Classification of death causes after transplantation (CLASS): Evaluation of methodology and initial results

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Standard

Classification of death causes after transplantation (CLASS) : Evaluation of methodology and initial results. / Wareham, Neval Ete; Da Cunha-Bang, Caspar; Borges, Álvaro H; Ekenberg, Christina; Gerstoft, Jan; Gustafsson, Finn; Hansen, Ditte; Heilmann, Carsten; Helleberg, Marie; Hillingsø, Jens; Krohn, Paul Suno; Lodding, Isabelle Paula; Lund, Thomas Kromann; Lundgren, Louise; Mocroft, Amanda; Perch, Michael; Petersen, Søren Lykke; Petruskevicius, Irma; Rasmussen, Allan; Rossing, Kasper; Rostved, Andreas A; Sengeløv, Henrik; Sørensen, Vibeke Rømming; Sørensen, Søren Schwartz; Lundgren, Jens D.

I: Medicine, Bind 97, Nr. 29, e11564, 2018.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Wareham, NE, Da Cunha-Bang, C, Borges, ÁH, Ekenberg, C, Gerstoft, J, Gustafsson, F, Hansen, D, Heilmann, C, Helleberg, M, Hillingsø, J, Krohn, PS, Lodding, IP, Lund, TK, Lundgren, L, Mocroft, A, Perch, M, Petersen, SL, Petruskevicius, I, Rasmussen, A, Rossing, K, Rostved, AA, Sengeløv, H, Sørensen, VR, Sørensen, SS & Lundgren, JD 2018, 'Classification of death causes after transplantation (CLASS): Evaluation of methodology and initial results', Medicine, bind 97, nr. 29, e11564. https://doi.org/10.1097/MD.0000000000011564

APA

Wareham, N. E., Da Cunha-Bang, C., Borges, Á. H., Ekenberg, C., Gerstoft, J., Gustafsson, F., ... Lundgren, J. D. (2018). Classification of death causes after transplantation (CLASS): Evaluation of methodology and initial results. Medicine, 97(29), [e11564]. https://doi.org/10.1097/MD.0000000000011564

Vancouver

Wareham NE, Da Cunha-Bang C, Borges ÁH, Ekenberg C, Gerstoft J, Gustafsson F o.a. Classification of death causes after transplantation (CLASS): Evaluation of methodology and initial results. Medicine. 2018;97(29). e11564. https://doi.org/10.1097/MD.0000000000011564

Author

Wareham, Neval Ete ; Da Cunha-Bang, Caspar ; Borges, Álvaro H ; Ekenberg, Christina ; Gerstoft, Jan ; Gustafsson, Finn ; Hansen, Ditte ; Heilmann, Carsten ; Helleberg, Marie ; Hillingsø, Jens ; Krohn, Paul Suno ; Lodding, Isabelle Paula ; Lund, Thomas Kromann ; Lundgren, Louise ; Mocroft, Amanda ; Perch, Michael ; Petersen, Søren Lykke ; Petruskevicius, Irma ; Rasmussen, Allan ; Rossing, Kasper ; Rostved, Andreas A ; Sengeløv, Henrik ; Sørensen, Vibeke Rømming ; Sørensen, Søren Schwartz ; Lundgren, Jens D. / Classification of death causes after transplantation (CLASS) : Evaluation of methodology and initial results. I: Medicine. 2018 ; Bind 97, Nr. 29.

Bibtex

@article{a555228fe452497b93366332e377589b,
title = "Classification of death causes after transplantation (CLASS): Evaluation of methodology and initial results",
abstract = "Correct classification of death causes is an important component of transplant trials.We aimed to develop and validate a system to classify causes of death in hematopoietic stem cell (HSCT) and solid organ (SOT) transplant recipients.Case record forms (CRF) of fatal cases were completed, including investigator-designated cause of death. Deaths occurring in 2010 to 2013 were used for derivation; and were validated by deaths occurring in 2013 to 2015. Underlying cause of death (referred to as recorded underlying cause) was determined through a central adjudication process involving 2 external reviewers, and subsequently compared with the Danish National Death Cause Registry.Three hundred eighty-eight recipients died 2010 to 2015 (196 [51{\%}] SOT and 192 [49{\%}] HSCT). The main recorded underlying causes of death among SOT and HSCT were classified as cancer (20{\%}, 48{\%}), graft rejection/failure/graft-versus-host-disease (35{\%}, 28{\%}), and infections (20{\%}, 11{\%}). Kappa between the investigator-designated and the recorded underlying cause of death was 0.74 (95{\%} CI 0.69-0.80) in derivation and comparable in the validation cohort. Death causes were concordant with the Danish National Death Cause Registry in 37.2{\%} (95{\%} CI 31.5-42.9) and 38.4{\%} (95{\%} CI 28.8-48.0) in the derivation and validation cohorts, respectively.We developed and validated a method to systematically and reliably classify the underlying cause of death among transplant recipients. There was a high degree of discordance between this classification and that in the Danish National Death Cause Registry.",
keywords = "Adult, Aged, Cause of Death, Denmark, Female, Humans, Male, Middle Aged, Registries, Transplant Recipients/statistics & numerical data, Transplantation/mortality",
author = "Wareham, {Neval Ete} and {Da Cunha-Bang}, Caspar and Borges, {{\'A}lvaro H} and Christina Ekenberg and Jan Gerstoft and Finn Gustafsson and Ditte Hansen and Carsten Heilmann and Marie Helleberg and Jens Hillings{\o} and Krohn, {Paul Suno} and Lodding, {Isabelle Paula} and Lund, {Thomas Kromann} and Louise Lundgren and Amanda Mocroft and Michael Perch and Petersen, {S{\o}ren Lykke} and Irma Petruskevicius and Allan Rasmussen and Kasper Rossing and Rostved, {Andreas A} and Henrik Sengel{\o}v and S{\o}rensen, {Vibeke R{\o}mming} and S{\o}rensen, {S{\o}ren Schwartz} and Lundgren, {Jens D.}",
year = "2018",
doi = "10.1097/MD.0000000000011564",
language = "English",
volume = "97",
journal = "Medicine (Baltimore)",
issn = "0025-7974",
publisher = "Wolters Kluwer Health, Inc.",
number = "29",

