Concentrations of the acute phase reactants high-sensitive C-reactive protein and YKL-40 and of interleukin-6 before and after treatment in patients with acromegaly and growth hormone deficiency
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Concentrations of the acute phase reactants high-sensitive C-reactive protein and YKL-40 and of interleukin-6 before and after treatment in patients with acromegaly and growth hormone deficiency. / Andreassen, Mikkel; Vestergaard, Henrik; Kristensen, Lars Østergaard.
I: Clinical Endocrinology, Bind 67, Nr. 6, 12.2007, s. 909-16.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Concentrations of the acute phase reactants high-sensitive C-reactive protein and YKL-40 and of interleukin-6 before and after treatment in patients with acromegaly and growth hormone deficiency
AU - Andreassen, Mikkel
AU - Vestergaard, Henrik
AU - Kristensen, Lars Østergaard
PY - 2007/12
Y1 - 2007/12
N2 - Acromegaly is accompanied by increased cardiovascular mortality and a cluster of proatherogenic risk factors. In the general population, ischaemic heart disease (IHD) is associated with elevated levels of inflammatory markers. The acute phase reactant (APR) C-reactive protein (CRP) has been reported to be reduced in acromegaly and increase after treatment, suggesting that excess of GH/IGF-I could have anti-inflammatory effects. This is in accordance with results obtained in patients with growth hormone deficiency (GHD), where increased levels of CRP have been reported.
AB - Acromegaly is accompanied by increased cardiovascular mortality and a cluster of proatherogenic risk factors. In the general population, ischaemic heart disease (IHD) is associated with elevated levels of inflammatory markers. The acute phase reactant (APR) C-reactive protein (CRP) has been reported to be reduced in acromegaly and increase after treatment, suggesting that excess of GH/IGF-I could have anti-inflammatory effects. This is in accordance with results obtained in patients with growth hormone deficiency (GHD), where increased levels of CRP have been reported.
KW - Acromegaly
KW - Adipokines
KW - Adolescent
KW - Adult
KW - C-Reactive Protein
KW - Case-Control Studies
KW - Dwarfism, Pituitary
KW - Female
KW - Human Growth Hormone
KW - Humans
KW - Insulin-Like Growth Factor I
KW - Interleukin-6
KW - Lectins
KW - Male
KW - Middle Aged
KW - Young Adult
U2 - 10.1111/j.1365-2265.2007.02986.x
DO - 10.1111/j.1365-2265.2007.02986.x
M3 - Journal article
C2 - 17727678
VL - 67
SP - 909
EP - 916
JO - Clinical Endocrinology
JF - Clinical Endocrinology
SN - 0300-0664
IS - 6
ER -
ID: 92190487