Deficient SOCS3 and SHP-1 Expression in Psoriatic T Cells

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Standard

Deficient SOCS3 and SHP-1 Expression in Psoriatic T Cells. / Eriksen, Karsten W; Woetmann, Anders; Skov, Lone; Krejsgaard, Thorbjørn; Bovin, Lone F; Hansen, Mikkel L; Grønbæk, Kirsten; Billestrup, Nils; Nissen, Mogens H; Geisler, Carsten; Wasik, Mariusz A; Odum, Niels.

I: Journal of Investigative Dermatology, Bind 130, Nr. 6, 2010, s. 1590-7.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Eriksen, KW, Woetmann, A, Skov, L, Krejsgaard, T, Bovin, LF, Hansen, ML, Grønbæk, K, Billestrup, N, Nissen, MH, Geisler, C, Wasik, MA & Odum, N 2010, 'Deficient SOCS3 and SHP-1 Expression in Psoriatic T Cells', Journal of Investigative Dermatology, bind 130, nr. 6, s. 1590-7. https://doi.org/10.1038/jid.2010.6

APA

Eriksen, K. W., Woetmann, A., Skov, L., Krejsgaard, T., Bovin, L. F., Hansen, M. L., Grønbæk, K., Billestrup, N., Nissen, M. H., Geisler, C., Wasik, M. A., & Odum, N. (2010). Deficient SOCS3 and SHP-1 Expression in Psoriatic T Cells. Journal of Investigative Dermatology, 130(6), 1590-7. https://doi.org/10.1038/jid.2010.6

Vancouver

Eriksen KW, Woetmann A, Skov L, Krejsgaard T, Bovin LF, Hansen ML o.a. Deficient SOCS3 and SHP-1 Expression in Psoriatic T Cells. Journal of Investigative Dermatology. 2010;130(6):1590-7. https://doi.org/10.1038/jid.2010.6

Author

Eriksen, Karsten W ; Woetmann, Anders ; Skov, Lone ; Krejsgaard, Thorbjørn ; Bovin, Lone F ; Hansen, Mikkel L ; Grønbæk, Kirsten ; Billestrup, Nils ; Nissen, Mogens H ; Geisler, Carsten ; Wasik, Mariusz A ; Odum, Niels. / Deficient SOCS3 and SHP-1 Expression in Psoriatic T Cells. I: Journal of Investigative Dermatology. 2010 ; Bind 130, Nr. 6. s. 1590-7.

Bibtex

@article{f1ca1ef01bb511df8ed1000ea68e967b,
title = "Deficient SOCS3 and SHP-1 Expression in Psoriatic T Cells",
abstract = "IFN-alpha and skin-infiltrating activated T lymphocytes have important roles in the pathogenesis of psoriasis. T cells from psoriatic patients display an increased sensitivity to IFN-alpha, but the pathological mechanisms behind the hyperresponsiveness to IFN-alpha remained unknown. In this study, we show that psoriatic T cells display deficient expression of the suppressor of cytokine signaling (SOCS)3 in response to IFN-alpha and a low baseline expression of the SH2-domain-containing protein-tyrosine phosphatase (SHP)-1 when compared with skin T cells from nonpsoriatic donors. Moreover, IFN-alpha-stimulated psoriatic T cells show enhanced activation of JAKs (JAK1 and TYK2) and signal transducers and activators of transcription. Increased expression of SOCS3 proteins resulting from proteasomal blockade partially inhibits IFN-alpha response. Similarly, forced expression of SOCS3 and SHP-1 inhibits IFN-alpha signaling in psoriatic T cells. In conclusion, our data suggest that loss of regulatory control is involved in the aberrant hypersensitivity of psoriatic T cells to IFN-alpha.Journal of Investigative Dermatology advance online publication, 4 February 2010; doi:10.1038/jid.2010.6.",
author = "Eriksen, {Karsten W} and Anders Woetmann and Lone Skov and Thorbj{\o}rn Krejsgaard and Bovin, {Lone F} and Hansen, {Mikkel L} and Kirsten Gr{\o}nb{\ae}k and Nils Billestrup and Nissen, {Mogens H} and Carsten Geisler and Wasik, {Mariusz A} and Niels Odum",
year = "2010",
doi = "10.1038/jid.2010.6",
language = "English",
volume = "130",
pages = "1590--7",
journal = "Journal of Investigative Dermatology",
issn = "0022-202X",
publisher = "nature publishing group",
number = "6",

