Standard
COVID-19 severity and mortality in patients with CLL : an update of the international ERIC and Campus CLL study. / Chatzikonstantinou, Thomas; Kapetanakis, Anargyros; Scarfò, Lydia; Karakatsoulis, Georgios; Allsup, David; Cabrero, Alejandro Alonso; Andres, Martin; Antic, Darko; Baile, Mónica; Baliakas, Panagiotis; Bron, Dominique; Capasso, Antonella; Chatzileontiadou, Sofia; Cordoba, Raul; Correa, Juan Gonzalo; Cuéllar-García, Carolina; De Paoli, Lorenzo; De Paolis, Maria Rosaria; Del Poeta, Giovanni; Demosthenous, Christos; Dimou, Maria; Donaldson, David; Doubek, Michael; Efstathopoulou, Maria; Eichhorst, Barbara; El-Ashwah, Shaimaa; Enrico, Alicia; Espinet, Blanca; Farina, Lucia; Ferrari, Angela; Foglietta, Myriam; Frederiksen, Henrik; Fürstenau, Moritz; García-Marco, José A.; García-Serra, Rocío; Gentile, Massimo; Gimeno, Eva; Glenthøj, Andreas; Gomes da Silva, Maria; Gutwein, Odit; Hakobyan, Yervand K.; Herishanu, Yair; Hernández-Rivas, José Ángel; Herold, Tobias; Innocenti, Idanna; Itchaki, Gilad; Jaksic, Ozren; Janssens, Ann; Kalashnikova, Оlga B.; Kalicińska, Elżbieta; Karlsson, Linda Katharina; Kater, Arnon P.; Kersting, Sabina; Labrador, Jorge; Lad, Deepesh; Laurenti, Luca; Levin, Mark David; Lista, Enrico; Lopez-Garcia, Alberto; Malerba, Lara; Marasca, Roberto; Marchetti, Monia; Marquet, Juan; Mattsson, Mattias; Mauro, Francesca R.; Milosevic, Ivana; Mirás, Fatima; Morawska, Marta; Motta, Marina; Munir, Talha; Murru, Roberta; Niemann, Carsten U.; Rodrigues, Raquel Nunes; Olivieri, Jacopo; Orsucci, Lorella; Papaioannou, Maria; Pavlovsky, Miguel Arturo; Piskunova, Inga; Popov, Viola Maria; Quaglia, Francesca Maria; Quaresmini, Giulia; Qvist, Kristian; Reda, Gianluigi; Rigolin, Gian Matteo; Ruchlemer, Rosa; Saghumyan, Gevorg; Shrestha, Amit; Šimkovič, Martin; Špaček, Martin; Sportoletti, Paolo; Stanca, Oana; Stavroyianni, Niki; Tadmor, Tamar; Te Raa, Doreen; Tonino, Sanne H.; Trentin, Livio; Van Der Spek, Ellen; van Gelder, Michel; van Kampen, Roel; Varettoni, Marzia; Visentin, Andrea; Vitale, Candida; Wasik-Szczepanek, Ewa; Wróbel, Tomasz; San Segundo, Lucrecia Yáñez; Yassin, Mohamed; Coscia, Marta; Rambaldi, Alessandro; Montserrat, Emili; Foà, Robin; Cuneo, Antonio; Stamatopoulos, Kostas; Ghia, Paolo.
