Conjugated C-6 hydroxylated bile acids in serum relate to human metabolic health and gut Clostridia species

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Conjugated C-6 hydroxylated bile acids in serum relate to human metabolic health and gut Clostridia species. / Petersen, Anders Ø.; Julienne, Hanna; Hyötyläinen, Tuulia; Sen, Partho; Fan, Yong; Pedersen, Helle Krogh; Jäntti, Sirkku; Hansen, Tue H.; Nielsen, Trine; Jørgensen, Torben; Hansen, Torben; Myers, Pernille Neve; Nielsen, H. Bjørn; Ehrlich, S. Dusko; Orešič, Matej; Pedersen, Oluf.

I: Scientific Reports, Bind 11, Nr. 1, 13252, 2021.

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Harvard

Petersen, AØ, Julienne, H, Hyötyläinen, T, Sen, P, Fan, Y, Pedersen, HK, Jäntti, S, Hansen, TH, Nielsen, T, Jørgensen, T, Hansen, T, Myers, PN, Nielsen, HB, Ehrlich, SD, Orešič, M & Pedersen, O 2021, 'Conjugated C-6 hydroxylated bile acids in serum relate to human metabolic health and gut Clostridia species', Scientific Reports, bind 11, nr. 1, 13252. https://doi.org/10.1038/s41598-021-91482-y

APA

Petersen, A. Ø., Julienne, H., Hyötyläinen, T., Sen, P., Fan, Y., Pedersen, H. K., Jäntti, S., Hansen, T. H., Nielsen, T., Jørgensen, T., Hansen, T., Myers, P. N., Nielsen, H. B., Ehrlich, S. D., Orešič, M., & Pedersen, O. (2021). Conjugated C-6 hydroxylated bile acids in serum relate to human metabolic health and gut Clostridia species. Scientific Reports, 11(1), [13252]. https://doi.org/10.1038/s41598-021-91482-y

Vancouver

Petersen AØ, Julienne H, Hyötyläinen T, Sen P, Fan Y, Pedersen HK o.a. Conjugated C-6 hydroxylated bile acids in serum relate to human metabolic health and gut Clostridia species. Scientific Reports. 2021;11(1). 13252. https://doi.org/10.1038/s41598-021-91482-y

Author

Petersen, Anders Ø. ; Julienne, Hanna ; Hyötyläinen, Tuulia ; Sen, Partho ; Fan, Yong ; Pedersen, Helle Krogh ; Jäntti, Sirkku ; Hansen, Tue H. ; Nielsen, Trine ; Jørgensen, Torben ; Hansen, Torben ; Myers, Pernille Neve ; Nielsen, H. Bjørn ; Ehrlich, S. Dusko ; Orešič, Matej ; Pedersen, Oluf. / Conjugated C-6 hydroxylated bile acids in serum relate to human metabolic health and gut Clostridia species. I: Scientific Reports. 2021 ; Bind 11, Nr. 1.

Bibtex

@article{bd1dea46cd0e4698b1911c141e49ebfa,
title = "Conjugated C-6 hydroxylated bile acids in serum relate to human metabolic health and gut Clostridia species",
abstract = "Knowledge about in vivo effects of human circulating C-6 hydroxylated bile acids (BAs), also called muricholic acids, is sparse. It is unsettled if the gut microbiome might contribute to their biosynthesis. Here, we measured a range of serum BAs and related them to markers of human metabolic health and the gut microbiome. We examined 283 non-obese and obese Danish adults from the MetaHit study. Fasting concentrations of serum BAs were quantified using ultra-performance liquid chromatography-tandem mass-spectrometry. The gut microbiome was characterized with shotgun metagenomic sequencing and genome-scale metabolic modeling. We find that tauro- and glycohyocholic acid correlated inversely with body mass index (P = 4.1e-03, P = 1.9e-05, respectively), waist circumference (P = 0.017, P = 1.1e-04, respectively), body fat percentage (P = 2.5e-03, P = 2.3e-06, respectively), insulin resistance (P = 0.051, P = 4.6e-4, respectively), fasting concentrations of triglycerides (P = 0.06, P = 9.2e-4, respectively) and leptin (P = 0.067, P = 9.2e-4). Tauro- and glycohyocholic acids, and tauro-a-muricholic acid were directly linked with a distinct gut microbial community primarily composed of Clostridia species (P = 0.037, P = 0.013, P = 0.027, respectively). We conclude that serum conjugated C-6-hydroxylated BAs associate with measures of human metabolic health and gut communities of Clostridia species. The findings merit preclinical interventions and human feasibility studies to explore the therapeutic potential of these BAs in obesity and type 2 diabetes.",
keywords = "MICROBIOME, RECEPTOR, SAMPLES, IMPACT, BLOOD",
author = "Petersen, {Anders {\O}.} and Hanna Julienne and Tuulia Hy{\"o}tyl{\"a}inen and Partho Sen and Yong Fan and Pedersen, {Helle Krogh} and Sirkku J{\"a}ntti and Hansen, {Tue H.} and Trine Nielsen and Torben J{\o}rgensen and Torben Hansen and Myers, {Pernille Neve} and Nielsen, {H. Bj{\o}rn} and Ehrlich, {S. Dusko} and Matej Ore{\v s}i{\v c} and Oluf Pedersen",
year = "2021",
doi = "10.1038/s41598-021-91482-y",
language = "English",
volume = "11",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "nature publishing group",
number = "1",