}

RIS

TY - JOUR

T1 - Classification of death causes after transplantation (CLASS)

T2 - Evaluation of methodology and initial results

AU - Wareham, Neval Ete

AU - Da Cunha-Bang, Caspar

AU - Borges, Álvaro H

AU - Ekenberg, Christina

AU - Gerstoft, Jan

AU - Gustafsson, Finn

AU - Hansen, Ditte

AU - Heilmann, Carsten

AU - Helleberg, Marie

AU - Hillingsø, Jens

AU - Krohn, Paul Suno

AU - Lodding, Isabelle Paula

AU - Lund, Thomas Kromann

AU - Lundgren, Louise

AU - Mocroft, Amanda

AU - Perch, Michael

AU - Petersen, Søren Lykke

AU - Petruskevicius, Irma

AU - Rasmussen, Allan

AU - Rossing, Kasper

AU - Rostved, Andreas A

AU - Sengeløv, Henrik

AU - Sørensen, Vibeke Rømming

AU - Sørensen, Søren Schwartz

AU - Lundgren, Jens D.

PY - 2018

Y1 - 2018

N2 - Correct classification of death causes is an important component of transplant trials.We aimed to develop and validate a system to classify causes of death in hematopoietic stem cell (HSCT) and solid organ (SOT) transplant recipients.Case record forms (CRF) of fatal cases were completed, including investigator-designated cause of death. Deaths occurring in 2010 to 2013 were used for derivation; and were validated by deaths occurring in 2013 to 2015. Underlying cause of death (referred to as recorded underlying cause) was determined through a central adjudication process involving 2 external reviewers, and subsequently compared with the Danish National Death Cause Registry.Three hundred eighty-eight recipients died 2010 to 2015 (196 [51%] SOT and 192 [49%] HSCT). The main recorded underlying causes of death among SOT and HSCT were classified as cancer (20%, 48%), graft rejection/failure/graft-versus-host-disease (35%, 28%), and infections (20%, 11%). Kappa between the investigator-designated and the recorded underlying cause of death was 0.74 (95% CI 0.69-0.80) in derivation and comparable in the validation cohort. Death causes were concordant with the Danish National Death Cause Registry in 37.2% (95% CI 31.5-42.9) and 38.4% (95% CI 28.8-48.0) in the derivation and validation cohorts, respectively.We developed and validated a method to systematically and reliably classify the underlying cause of death among transplant recipients. There was a high degree of discordance between this classification and that in the Danish National Death Cause Registry.

AB - Correct classification of death causes is an important component of transplant trials.We aimed to develop and validate a system to classify causes of death in hematopoietic stem cell (HSCT) and solid organ (SOT) transplant recipients.Case record forms (CRF) of fatal cases were completed, including investigator-designated cause of death. Deaths occurring in 2010 to 2013 were used for derivation; and were validated by deaths occurring in 2013 to 2015. Underlying cause of death (referred to as recorded underlying cause) was determined through a central adjudication process involving 2 external reviewers, and subsequently compared with the Danish National Death Cause Registry.Three hundred eighty-eight recipients died 2010 to 2015 (196 [51%] SOT and 192 [49%] HSCT). The main recorded underlying causes of death among SOT and HSCT were classified as cancer (20%, 48%), graft rejection/failure/graft-versus-host-disease (35%, 28%), and infections (20%, 11%). Kappa between the investigator-designated and the recorded underlying cause of death was 0.74 (95% CI 0.69-0.80) in derivation and comparable in the validation cohort. Death causes were concordant with the Danish National Death Cause Registry in 37.2% (95% CI 31.5-42.9) and 38.4% (95% CI 28.8-48.0) in the derivation and validation cohorts, respectively.We developed and validated a method to systematically and reliably classify the underlying cause of death among transplant recipients. There was a high degree of discordance between this classification and that in the Danish National Death Cause Registry.

KW - Adult

KW - Aged

KW - Cause of Death

KW - Denmark

KW - Female

KW - Humans

KW - Male

KW - Middle Aged

KW - Registries

KW - Transplant Recipients/statistics & numerical data

KW - Transplantation/mortality

U2 - 10.1097/MD.0000000000011564

DO - 10.1097/MD.0000000000011564

M3 - Journal article

C2 - 30024557

VL - 97

JO - Medicine (Baltimore)

JF - Medicine (Baltimore)

SN - 0025-7974

IS - 29

M1 - e11564

ER -

ID: 218709501