I:
Leukemia, Bind 35, Nr. 12, 2021, s. 3444-3454.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
Chatzikonstantinou, T, Kapetanakis, A, Scarfò, L, Karakatsoulis, G, Allsup, D, Cabrero, AA, Andres, M, Antic, D, Baile, M, Baliakas, P, Bron, D, Capasso, A, Chatzileontiadou, S, Cordoba, R, Correa, JG, Cuéllar-García, C, De Paoli, L, De Paolis, MR, Del Poeta, G, Demosthenous, C, Dimou, M, Donaldson, D, Doubek, M, Efstathopoulou, M, Eichhorst, B, El-Ashwah, S, Enrico, A, Espinet, B, Farina, L, Ferrari, A, Foglietta, M, Frederiksen, H, Fürstenau, M, García-Marco, JA, García-Serra, R, Gentile, M, Gimeno, E
, Glenthøj, A, Gomes da Silva, M, Gutwein, O, Hakobyan, YK, Herishanu, Y, Hernández-Rivas, JÁ, Herold, T, Innocenti, I, Itchaki, G, Jaksic, O, Janssens, A, Kalashnikova, ОB, Kalicińska, E, Karlsson, LK, Kater, AP, Kersting, S, Labrador, J, Lad, D, Laurenti, L, Levin, MD, Lista, E, Lopez-Garcia, A, Malerba, L, Marasca, R, Marchetti, M, Marquet, J, Mattsson, M, Mauro, FR, Milosevic, I, Mirás, F, Morawska, M, Motta, M, Munir, T, Murru, R
, Niemann, CU, Rodrigues, RN, Olivieri, J, Orsucci, L, Papaioannou, M, Pavlovsky, MA, Piskunova, I, Popov, VM, Quaglia, FM, Quaresmini, G, Qvist, K, Reda, G, Rigolin, GM, Ruchlemer, R, Saghumyan, G, Shrestha, A, Šimkovič, M, Špaček, M, Sportoletti, P, Stanca, O, Stavroyianni, N, Tadmor, T, Te Raa, D, Tonino, SH, Trentin, L, Van Der Spek, E, van Gelder, M, van Kampen, R, Varettoni, M, Visentin, A, Vitale, C, Wasik-Szczepanek, E, Wróbel, T, San Segundo, LY, Yassin, M, Coscia, M, Rambaldi, A, Montserrat, E, Foà, R, Cuneo, A, Stamatopoulos, K & Ghia, P 2021, '
COVID-19 severity and mortality in patients with CLL: an update of the international ERIC and Campus CLL study',
Leukemia, bind 35, nr. 12, s. 3444-3454.
https://doi.org/10.1038/s41375-021-01450-8
APA
Chatzikonstantinou, T., Kapetanakis, A., Scarfò, L., Karakatsoulis, G., Allsup, D., Cabrero, A. A., Andres, M., Antic, D., Baile, M., Baliakas, P., Bron, D., Capasso, A., Chatzileontiadou, S., Cordoba, R., Correa, J. G., Cuéllar-García, C., De Paoli, L., De Paolis, M. R., Del Poeta, G., ... Ghia, P. (2021).
COVID-19 severity and mortality in patients with CLL: an update of the international ERIC and Campus CLL study.
Leukemia,
35(12), 3444-3454.
https://doi.org/10.1038/s41375-021-01450-8
Vancouver
Chatzikonstantinou T, Kapetanakis A, Scarfò L, Karakatsoulis G, Allsup D, Cabrero AA o.a.
COVID-19 severity and mortality in patients with CLL: an update of the international ERIC and Campus CLL study.
Leukemia. 2021;35(12):3444-3454.
https://doi.org/10.1038/s41375-021-01450-8
Author
Chatzikonstantinou, Thomas ; Kapetanakis, Anargyros ; Scarfò, Lydia ; Karakatsoulis, Georgios ; Allsup, David ; Cabrero, Alejandro Alonso ; Andres, Martin ; Antic, Darko ; Baile, Mónica ; Baliakas, Panagiotis ; Bron, Dominique ; Capasso, Antonella ; Chatzileontiadou, Sofia ; Cordoba, Raul ; Correa, Juan Gonzalo ; Cuéllar-García, Carolina ; De Paoli, Lorenzo ; De Paolis, Maria Rosaria ; Del Poeta, Giovanni ; Demosthenous, Christos ; Dimou, Maria ; Donaldson, David ; Doubek, Michael ; Efstathopoulou, Maria ; Eichhorst, Barbara ; El-Ashwah, Shaimaa ; Enrico, Alicia ; Espinet, Blanca ; Farina, Lucia ; Ferrari, Angela ; Foglietta, Myriam ; Frederiksen, Henrik ; Fürstenau, Moritz ; García-Marco, José A. ; García-Serra, Rocío ; Gentile, Massimo ; Gimeno, Eva ; Glenthøj, Andreas ; Gomes da Silva, Maria ; Gutwein, Odit ; Hakobyan, Yervand K. ; Herishanu, Yair ; Hernández-Rivas, José Ángel ; Herold, Tobias ; Innocenti, Idanna ; Itchaki, Gilad ; Jaksic, Ozren ; Janssens, Ann ; Kalashnikova, Оlga B. ; Kalicińska, Elżbieta ; Karlsson, Linda Katharina ; Kater, Arnon