}

RIS

TY - JOUR

T1 - Conjugated C-6 hydroxylated bile acids in serum relate to human metabolic health and gut Clostridia species

AU - Petersen, Anders Ø.

AU - Julienne, Hanna

AU - Hyötyläinen, Tuulia

AU - Sen, Partho

AU - Fan, Yong

AU - Pedersen, Helle Krogh

AU - Jäntti, Sirkku

AU - Hansen, Tue H.

AU - Nielsen, Trine

AU - Jørgensen, Torben

AU - Hansen, Torben

AU - Myers, Pernille Neve

AU - Nielsen, H. Bjørn

AU - Ehrlich, S. Dusko

AU - Orešič, Matej

AU - Pedersen, Oluf

PY - 2021

Y1 - 2021

N2 - Knowledge about in vivo effects of human circulating C-6 hydroxylated bile acids (BAs), also called muricholic acids, is sparse. It is unsettled if the gut microbiome might contribute to their biosynthesis. Here, we measured a range of serum BAs and related them to markers of human metabolic health and the gut microbiome. We examined 283 non-obese and obese Danish adults from the MetaHit study. Fasting concentrations of serum BAs were quantified using ultra-performance liquid chromatography-tandem mass-spectrometry. The gut microbiome was characterized with shotgun metagenomic sequencing and genome-scale metabolic modeling. We find that tauro- and glycohyocholic acid correlated inversely with body mass index (P = 4.1e-03, P = 1.9e-05, respectively), waist circumference (P = 0.017, P = 1.1e-04, respectively), body fat percentage (P = 2.5e-03, P = 2.3e-06, respectively), insulin resistance (P = 0.051, P = 4.6e-4, respectively), fasting concentrations of triglycerides (P = 0.06, P = 9.2e-4, respectively) and leptin (P = 0.067, P = 9.2e-4). Tauro- and glycohyocholic acids, and tauro-a-muricholic acid were directly linked with a distinct gut microbial community primarily composed of Clostridia species (P = 0.037, P = 0.013, P = 0.027, respectively). We conclude that serum conjugated C-6-hydroxylated BAs associate with measures of human metabolic health and gut communities of Clostridia species. The findings merit preclinical interventions and human feasibility studies to explore the therapeutic potential of these BAs in obesity and type 2 diabetes.

AB - Knowledge about in vivo effects of human circulating C-6 hydroxylated bile acids (BAs), also called muricholic acids, is sparse. It is unsettled if the gut microbiome might contribute to their biosynthesis. Here, we measured a range of serum BAs and related them to markers of human metabolic health and the gut microbiome. We examined 283 non-obese and obese Danish adults from the MetaHit study. Fasting concentrations of serum BAs were quantified using ultra-performance liquid chromatography-tandem mass-spectrometry. The gut microbiome was characterized with shotgun metagenomic sequencing and genome-scale metabolic modeling. We find that tauro- and glycohyocholic acid correlated inversely with body mass index (P = 4.1e-03, P = 1.9e-05, respectively), waist circumference (P = 0.017, P = 1.1e-04, respectively), body fat percentage (P = 2.5e-03, P = 2.3e-06, respectively), insulin resistance (P = 0.051, P = 4.6e-4, respectively), fasting concentrations of triglycerides (P = 0.06, P = 9.2e-4, respectively) and leptin (P = 0.067, P = 9.2e-4). Tauro- and glycohyocholic acids, and tauro-a-muricholic acid were directly linked with a distinct gut microbial community primarily composed of Clostridia species (P = 0.037, P = 0.013, P = 0.027, respectively). We conclude that serum conjugated C-6-hydroxylated BAs associate with measures of human metabolic health and gut communities of Clostridia species. The findings merit preclinical interventions and human feasibility studies to explore the therapeutic potential of these BAs in obesity and type 2 diabetes.

KW - MICROBIOME

KW - RECEPTOR

KW - SAMPLES

KW - IMPACT

KW - BLOOD

U2 - 10.1038/s41598-021-91482-y

DO - 10.1038/s41598-021-91482-y

M3 - Journal article

C2 - 34168163

VL - 11

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

IS - 1

M1 - 13252

ER -

ID: 274522656