Coronary Artery Calcium Score Predicts Major Adverse Cardiovascular Events in Stable Chest Pain

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Standard

Coronary Artery Calcium Score Predicts Major Adverse Cardiovascular Events in Stable Chest Pain. / Biavati, Federico; Saba, Luca; Boussoussou, Melinda; Kofoed, Klaus F.; Benedek, Theodora; Donnelly, Patrick; Rodríguez-Palomares, José; Erglis, Andrejs; Štěchovský, Cyril; Šakalytė, Gintarė; Ađić, Nada Čemerlić; Gutberlet, Matthias; Dodd, Jonathan D.; Diez, Ignacio; Davis, Gershan; Zimmermann, Elke; Kępka, Cezary; Vidakovic, Radosav; Francone, Marco; Ilnicka-Suckiel, Małgorzata; Plank, Fabian; Knuuti, Juhani; Faria, Rita; Schröder, Stephen; Berry, Colin; Ruzsics, Balazs; Rieckmann, Nina; Kubiak, Christine; Hansen, Kristian Schultz; Müller-Nordhorn, Jacqueline; Maurovich-Horvat, Pál; Sigvardsen, Per E.; Benedek, Imre; Orr, Clare; Valente, Filipa Xavier; Zvaigzne, Ligita; Suchánek, Vojtěch; Jankauskas, Antanas; Ađić, Filip; Woinke, Michael; Cadogan, Diarmaid; Lecumberri, Iñigo; Thwaite, Erica; Kruk, Mariusz; Neskovic, Aleksandar N.; Mancone, Massimo; Kuśmierz, Donata; Feuchtner, Gudrun; Pietilä, Mikko; Ribeiro, Vasco Gama; Drosch, Tanja; Delles, Christian; Cau, Riccardo; Fisher, Michael; Merkely, Bela; Kragelund, Charlotte; Aurelian, Rosca; Kelly, Stephanie; del Blanco, Bruno García; Rubio, Ainhoa; Szilveszter, Bálint; Hove, Jens D.; Rodean, Ioana; Regan, Susan; Calabria, Hug Cuéllar; Édes, István Ferenc; Larsen, Linnea; Hodas, Roxana; Napp, Adriane E.; Haase, Robert; Feger, Sarah; Mohamed, Mahmoud; Serna-Higuita, Lina M.; Neumann, Konrad; Dreger, Henryk; Rief, Matthias; Wieske, Viktoria; Budoff, Matthew J.; Estrella, Melanie; Martus, Peter; Bosserdt, Maria; Dewey, Marc.

I: Radiology, Bind 310, Nr. 3, e231557, 2024.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Biavati, F, Saba, L, Boussoussou, M, Kofoed, KF, Benedek, T, Donnelly, P, Rodríguez-Palomares, J, Erglis, A, Štěchovský, C, Šakalytė, G, Ađić, NČ, Gutberlet, M, Dodd, JD, Diez, I, Davis, G, Zimmermann, E, Kępka, C, Vidakovic, R, Francone, M, Ilnicka-Suckiel, M, Plank, F, Knuuti, J, Faria, R, Schröder, S, Berry, C, Ruzsics, B, Rieckmann, N, Kubiak, C, Hansen, KS, Müller-Nordhorn, J, Maurovich-Horvat, P, Sigvardsen, PE, Benedek, I, Orr, C, Valente, FX, Zvaigzne, L, Suchánek, V, Jankauskas, A, Ađić, F, Woinke, M, Cadogan, D, Lecumberri, I, Thwaite, E, Kruk, M, Neskovic, AN, Mancone, M, Kuśmierz, D, Feuchtner, G, Pietilä, M, Ribeiro, VG, Drosch, T, Delles, C, Cau, R, Fisher, M, Merkely, B, Kragelund, C, Aurelian, R, Kelly, S, del Blanco, BG, Rubio, A, Szilveszter, B, Hove, JD, Rodean, I, Regan, S, Calabria, HC, Édes, IF, Larsen, L, Hodas, R, Napp, AE, Haase, R, Feger, S, Mohamed, M, Serna-Higuita, LM, Neumann, K, Dreger, H, Rief, M, Wieske, V, Budoff, MJ, Estrella, M, Martus, P, Bosserdt, M & Dewey, M 2024, 'Coronary Artery Calcium Score Predicts Major Adverse Cardiovascular Events in Stable Chest Pain', Radiology, bind 310, nr. 3, e231557. https://doi.org/10.1148/radiol.231557

