 and evaluate outcome in triploid pregnancies. METHODS: From 2008-2011, 198,427 patients women with singleton pregnancies underwent first-trimester screening (FTS) at 11+2 - 14+0 weeks of gestation. FTS included: Nuchal translucency (NT), maternal serum free β-human chorionic gonadotrophin (β-hCG) and pregnancy associated plasma protein-A (PAPP-A). In all triploid fetuses FTS parameters were re-evaluated. Karyotypes were established by invasive testing (CVS or AC) or post abortem and obtained from the Danish Cytogenetic Central Register and the Danish Fetal Medicine Database. RESULTS: A total of 30 triploid fetuses attended FTS. Twenty-five triploid fetuses were diagnosed as a result of abnormal FTS, a detection rate of 83%.Twenty-three fetuses were identified due to a high risk of trisomy 13, 18 or 21 and two fetuses due to structural abnormalities at FTS. The incidence of triploidy at FTS was 1:6614. A smaller CRL than estimated by last menstrual period was found in 95 % of the fetuses with the data available for evaluation. Eight fetuses had larger BPD than expected by gestational age. 69, XXX fetuses had significantly lower β-hCG MoM and PAPP-A MoM than 69, XXY fetuses (p=0.045 and p=0.02). No infants with triploidy were born in the study period. Among the triploid gestations, 80% of the women chose termination of pregnancy, 16 % had spontaneous miscarriages, and one was stillborn. CONCLUSION: First trimester screening for trisomy 21 also provides a high detection rate for triploidy.

AB - OBJECTIVES: To assess the detection rate of triploidy at first-trimester screening for trisomy 21 and evaluate outcome in triploid pregnancies. METHODS: From 2008-2011, 198,427 patients women with singleton pregnancies underwent first-trimester screening (FTS) at 11+2 - 14+0 weeks of gestation. FTS included: Nuchal translucency (NT), maternal serum free β-human chorionic gonadotrophin (β-hCG) and pregnancy associated plasma protein-A (PAPP-A). In all triploid fetuses FTS parameters were re-evaluated. Karyotypes were established by invasive testing (CVS or AC) or post abortem and obtained from the Danish Cytogenetic Central Register and the Danish Fetal Medicine Database. RESULTS: A total of 30 triploid fetuses attended FTS. Twenty-five triploid fetuses were diagnosed as a result of abnormal FTS, a detection rate of 83%.Twenty-three fetuses were identified due to a high risk of trisomy 13, 18 or 21 and two fetuses due to structural abnormalities at FTS. The incidence of triploidy at FTS was 1:6614. A smaller CRL than estimated by last menstrual period was found in 95 % of the fetuses with the data available for evaluation. Eight fetuses had larger BPD than expected by gestational age. 69, XXX fetuses had significantly lower β-hCG MoM and PAPP-A MoM than 69, XXY fetuses (p=0.045 and p=0.02). No infants with triploidy were born in the study period. Among the triploid gestations, 80% of the women chose termination of pregnancy, 16 % had spontaneous miscarriages, and one was stillborn. CONCLUSION: First trimester screening for trisomy 21 also provides a high detection rate for triploidy.

U2 - 10.1002/uog.12460

DO - 10.1002/uog.12460

M3 - Journal article

C2 - 23494847

VL - 42

SP - 530

EP - 535

JO - Ultrasound in Obstetrics and Gynecology

JF - Ultrasound in Obstetrics and Gynecology

SN - 0960-7692

IS - 5

ER -