}

RIS

TY - JOUR

T1 - Deficient SOCS3 and SHP-1 Expression in Psoriatic T Cells

AU - Eriksen, Karsten W

AU - Woetmann, Anders

AU - Skov, Lone

AU - Krejsgaard, Thorbjørn

AU - Bovin, Lone F

AU - Hansen, Mikkel L

AU - Grønbæk, Kirsten

AU - Billestrup, Nils

AU - Nissen, Mogens H

AU - Geisler, Carsten

AU - Wasik, Mariusz A

AU - Odum, Niels

PY - 2010

Y1 - 2010

N2 - IFN-alpha and skin-infiltrating activated T lymphocytes have important roles in the pathogenesis of psoriasis. T cells from psoriatic patients display an increased sensitivity to IFN-alpha, but the pathological mechanisms behind the hyperresponsiveness to IFN-alpha remained unknown. In this study, we show that psoriatic T cells display deficient expression of the suppressor of cytokine signaling (SOCS)3 in response to IFN-alpha and a low baseline expression of the SH2-domain-containing protein-tyrosine phosphatase (SHP)-1 when compared with skin T cells from nonpsoriatic donors. Moreover, IFN-alpha-stimulated psoriatic T cells show enhanced activation of JAKs (JAK1 and TYK2) and signal transducers and activators of transcription. Increased expression of SOCS3 proteins resulting from proteasomal blockade partially inhibits IFN-alpha response. Similarly, forced expression of SOCS3 and SHP-1 inhibits IFN-alpha signaling in psoriatic T cells. In conclusion, our data suggest that loss of regulatory control is involved in the aberrant hypersensitivity of psoriatic T cells to IFN-alpha.Journal of Investigative Dermatology advance online publication, 4 February 2010; doi:10.1038/jid.2010.6.

AB - IFN-alpha and skin-infiltrating activated T lymphocytes have important roles in the pathogenesis of psoriasis. T cells from psoriatic patients display an increased sensitivity to IFN-alpha, but the pathological mechanisms behind the hyperresponsiveness to IFN-alpha remained unknown. In this study, we show that psoriatic T cells display deficient expression of the suppressor of cytokine signaling (SOCS)3 in response to IFN-alpha and a low baseline expression of the SH2-domain-containing protein-tyrosine phosphatase (SHP)-1 when compared with skin T cells from nonpsoriatic donors. Moreover, IFN-alpha-stimulated psoriatic T cells show enhanced activation of JAKs (JAK1 and TYK2) and signal transducers and activators of transcription. Increased expression of SOCS3 proteins resulting from proteasomal blockade partially inhibits IFN-alpha response. Similarly, forced expression of SOCS3 and SHP-1 inhibits IFN-alpha signaling in psoriatic T cells. In conclusion, our data suggest that loss of regulatory control is involved in the aberrant hypersensitivity of psoriatic T cells to IFN-alpha.Journal of Investigative Dermatology advance online publication, 4 February 2010; doi:10.1038/jid.2010.6.

U2 - 10.1038/jid.2010.6

DO - 10.1038/jid.2010.6

M3 - Journal article

C2 - 20130595

VL - 130

SP - 1590

EP - 1597

JO - Journal of Investigative Dermatology

JF - Journal of Investigative Dermatology

SN - 0022-202X

IS - 6

ER -

ID: 18051087