APA

Biavati, F., Saba, L., Boussoussou, M., Kofoed, K. F., Benedek, T., Donnelly, P., Rodríguez-Palomares, J., Erglis, A., Štěchovský, C., Šakalytė, G., Ađić, N. Č., Gutberlet, M., Dodd, J. D., Diez, I., Davis, G., Zimmermann, E., Kępka, C., Vidakovic, R., Francone, M., ... Dewey, M. (2024). Coronary Artery Calcium Score Predicts Major Adverse Cardiovascular Events in Stable Chest Pain. Radiology, 310(3), [e231557]. https://doi.org/10.1148/radiol.231557

Vancouver

Biavati F, Saba L, Boussoussou M, Kofoed KF, Benedek T, Donnelly P o.a. Coronary Artery Calcium Score Predicts Major Adverse Cardiovascular Events in Stable Chest Pain. Radiology. 2024;310(3). e231557. https://doi.org/10.1148/radiol.231557

Author

Biavati, Federico ; Saba, Luca ; Boussoussou, Melinda ; Kofoed, Klaus F. ; Benedek, Theodora ; Donnelly, Patrick ; Rodríguez-Palomares, José ; Erglis, Andrejs ; Štěchovský, Cyril ; Šakalytė, Gintarė ; Ađić, Nada Čemerlić ; Gutberlet, Matthias ; Dodd, Jonathan D. ; Diez, Ignacio ; Davis, Gershan ; Zimmermann, Elke ; Kępka, Cezary ; Vidakovic, Radosav ; Francone, Marco ; Ilnicka-Suckiel, Małgorzata ; Plank, Fabian ; Knuuti, Juhani ; Faria, Rita ; Schröder, Stephen ; Berry, Colin ; Ruzsics, Balazs ; Rieckmann, Nina ; Kubiak, Christine ; Hansen, Kristian Schultz ; Müller-Nordhorn, Jacqueline ; Maurovich-Horvat, Pál ; Sigvardsen, Per E. ; Benedek, Imre ; Orr, Clare ; Valente, Filipa Xavier ; Zvaigzne, Ligita ; Suchánek, Vojtěch ; Jankauskas, Antanas ; Ađić, Filip ; Woinke, Michael ; Cadogan, Diarmaid ; Lecumberri, Iñigo ; Thwaite, Erica ; Kruk, Mariusz ; Neskovic, Aleksandar N. ; Mancone, Massimo ; Kuśmierz, Donata ; Feuchtner, Gudrun ; Pietilä, Mikko ; Ribeiro, Vasco Gama ; Drosch, Tanja ; Delles, Christian ; Cau, Riccardo ; Fisher, Michael ; Merkely, Bela ; Kragelund, Charlotte ; Aurelian, Rosca ; Kelly, Stephanie ; del Blanco, Bruno García ; Rubio, Ainhoa ; Szilveszter, Bálint ; Hove, Jens D. ; Rodean, Ioana ; Regan, Susan ; Calabria, Hug Cuéllar ; Édes, István Ferenc ; Larsen, Linnea ; Hodas, Roxana ; Napp, Adriane E. ; Haase, Robert ; Feger, Sarah ; Mohamed, Mahmoud ; Serna-Higuita, Lina M. ; Neumann, Konrad ; Dreger, Henryk ; Rief, Matthias ; Wieske, Viktoria ; Budoff, Matthew J. ; Estrella, Melanie ; Martus, Peter ; Bosserdt, Maria ; Dewey, Marc. / Coronary Artery Calcium Score Predicts Major Adverse Cardiovascular Events in Stable Chest Pain. I: Radiology. 2024 ; Bind 310, Nr. 3.

Bibtex

@article{a22ae36d48694831907be53635bcc079,

title = "Coronary Artery Calcium Score Predicts Major Adverse Cardiovascular Events in Stable Chest Pain",

abstract = "Background: Coronary artery calcium (CAC) has prognostic value for major adverse cardiovascular events (MACE) in asymptomatic individuals, whereas its role in symptomatic patients is less clear. Purpose: To assess the prognostic value of CAC scoring for MACE in participants with stable chest pain initially referred for invasive coronary angiography (ICA). Materials and Methods: This prespecified subgroup analysis from the Diagnostic Imaging Strategies for Patients With Stable Chest Pain and Intermediate Risk of Coronary Artery Disease (DISCHARGE) trial, conducted between October 2015 and April 2019 across 26 centers in 16 countries, focused on adult patients with stable chest pain referred for ICA. Participants were randomly assigned to undergo either ICA or coronary CT. CAC scores from noncontrast CT scans were categorized into low, intermediate, and high groups based on scores of 0, 1-399, and 400 or higher, respectively. The end point of the study was the occurrence of MACE (myocardial infarction, stroke, and cardiovascular death) over a median 3.5-year follow-up, analyzed using Cox proportional hazard regression tests. Results: The study involved 1749 participants (mean age, 60 years ± 10 [SD]; 992 female). The prevalence of obstructive coronary artery disease (CAD) at CT angiography rose from 4.1% (95% CI: 2.8, 5.8) in the CAC score 0 group to 76.1% (95% CI: 70.3, 81.2) in the CAC score 400 or higher group. Revascularization rates increased from 1.7% to 46.2% across the same groups (P < .001). The CAC score 0 group had a lower MACE risk (0.5%; HR, 0.08 [95% CI: 0.02, 0.30]; P < .001), as did the 1-399 CAC score group (1.9%; HR, 0.27 [95% CI: 0.13, 0.59]; P = .001), compared with the 400 or higher CAC score group (6.8%). No significant difference in MACE between sexes was observed (P = .68). Conclusion: In participants with stable chest pain initially referred for ICA, a CAC score of 0 showed very low risk of MACE, and higher CAC scores showed increasing risk of obstructive CAD, revascularization, and MACE at follow-up.",

author = "Federico Biavati and Luca Saba and Melinda Boussoussou and Kofoed, {Klaus F.} and Theodora Benedek and Patrick Donnelly and Jos{\'e} Rodr{\'i}guez-Palomares and Andrejs Erglis and Cyril {\v S}t{\v e}chovsk{\'y} and Gintarė {\v S}akalytė and A{\d}i{\'c}, {Nada {\v C}emerli{\'c}} and Matthias Gutberlet and Dodd, {Jonathan D.} and Ignacio Diez and Gershan Davis and Elke Zimmermann and Cezary K{\c e}pka and Radosav Vidakovic and Marco Francone and Ma{\l}gorzata Ilnicka-Suckiel and Fabian Plank and Juhani Knuuti and Rita Faria and Stephen Schr{\"o}der and Colin Berry and Balazs Ruzsics and Nina Rieckmann and Christine Kubiak and Hansen, {Kristian Schultz} and Jacqueline M{\"u}ller-Nordhorn and P{\'a}l Maurovich-Horvat and Sigvardsen, {Per E.} and Imre Benedek and Clare Orr and Valente, {Filipa Xavier} and Ligita Zvaigzne and Vojt{\v e}ch Such{\'a}nek and Antanas Jankauskas and Filip A{\d}i{\'c} and Michael Woinke and Diarmaid Cadogan and I{\~n}igo Lecumberri and Erica Thwaite and Mariusz Kruk and Neskovic, {Aleksandar N.} and Massimo Mancone and Donata Ku{\'s}mierz and Gudrun Feuchtner and Mikko Pietil{\"a} and Ribeiro, {Vasco Gama} and Tanja Drosch and Christian Delles and Riccardo Cau and Michael Fisher and Bela Merkely and Charlotte Kragelund and Rosca Aurelian and Stephanie Kelly and {del Blanco}, {Bruno Garc{\'i}a} and Ainhoa Rubio and B{\'a}lint Szilveszter and Hove, {Jens D.} and Ioana Rodean and Susan Regan and Calabria, {Hug Cu{\'e}llar} and {\'E}des, {Istv{\'a}n Ferenc} and Linnea Larsen and Roxana Hodas and Napp, {Adriane E.} and Robert Haase and Sarah Feger and Mahmoud Mohamed and Serna-Higuita, {Lina M.} and Konrad Neumann and Henryk Dreger and Matthias Rief and Viktoria Wieske and Budoff, {Matthew J.} and Melanie Estrella and Peter Martus and Maria Bosserdt and Marc Dewey",

note = "Publisher Copyright: {\textcopyright} RSNA, 2024.",

year = "2024",

doi = "10.1148/radiol.231557",

language = "English",

volume = "310",

journal = "Radiology",

issn = "0033-8419",

publisher = "Radiological Society of North America, Inc.",

number = "3",

}

RIS

TY - JOUR

T1 - Coronary Artery Calcium Score Predicts Major Adverse Cardiovascular Events in Stable Chest Pain

AU - Biavati, Federico

AU - Saba, Luca

AU - Boussoussou, Melinda

AU - Kofoed, Klaus F.

AU - Benedek, Theodora

AU - Donnelly, Patrick

AU - Rodríguez-Palomares, José

AU - Erglis, Andrejs

AU - Štěchovský, Cyril

AU - Šakalytė, Gintarė

AU - Ađić, Nada Čemerlić

AU - Gutberlet, Matthias

AU - Dodd, Jonathan D.

AU - Diez, Ignacio

AU - Davis, Gershan

AU - Zimmermann, Elke

AU - Kępka, Cezary

AU - Vidakovic, Radosav

AU - Francone, Marco

AU - Ilnicka-Suckiel, Małgorzata

AU - Plank, Fabian

AU - Knuuti, Juhani

AU - Faria, Rita

AU - Schröder, Stephen

AU - Berry, Colin

AU - Ruzsics, Balazs

AU - Rieckmann, Nina

AU - Kubiak, Christine

AU - Hansen, Kristian Schultz

AU - Müller-Nordhorn, Jacqueline

AU - Maurovich-Horvat, Pál

AU - Sigvardsen, Per E.

AU - Benedek, Imre

AU - Orr, Clare

AU - Valente, Filipa Xavier

AU - Zvaigzne, Ligita

AU - Suchánek, Vojtěch

AU - Jankauskas, Antanas

AU - Ađić, Filip

AU - Woinke, Michael

AU - Cadogan, Diarmaid

AU - Lecumberri, Iñigo

AU - Thwaite, Erica

AU - Kruk, Mariusz

AU - Neskovic, Aleksandar N.

AU - Mancone, Massimo

AU - Kuśmierz, Donata

AU - Feuchtner, Gudrun

AU - Pietilä, Mikko

AU - Ribeiro, Vasco Gama

AU - Drosch, Tanja

AU - Delles, Christian

AU - Cau, Riccardo

AU - Fisher, Michael

AU - Merkely, Bela

AU - Kragelund, Charlotte

AU - Aurelian, Rosca

AU - Kelly, Stephanie

AU - del Blanco, Bruno García

AU - Rubio, Ainhoa

AU - Szilveszter, Bálint

AU - Hove, Jens D.

AU - Rodean, Ioana

AU - Regan, Susan

AU - Calabria, Hug Cuéllar

AU - Édes, István Ferenc

AU - Larsen, Linnea

AU - Hodas, Roxana

AU - Napp, Adriane E.

AU - Haase, Robert

AU - Feger, Sarah

AU - Mohamed, Mahmoud

AU - Serna-Higuita, Lina M.

AU - Neumann, Konrad

AU - Dreger, Henryk

AU - Rief, Matthias

AU - Wieske, Viktoria

AU - Budoff, Matthew J.

AU - Estrella, Melanie

AU - Martus, Peter

AU - Bosserdt, Maria

AU - Dewey, Marc

PY - 2024

Y1 - 2024

N2 - Background: Coronary artery calcium (CAC) has prognostic value for major adverse cardiovascular events (MACE) in asymptomatic individuals, whereas its role in symptomatic patients is less clear. Purpose: To assess the prognostic value of CAC scoring for MACE in participants with stable chest pain initially referred for invasive coronary angiography (ICA). Materials and Methods: This prespecified subgroup analysis from the Diagnostic Imaging Strategies for Patients With Stable Chest Pain and Intermediate Risk of Coronary Artery Disease (DISCHARGE) trial, conducted between October 2015 and April 2019 across 26 centers in 16 countries, focused on adult patients with stable chest pain referred for ICA. Participants were randomly assigned to undergo either ICA or coronary CT. CAC scores from noncontrast CT scans were categorized into low, intermediate, and high groups based on scores of 0, 1-399, and 400 or higher, respectively. The end point of the study was the occurrence of MACE (myocardial infarction, stroke, and cardiovascular death) over a median 3.5-year follow-up, analyzed using Cox proportional hazard regression tests. Results: The study involved 1749 participants (mean age, 60 years ± 10 [SD]; 992 female). The prevalence of obstructive coronary artery disease (CAD) at CT angiography rose from 4.1% (95% CI: 2.8, 5.8) in the CAC score 0 group to 76.1% (95% CI: 70.3, 81.2) in the CAC score 400 or higher group. Revascularization rates increased from 1.7% to 46.2% across the same groups (P < .001). The CAC score 0 group had a lower MACE risk (0.5%; HR, 0.08 [95% CI: 0.02, 0.30]; P < .001), as did the 1-399 CAC score group (1.9%; HR, 0.27 [95% CI: 0.13, 0.59]; P = .001), compared with the 400 or higher CAC score group (6.8%). No significant difference in MACE between sexes was observed (P = .68). Conclusion: In participants with stable chest pain initially referred for ICA, a CAC score of 0 showed very low risk of MACE, and higher CAC scores showed increasing risk of obstructive CAD, revascularization, and MACE at follow-up.

AB - Background: Coronary artery calcium (CAC) has prognostic value for major adverse cardiovascular events (MACE) in asymptomatic individuals, whereas its role in symptomatic patients is less clear. Purpose: To assess the prognostic value of CAC scoring for MACE in participants with stable chest pain initially referred for invasive coronary angiography (ICA). Materials and Methods: This prespecified subgroup analysis from the Diagnostic Imaging Strategies for Patients With Stable Chest Pain and Intermediate Risk of Coronary Artery Disease (DISCHARGE) trial, conducted between October 2015 and April 2019 across 26 centers in 16 countries, focused on adult patients with stable chest pain referred for ICA. Participants were randomly assigned to undergo either ICA or coronary CT. CAC scores from noncontrast CT scans were categorized into low, intermediate, and high groups based on scores of 0, 1-399, and 400 or higher, respectively. The end point of the study was the occurrence of MACE (myocardial infarction, stroke, and cardiovascular death) over a median 3.5-year follow-up, analyzed using Cox proportional hazard regression tests. Results: The study involved 1749 participants (mean age, 60 years ± 10 [SD]; 992 female). The prevalence of obstructive coronary artery disease (CAD) at CT angiography rose from 4.1% (95% CI: 2.8, 5.8) in the CAC score 0 group to 76.1% (95% CI: 70.3, 81.2) in the CAC score 400 or higher group. Revascularization rates increased from 1.7% to 46.2% across the same groups (P < .001). The CAC score 0 group had a lower MACE risk (0.5%; HR, 0.08 [95% CI: 0.02, 0.30]; P < .001), as did the 1-399 CAC score group (1.9%; HR, 0.27 [95% CI: 0.13, 0.59]; P = .001), compared with the 400 or higher CAC score group (6.8%). No significant difference in MACE between sexes was observed (P = .68). Conclusion: In participants with stable chest pain initially referred for ICA, a CAC score of 0 showed very low risk of MACE, and higher CAC scores showed increasing risk of obstructive CAD, revascularization, and MACE at follow-up.

U2 - 10.1148/radiol.231557

DO - 10.1148/radiol.231557

M3 - Journal article

C2 - 38441097

AN - SCOPUS:85188799904

VL - 310

JO - Radiology

JF - Radiology

SN - 0033-8419

IS - 3

M1 - e231557

ER -

ID: 388022150