Continuing occurrence of vancomycin resistance determinants in Danish pig farms 20 years after removing exposure to avoparcin
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Standard
Continuing occurrence of vancomycin resistance determinants in Danish pig farms 20 years after removing exposure to avoparcin. / Birkegård, Anna Camilla; Græsbøll, Kaare; Clasen, Julie; Halasa, Tariq; Toft, Nils; Folkesson, Anders.
I: Veterinary Microbiology, Bind 232, 2019, s. 84-88.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Continuing occurrence of vancomycin resistance determinants in Danish pig farms 20 years after removing exposure to avoparcin
AU - Birkegård, Anna Camilla
AU - Græsbøll, Kaare
AU - Clasen, Julie
AU - Halasa, Tariq
AU - Toft, Nils
AU - Folkesson, Anders
PY - 2019
Y1 - 2019
N2 - Vancomycin-resistant Enterococcus spp. is a major health problem worldwide and livestock have been implicated in constituting a reservoir for the transmission of vancomycin resistance to zoonotic pathogens. Vancomycin resistance determinants can be situated on mobile genetic elements and transferred between bacterial species The livestock reservoir must therefore be included in a risk assessment of the vancomycin resistance burden. Avoparcin, a vancomycin analogue, has not been used in Danish pig production for over 20 years and vancomycin has never been used. The objective of this study was to screen faecal samples from Danish pig farms for nine selected vancomycin resistance determinants. We found at least four different vancomycin resistance determinants in all screened Danish pig farms (665 finisher farms and 78 sow farms). The vancomycin resistance determinants present in vanB or vanG clusters were found at significantly different levels in sow and finisher farms. However, vanA was not detected in any of the farms. In conclusion, vancomycin resistance determinants are still present in Danish pig production 25 years after the ban on avoparcin use.
AB - Vancomycin-resistant Enterococcus spp. is a major health problem worldwide and livestock have been implicated in constituting a reservoir for the transmission of vancomycin resistance to zoonotic pathogens. Vancomycin resistance determinants can be situated on mobile genetic elements and transferred between bacterial species The livestock reservoir must therefore be included in a risk assessment of the vancomycin resistance burden. Avoparcin, a vancomycin analogue, has not been used in Danish pig production for over 20 years and vancomycin has never been used. The objective of this study was to screen faecal samples from Danish pig farms for nine selected vancomycin resistance determinants. We found at least four different vancomycin resistance determinants in all screened Danish pig farms (665 finisher farms and 78 sow farms). The vancomycin resistance determinants present in vanB or vanG clusters were found at significantly different levels in sow and finisher farms. However, vanA was not detected in any of the farms. In conclusion, vancomycin resistance determinants are still present in Danish pig production 25 years after the ban on avoparcin use.
KW - Antimicrobial resistance
KW - Avoparcin
KW - Glycopeptides
KW - Swine
U2 - 10.1016/j.vetmic.2019.04.007
DO - 10.1016/j.vetmic.2019.04.007
M3 - Journal article
C2 - 31030850
AN - SCOPUS:85064152014
VL - 232
SP - 84
EP - 88
JO - Veterinary Microbiology
JF - Veterinary Microbiology
SN - 0378-1135
ER -
ID: 231411722