P. ; Kersting, Sabina ; Labrador, Jorge ; Lad, Deepesh ; Laurenti, Luca ; Levin, Mark David ; Lista, Enrico ; Lopez-Garcia, Alberto ; Malerba, Lara ; Marasca, Roberto ; Marchetti, Monia ; Marquet, Juan ; Mattsson, Mattias ; Mauro, Francesca R. ; Milosevic, Ivana ; Mirás, Fatima ; Morawska, Marta ; Motta, Marina ; Munir, Talha ; Murru, Roberta ; Niemann, Carsten U. ; Rodrigues, Raquel Nunes ; Olivieri, Jacopo ; Orsucci, Lorella ; Papaioannou, Maria ; Pavlovsky, Miguel Arturo ; Piskunova, Inga ; Popov, Viola Maria ; Quaglia, Francesca Maria ; Quaresmini, Giulia ; Qvist, Kristian ; Reda, Gianluigi ; Rigolin, Gian Matteo ; Ruchlemer, Rosa ; Saghumyan, Gevorg ; Shrestha, Amit ; Šimkovič, Martin ; Špaček, Martin ; Sportoletti, Paolo ; Stanca, Oana ; Stavroyianni, Niki ; Tadmor, Tamar ; Te Raa, Doreen ; Tonino, Sanne H. ; Trentin, Livio ; Van Der Spek, Ellen ; van Gelder, Michel ; van Kampen, Roel ; Varettoni, Marzia ; Visentin, Andrea ; Vitale, Candida ; Wasik-Szczepanek, Ewa ; Wróbel, Tomasz ; San Segundo, Lucrecia Yáñez ; Yassin, Mohamed ; Coscia, Marta ; Rambaldi, Alessandro ; Montserrat, Emili ; Foà, Robin ; Cuneo, Antonio ; Stamatopoulos, Kostas ; Ghia, Paolo. / COVID-19 severity and mortality in patients with CLL : an update of the international ERIC and Campus CLL study. I: Leukemia. 2021 ; Bind 35, Nr. 12. s. 3444-3454.
Bibtex
@article{b465123ca3e74765a43de8e9f6dfd222,
title = "COVID-19 severity and mortality in patients with CLL: an update of the international ERIC and Campus CLL study",
abstract = "Patients with chronic lymphocytic leukemia (CLL) may be more susceptible to Coronavirus disease 2019 (COVID-19) due to age, disease, and treatment-related immunosuppression. We aimed to assess risk factors of outcome and elucidate the impact of CLL-directed treatments on the course of COVID-19. We conducted a retrospective, international study, collectively including 941 patients with CLL and confirmed COVID-19. Data from the beginning of the pandemic until March 16, 2021, were collected from 91 centers. The risk factors of case fatality rate (CFR), disease severity, and overall survival (OS) were investigated. OS analysis was restricted to patients with severe COVID-19 (definition: hospitalization with need of oxygen or admission into an intensive care unit). CFR in patients with severe COVID-19 was 38.4%. OS was inferior for patients in all treatment categories compared to untreated (p < 0.001). Untreated patients had a lower risk of death (HR = 0.54, 95% CI:0.41–0.72). The risk of death was higher for older patients and those suffering from cardiac failure (HR = 1.03, 95% CI:1.02–1.04; HR = 1.79, 95% CI:1.04–3.07, respectively). Age, CLL-directed treatment, and cardiac failure were significant risk factors of OS. Untreated patients had a better chance of survival than those on treatment or recently treated.",
author = "Thomas Chatzikonstantinou and Anargyros Kapetanakis and Lydia Scarf{\`o} and Georgios Karakatsoulis and David Allsup and Cabrero, {Alejandro Alonso} and Martin Andres and Darko Antic and M{\'o}nica Baile and Panagiotis Baliakas and Dominique Bron and Antonella Capasso and Sofia Chatzileontiadou and Raul Cordoba and Correa, {Juan Gonzalo} and Carolina Cu{\'e}llar-Garc{\'i}a and {De Paoli}, Lorenzo and {De Paolis}, {Maria Rosaria} and {Del Poeta}, Giovanni and Christos Demosthenous and Maria Dimou and David Donaldson and Michael Doubek and Maria Efstathopoulou and Barbara Eichhorst and Shaimaa El-Ashwah and Alicia Enrico and Blanca Espinet and Lucia Farina and Angela Ferrari and Myriam Foglietta and Henrik Frederiksen and Moritz F{\"u}rstenau and Garc{\'i}a-Marco, {Jos{\'e} A.