Chromatin-modifying proteins in cancer.
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Chromatin-modifying proteins in cancer. / Fog, Cathrine K; Jensen, Klaus T; Lund, Anders Henrik.
I: Acta Pathologica Microbiologica et Immunologica Scandinavica, Bind 115, Nr. 10, 2007, s. 1060-89.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › fagfællebedømt
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TY - JOUR
T1 - Chromatin-modifying proteins in cancer.
AU - Fog, Cathrine K
AU - Jensen, Klaus T
AU - Lund, Anders Henrik
N1 - Keywords: Chromatin; Epigenesis, Genetic; Genes, Tumor Suppressor; Genome, Human; Humans; Neoplasms; Protein Processing, