Coronary Artery Calcium Score Predicts Major Adverse Cardiovascular Events in Stable Chest Pain
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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Coronary Artery Calcium Score Predicts Major Adverse Cardiovascular Events in Stable Chest Pain. / Biavati, Federico; Saba, Luca; Boussoussou, Melinda; Kofoed, Klaus F.; Benedek, Theodora; Donnelly, Patrick; Rodríguez-Palomares, José; Erglis, Andrejs; Štěchovský, Cyril; Šakalytė, Gintarė; Ađić, Nada Čemerlić; Gutberlet, Matthias; Dodd, Jonathan D.; Diez, Ignacio; Davis, Gershan; Zimmermann, Elke; Kępka, Cezary; Vidakovic, Radosav; Francone, Marco; Ilnicka-Suckiel, Małgorzata; Plank, Fabian; Knuuti, Juhani; Faria, Rita; Schröder, Stephen; Berry, Colin; Ruzsics, Balazs; Rieckmann, Nina; Kubiak, Christine; Hansen, Kristian Schultz; Müller-Nordhorn, Jacqueline; Maurovich-Horvat, Pál; Sigvardsen, Per E.; Benedek, Imre; Orr, Clare; Valente, Filipa Xavier; Zvaigzne, Ligita; Suchánek, Vojtěch; Jankauskas, Antanas; Ađić, Filip; Woinke, Michael; Cadogan, Diarmaid; Lecumberri, Iñigo; Thwaite, Erica; Kruk, Mariusz; Neskovic, Aleksandar N.; Mancone, Massimo; Kuśmierz, Donata; Feuchtner, Gudrun; Pietilä, Mikko; Ribeiro, Vasco Gama; Drosch, Tanja; Delles, Christian; Cau, Riccardo; Fisher, Michael; Merkely, Bela; Kragelund, Charlotte; Aurelian, Rosca; Kelly, Stephanie; del Blanco, Bruno García; Rubio, Ainhoa; Szilveszter, Bálint; Hove, Jens D.; Rodean, Ioana; Regan, Susan; Calabria, Hug Cuéllar; Édes, István Ferenc; Larsen, Linnea; Hodas, Roxana; Napp, Adriane E.; Haase, Robert; Feger, Sarah; Mohamed, Mahmoud; Serna-Higuita, Lina M.; Neumann, Konrad; Dreger, Henryk; Rief, Matthias; Wieske, Viktoria; Budoff, Matthew J.; Estrella, Melanie; Martus, Peter; Bosserdt, Maria; Dewey, Marc.
I: Radiology, Bind 310, Nr. 3, e231557, 2024.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Coronary Artery Calcium Score Predicts Major Adverse Cardiovascular Events in Stable Chest Pain
AU - Biavati, Federico
AU - Saba, Luca
AU - Boussoussou, Melinda
AU - Kofoed, Klaus F.
AU - Benedek, Theodora
AU - Donnelly, Patrick
AU - Rodríguez-Palomares, José
AU - Erglis, Andrejs
AU - Štěchovský, Cyril
AU - Šakalytė, Gintarė
AU - Ađić, Nada Čemerlić
AU - Gutberlet, Matthias
AU - Dodd, Jonathan D.
AU - Diez, Ignacio
AU - Davis, Gershan
AU - Zimmermann, Elke
AU - Kępka, Cezary
AU - Vidakovic, Radosav
AU - Francone, Marco
AU - Ilnicka-Suckiel, Małgorzata
AU - Plank, Fabian
AU - Knuuti, Juhani
AU - Faria, Rita
AU - Schröder, Stephen
AU - Berry, Colin
AU - Ruzsics, Balazs
AU - Rieckmann, Nina
AU - Kubiak, Christine
AU - Hansen, Kristian Schultz
AU - Müller-Nordhorn, Jacqueline
AU - Maurovich-Horvat, Pál
AU - Sigvardsen, Per E.
AU - Benedek, Imre
AU - Orr, Clare
AU - Valente, Filipa Xavier
AU - Zvaigzne, Ligita
AU - Suchánek, Vojtěch
AU - Jankauskas, Antanas
AU - Ađić, Filip
AU - Woinke, Michael
AU - Cadogan, Diarmaid
AU - Lecumberri, Iñigo
AU - Thwaite, Erica
AU - Kruk, Mariusz
AU - Neskovic, Aleksandar N.
AU - Mancone, Massimo
AU - Kuśmierz, Donata
AU - Feuchtner, Gudrun
AU - Pietilä, Mikko
AU - Ribeiro, Vasco Gama
AU - Drosch, Tanja
AU - Delles, Christian
AU - Cau, Riccardo
AU - Fisher, Michael
AU - Merkely, Bela
AU - Kragelund, Charlotte
AU - Aurelian, Rosca
AU - Kelly, Stephanie
AU - del Blanco, Bruno García
AU - Rubio, Ainhoa
AU - Szilveszter, Bálint
AU - Hove, Jens D.
AU - Rodean, Ioana
AU - Regan, Susan
AU - Calabria, Hug Cuéllar
AU - Édes, István Ferenc
AU - Larsen, Linnea
AU - Hodas, Roxana
AU - Napp, Adriane E.
AU - Haase, Robert
AU - Feger, Sarah
AU - Mohamed, Mahmoud
AU - Serna-Higuita, Lina M.
AU - Neumann, Konrad
AU - Dreger, Henryk
AU - Rief, Matthias
AU - Wieske, Viktoria
AU - Budoff, Matthew J.
AU - Estrella, Melanie
AU - Martus, Peter
AU - Bosserdt, Maria
AU - Dewey, Marc
N1 - Publisher Copyright: © RSNA, 2024.
PY - 2024
Y1 - 2024
N2 - Background: Coronary artery calcium (CAC) has prognostic value for major adverse cardiovascular events (MACE) in asymptomatic individuals, whereas its role in symptomatic patients is less clear. Purpose: To assess the prognostic value of CAC scoring for MACE in participants with stable chest pain initially referred for invasive coronary angiography (ICA). Materials and Methods: This prespecified subgroup analysis from the Diagnostic Imaging Strategies for Patients With Stable Chest Pain and Intermediate Risk of Coronary Artery Disease (DISCHARGE) trial, conducted between October 2015 and April 2019 across 26 centers in 16 countries, focused on adult patients with stable chest pain referred for ICA. Participants were randomly assigned to undergo either ICA or coronary CT. CAC scores from noncontrast CT scans were categorized into low, intermediate, and high groups based on scores of 0, 1-399, and 400 or higher, respectively. The end point of the study was the occurrence of MACE (myocardial infarction, stroke, and cardiovascular death) over a median 3.5-year follow-up, analyzed using Cox proportional hazard regression tests. Results: The study involved 1749 participants (mean age, 60 years ± 10 [SD]; 992 female). The prevalence of obstructive coronary artery disease (CAD) at CT angiography rose from 4.1% (95% CI: 2.8, 5.8) in the CAC score 0 group to 76.1% (95% CI: 70.3, 81.2) in the CAC score 400 or higher group. Revascularization rates increased from 1.7% to 46.2% across the same groups (P < .001). The CAC score 0 group had a lower MACE risk (0.5%; HR, 0.08 [95% CI: 0.02, 0.30]; P < .001), as did the 1-399 CAC score group (1.9%; HR, 0.27 [95% CI: 0.13, 0.59]; P = .001), compared with the 400 or higher CAC score group (6.8%). No significant difference in MACE between sexes was observed (P = .68). Conclusion: In participants with stable chest pain initially referred for ICA, a CAC score of 0 showed very low risk of MACE, and higher CAC scores showed increasing risk of obstructive CAD, revascularization, and MACE at follow-up.
AB - Background: Coronary artery calcium (CAC) has prognostic value for major adverse cardiovascular events (MACE) in asymptomatic individuals, whereas its role in symptomatic patients is less clear. Purpose: To assess the prognostic value of CAC scoring for MACE in participants with stable chest pain initially referred for invasive coronary angiography (ICA). Materials and Methods: This prespecified subgroup analysis from the Diagnostic Imaging Strategies for Patients With Stable Chest Pain and Intermediate Risk of Coronary Artery Disease (DISCHARGE) trial, conducted between October 2015 and April 2019 across 26 centers in 16 countries, focused on adult patients with stable chest pain referred for ICA. Participants were randomly assigned to undergo either ICA or coronary CT. CAC scores from noncontrast CT scans were categorized into low, intermediate, and high groups based on scores of 0, 1-399, and 400 or higher, respectively. The end point of the study was the occurrence of MACE (myocardial infarction, stroke, and cardiovascular death) over a median 3.5-year follow-up, analyzed using Cox proportional hazard regression tests. Results: The study involved 1749 participants (mean age, 60 years ± 10 [SD]; 992 female). The prevalence of obstructive coronary artery disease (CAD) at CT angiography rose from 4.1% (95% CI: 2.8, 5.8) in the CAC score 0 group to 76.1% (95% CI: 70.3, 81.2) in the CAC score 400 or higher group. Revascularization rates increased from 1.7% to 46.2% across the same groups (P < .001). The CAC score 0 group had a lower MACE risk (0.5%; HR, 0.08 [95% CI: 0.02, 0.30]; P < .001), as did the 1-399 CAC score group (1.9%; HR, 0.27 [95% CI: 0.13, 0.59]; P = .001), compared with the 400 or higher CAC score group (6.8%). No significant difference in MACE between sexes was observed (P = .68). Conclusion: In participants with stable chest pain initially referred for ICA, a CAC score of 0 showed very low risk of MACE, and higher CAC scores showed increasing risk of obstructive CAD, revascularization, and MACE at follow-up.
U2 - 10.1148/radiol.231557
DO - 10.1148/radiol.231557
M3 - Journal article
C2 - 38441097
AN - SCOPUS:85188799904
VL - 310
JO - Radiology
JF - Radiology
SN - 0033-8419
IS - 3
M1 - e231557
ER -
ID: 388022150