} and Roc{\'i}o Garc{\'i}a-Serra and Massimo Gentile and Eva Gimeno and Andreas Glenth{\o}j and {Gomes da Silva}, Maria and Odit Gutwein and Hakobyan, {Yervand K.} and Yair Herishanu and Hern{\'a}ndez-Rivas, {Jos{\'e} {\'A}ngel} and Tobias Herold and Idanna Innocenti and Gilad Itchaki and Ozren Jaksic and Ann Janssens and Kalashnikova, {Оlga B.} and El{\.z}bieta Kalici{\'n}ska and Karlsson, {Linda Katharina} and Kater, {Arnon P.} and Sabina Kersting and Jorge Labrador and Deepesh Lad and Luca Laurenti and Levin, {Mark David} and Enrico Lista and Alberto Lopez-Garcia and Lara Malerba and Roberto Marasca and Monia Marchetti and Juan Marquet and Mattias Mattsson and Mauro, {Francesca R.} and Ivana Milosevic and Fatima Mir{\'a}s and Marta Morawska and Marina Motta and Talha Munir and Roberta Murru and Niemann, {Carsten U.} and Rodrigues, {Raquel Nunes} and Jacopo Olivieri and Lorella Orsucci and Maria Papaioannou and Pavlovsky, {Miguel Arturo} and Inga Piskunova and Popov, {Viola Maria} and Quaglia, {Francesca Maria} and Giulia Quaresmini and Kristian Qvist and Gianluigi Reda and Rigolin, {Gian Matteo} and Rosa Ruchlemer and Gevorg Saghumyan and Amit Shrestha and Martin {\v S}imkovi{\v c} and Martin {\v S}pa{\v c}ek and Paolo Sportoletti and Oana Stanca and Niki Stavroyianni and Tamar Tadmor and {Te Raa}, Doreen and Tonino, {Sanne H.} and Livio Trentin and {Van Der Spek}, Ellen and {van Gelder}, Michel and {van Kampen}, Roel and Marzia Varettoni and Andrea Visentin and Candida Vitale and Ewa Wasik-Szczepanek and Tomasz Wr{\'o}bel and {San Segundo}, {Lucrecia Y{\'a}{\~n}ez} and Mohamed Yassin and Marta Coscia and Alessandro Rambaldi and Emili Montserrat and Robin Fo{\`a} and Antonio Cuneo and Kostas Stamatopoulos and Paolo Ghia",
note = "Publisher Copyright: {\textcopyright} 2021, The Author(s).",
year = "2021",
doi = "10.1038/s41375-021-01450-8",
language = "English",
volume = "35",
pages = "3444--3454",
journal = "Leukemia",
issn = "0887-6924",
publisher = "nature publishing group",
number = "12",
}
RIS
TY - JOUR
T1 - COVID-19 severity and mortality in patients with CLL
T2 - an update of the international ERIC and Campus CLL study
AU - Chatzikonstantinou, Thomas
AU - Kapetanakis, Anargyros
AU - Scarfò, Lydia
AU - Karakatsoulis, Georgios
AU - Allsup, David
AU - Cabrero, Alejandro Alonso
AU - Andres, Martin
AU - Antic, Darko
AU - Baile, Mónica
AU - Baliakas, Panagiotis
AU - Bron, Dominique
AU - Capasso, Antonella
AU - Chatzileontiadou, Sofia
AU - Cordoba, Raul
AU - Correa, Juan Gonzalo
AU - Cuéllar-García, Carolina
AU - De Paoli, Lorenzo
AU - De Paolis, Maria Rosaria
AU - Del Poeta, Giovanni
AU - Demosthenous, Christos
AU - Dimou, Maria
AU - Donaldson, David
AU - Doubek, Michael
AU - Efstathopoulou, Maria
AU - Eichhorst, Barbara
AU - El-Ashwah, Shaimaa
AU - Enrico, Alicia
AU - Espinet, Blanca
AU - Farina, Lucia
AU - Ferrari, Angela
AU - Foglietta, Myriam
AU - Frederiksen, Henrik
AU - Fürstenau, Moritz
AU - García-Marco, José A.
AU - García-Serra, Rocío
AU - Gentile, Massimo
AU - Gimeno, Eva
AU - Glenthøj, Andreas
AU - Gomes da Silva, Maria
AU - Gutwein, Odit
AU - Hakobyan, Yervand K.
AU - Herishanu, Yair
AU - Hernández-Rivas, José Ángel
AU - Herold, Tobias
AU - Innocenti, Idanna
AU - Itchaki, Gilad
AU - Jaksic, Ozren
AU - Janssens, Ann
AU - Kalashnikova, Оlga B.
AU - Kalicińska, Elżbieta
AU - Karlsson, Linda Katharina
AU - Kater, Arnon P.
AU - Kersting, Sabina
AU - Labrador, Jorge
AU - Lad, Deepesh
AU - Laurenti, Luca
AU - Levin, Mark David
AU - Lista, Enrico
AU - Lopez-Garcia, Alberto
AU - Malerba, Lara
AU - Marasca, Roberto
AU - Marchetti, Monia
AU - Marquet, Juan
AU - Mattsson, Mattias
AU - Mauro, Francesca R.
AU - Milosevic, Ivana
AU - Mirás, Fatima
AU - Morawska, Marta
AU - Motta, Marina
AU - Munir, Talha
AU - Murru, Roberta
AU - Niemann, Carsten U.
AU - Rodrigues, Raquel Nunes
AU - Olivieri, Jacopo
AU - Orsucci, Lorella
AU - Papaioannou, Maria
AU - Pavlovsky, Miguel Arturo
AU - Piskunova, Inga
AU - Popov, Viola Maria
AU - Quaglia, Francesca Maria
AU - Quaresmini, Giulia
AU - Qvist, Kristian
AU - Reda, Gianluigi
AU - Rigolin, Gian Matteo
AU - Ruchlemer, Rosa
AU - Saghumyan, Gevorg
AU - Shrestha, Amit
AU - Šimkovič, Martin
AU - Špaček, Martin
AU - Sportoletti, Paolo
AU - Stanca, Oana
AU - Stavroyianni, Niki
AU - Tadmor, Tamar
AU - Te Raa, Doreen
AU - Tonino, Sanne H.
AU - Trentin, Livio
AU - Van Der Spek, Ellen
AU - van Gelder, Michel
AU - van Kampen, Roel
AU - Varettoni, Marzia
AU - Visentin, Andrea
AU - Vitale, Candida
AU - Wasik-Szczepanek, Ewa
AU - Wróbel, Tomasz
AU - San Segundo, Lucrecia Yáñez
AU - Yassin, Mohamed
AU - Coscia, Marta
AU - Rambaldi, Alessandro
AU - Montserrat, Emili
AU - Foà, Robin
AU - Cuneo, Antonio
AU - Stamatopoulos, Kostas
AU - Ghia, Paolo
N1 - Publisher Copyright:
© 2021, The Author(s).
PY - 2021
Y1 - 2021
N2 - Patients with chronic lymphocytic leukemia (CLL) may be more susceptible to Coronavirus disease 2019 (COVID-19) due to age, disease, and treatment-related immunosuppression. We aimed to assess risk factors of outcome and elucidate the impact of CLL-directed treatments on the course of COVID-19. We conducted a retrospective, international study, collectively including 941 patients with CLL and confirmed COVID-19. Data from the beginning of the pandemic until March 16, 2021, were collected from 91 centers. The risk factors of case fatality rate (CFR), disease severity, and overall survival (OS) were investigated. OS analysis was restricted to patients with severe COVID-19 (definition: hospitalization with need of oxygen or admission into an intensive care unit). CFR in patients with severe COVID-19 was 38.4%. OS was inferior for patients in all treatment categories compared to untreated (p < 0.001). Untreated patients had a lower risk of death (HR = 0.54, 95% CI:0.41–0.72). The risk of death was higher for older patients and those suffering from cardiac failure (HR = 1.03, 95% CI:1.02–1.04; HR = 1.79, 95% CI:1.04–3.07, respectively). Age, CLL-directed treatment, and cardiac failure were significant risk factors of OS. Untreated patients had a better chance of survival than those on treatment or recently treated.
AB - Patients with chronic lymphocytic leukemia (CLL) may be more susceptible to Coronavirus disease 2019 (COVID-19) due to age, disease, and treatment-related immunosuppression. We aimed to assess risk factors of outcome and elucidate the impact of CLL-directed treatments on the course of COVID-19. We conducted a retrospective, international study, collectively including 941 patients with CLL and confirmed COVID-19. Data from the beginning of the pandemic until March 16, 2021, were collected from 91 centers. The risk factors of case fatality rate (CFR), disease severity, and overall survival (OS) were investigated. OS analysis was restricted to patients with severe COVID-19 (definition: hospitalization with need of oxygen or admission into an intensive care unit). CFR in patients with severe COVID-19 was 38.4%. OS was inferior for patients in all treatment categories compared to untreated (p < 0.001). Untreated patients had a lower risk of death (HR = 0.54, 95% CI:0.41–0.72). The risk of death was higher for older patients and those suffering from cardiac failure (HR = 1.03, 95% CI:1.02–1.04; HR = 1.79, 95% CI:1.04–3.07, respectively). Age, CLL-directed treatment, and cardiac failure were significant risk factors of OS. Untreated patients had a better chance of survival than those on treatment or recently treated.
U2 - 10.1038/s41375-021-01450-8
DO - 10.1038/s41375-021-01450-8
M3 - Journal article
C2 - 34725454
AN - SCOPUS:85118404639
VL - 35
SP - 3444
EP - 3454
JO - Leukemia
JF - Leukemia
SN - 0887-6924
IS - 12
ER -