Climate change is expected to influence urban living conditions and challenge the ability of cities to adapt to and mitigate climate change. Urban climates will be faced with elevated temperatures and future climate conditions are expected to cause higher ozone concentrations, increased biogenic emissions from vegetation, changes in the chemistry of the atmosphere and changes in deposition of particulate air pollution. This paper describes a conceptual outline of a decision-support system for assessment of the impacts of climate change on urban climate and air quality, and for assessment of integrated climate change and air pollution adaptation and mitigation strategies.