TY - JOUR

T1 - Coenzyme Q10 does not improve peripheral insulin sensitivity in statin-treated men and women

T2 - the LIFESTAT study

AU - Kuhlman, Anja Birk

AU - Morville, Thomas

AU - Dohlmann, Tine Lovsø

AU - Hansen, Maria

AU - Kelly, Bo

AU - Helge, Jørn Wulff

AU - Dela, Flemming

N1 - Corrigendum: https://www.nrcresearchpress.com/doi/10.1139/apnm-2019-0659#.Xd5cJtXcDVg

PY - 2019

Y1 - 2019

N2 - Simvastatin is a cholesterol-lowering drug that is prescribed to lower the risk of cardiovascular disease following high levels of blood cholesterol. There is a possible risk of new onset diabetes mellitus with statin treatment but the mechanisms behind are unknown. Coenzyme Q10 (CoQ10) supplementation has been found to improve glucose homeostasis in various patient populations and may increase muscle GLUT4 content. Our aim was to investigate whether eight weeks of CoQ10 supplementation can improve glucose homeostasis in simvastatin treated subjects. Thirty-five men and women in treatment with minimum 40 mg of simvastatin daily were randomized to receive either 2 x 200 mg/d of CoQ10 supplementation or placebo for eight weeks. Glucose homeostasis was investigated with fasting blood samples, OGTT and IVGTT. Insulin sensitivity was assessed with the hyperinsulinemic, euglycemic clamp. Different indices were calculated from fasting samples and OGTT as secondary measures of insulin sensitivity. A muscle biopsy was obtained from the vastus lateralis muscle for muscle protein analyzes. There were no changes in body composition, fasting plasma insulin, fasting plasma glucose or 3hr-glucose with intervention, but HbA1c decreased with time. Glucose homeostasis measured as the AUC for glucose, insulin and C-peptide during OGTT was unchanged after intervention. Insulin secretory capacity was also unaltered after CoQ10 supplementation. Insulin sensitivity was unchanged but hepatic insulin sensitivity (HOMA2-%S) increased. No changes in muscle GLUT4 content was observed after intervention. CoQ10 supplementation does not change muscle GLUT4 content, insulin sensitivity or secretory capacity, but hepatic insulin sensitivity may improve.

AB - Simvastatin is a cholesterol-lowering drug that is prescribed to lower the risk of cardiovascular disease following high levels of blood cholesterol. There is a possible risk of new onset diabetes mellitus with statin treatment but the mechanisms behind are unknown. Coenzyme Q10 (CoQ10) supplementation has been found to improve glucose homeostasis in various patient populations and may increase muscle GLUT4 content. Our aim was to investigate whether eight weeks of CoQ10 supplementation can improve glucose homeostasis in simvastatin treated subjects. Thirty-five men and women in treatment with minimum 40 mg of simvastatin daily were randomized to receive either 2 x 200 mg/d of CoQ10 supplementation or placebo for eight weeks. Glucose homeostasis was investigated with fasting blood samples, OGTT and IVGTT. Insulin sensitivity was assessed with the hyperinsulinemic, euglycemic clamp. Different indices were calculated from fasting samples and OGTT as secondary measures of insulin sensitivity. A muscle biopsy was obtained from the vastus lateralis muscle for muscle protein analyzes. There were no changes in body composition, fasting plasma insulin, fasting plasma glucose or 3hr-glucose with intervention, but HbA1c decreased with time. Glucose homeostasis measured as the AUC for glucose, insulin and C-peptide during OGTT was unchanged after intervention. Insulin secretory capacity was also unaltered after CoQ10 supplementation. Insulin sensitivity was unchanged but hepatic insulin sensitivity (HOMA2-%S) increased. No changes in muscle GLUT4 content was observed after intervention. CoQ10 supplementation does not change muscle GLUT4 content, insulin sensitivity or secretory capacity, but hepatic insulin sensitivity may improve.

U2 - 10.1139/apnm-2018-0488

DO - 10.1139/apnm-2018-0488

M3 - Journal article

C2 - 30273493

VL - 44

SP - 485

EP - 492

JO - Applied Physiology, Nutrition and Metabolism

JF - Applied Physiology, Nutrition and Metabolism

SN - 1715-5312

ER -