C-Terminally modified peptides via cleavage of the HMBA linker by O-, N- or S-nucleophiles

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Standard

C-Terminally modified peptides via cleavage of the HMBA linker by O-, N- or S-nucleophiles. / Hansen, Jonas; Diness, Frederik; Meldal, Morten Peter.

I: Organic & Biomolecular Chemistry, Bind 14, Nr. 12, 2016, s. 3238-3245.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Hansen, J, Diness, F & Meldal, MP 2016, 'C-Terminally modified peptides via cleavage of the HMBA linker by O-, N- or S-nucleophiles', Organic & Biomolecular Chemistry, bind 14, nr. 12, s. 3238-3245. https://doi.org/10.1039/c6ob00213g

APA

Hansen, J., Diness, F., & Meldal, M. P. (2016). C-Terminally modified peptides via cleavage of the HMBA linker by O-, N- or S-nucleophiles. Organic & Biomolecular Chemistry, 14(12), 3238-3245. https://doi.org/10.1039/c6ob00213g

Vancouver

Hansen J, Diness F, Meldal MP. C-Terminally modified peptides via cleavage of the HMBA linker by O-, N- or S-nucleophiles. Organic & Biomolecular Chemistry. 2016;14(12):3238-3245. https://doi.org/10.1039/c6ob00213g

Author

Hansen, Jonas ; Diness, Frederik ; Meldal, Morten Peter. / C-Terminally modified peptides via cleavage of the HMBA linker by O-, N- or S-nucleophiles. I: Organic & Biomolecular Chemistry. 2016 ; Bind 14, Nr. 12. s. 3238-3245.

Bibtex

@article{cb69adbfbcaf4eeaae668bfc29be533a,

title = "C-Terminally modified peptides via cleavage of the HMBA linker by O-, N- or S-nucleophiles",

abstract = "A large variety of C-terminally modified peptides was obtained by nucleophilic cleavage of the ester bond in solid phase linked peptide esters of 4-hydroxymethyl benzamide (HMBA). The developed methods provided peptides, C-terminally functionalized as esters, amides and thioesters, with high purity directly from the resin in a single reaction step. A comprehensive screening of the reaction conditions and scope for nucleophilic cleavage of peptides from the HMBA linker was performed.",

author = "Jonas Hansen and Frederik Diness and Meldal, {Morten Peter}",

year = "2016",

doi = "10.1039/c6ob00213g",

language = "English",

volume = "14",

pages = "3238--3245",

journal = "Organic & Biomolecular Chemistry",

issn = "1470-4358",

publisher = "Royal Society of Chemistry",

number = "12",

}

RIS

TY - JOUR

T1 - C-Terminally modified peptides via cleavage of the HMBA linker by O-, N- or S-nucleophiles

AU - Hansen, Jonas

AU - Diness, Frederik

AU - Meldal, Morten Peter

PY - 2016

Y1 - 2016

N2 - A large variety of C-terminally modified peptides was obtained by nucleophilic cleavage of the ester bond in solid phase linked peptide esters of 4-hydroxymethyl benzamide (HMBA). The developed methods provided peptides, C-terminally functionalized as esters, amides and thioesters, with high purity directly from the resin in a single reaction step. A comprehensive screening of the reaction conditions and scope for nucleophilic cleavage of peptides from the HMBA linker was performed.

AB - A large variety of C-terminally modified peptides was obtained by nucleophilic cleavage of the ester bond in solid phase linked peptide esters of 4-hydroxymethyl benzamide (HMBA). The developed methods provided peptides, C-terminally functionalized as esters, amides and thioesters, with high purity directly from the resin in a single reaction step. A comprehensive screening of the reaction conditions and scope for nucleophilic cleavage of peptides from the HMBA linker was performed.

U2 - 10.1039/c6ob00213g

DO - 10.1039/c6ob00213g

M3 - Journal article

C2 - 26924021

VL - 14

SP - 3238

EP - 3245

JO - Organic & Biomolecular Chemistry

JF - Organic & Biomolecular Chemistry

SN - 1470-4358

IS - 12

ER -

ID: 158554422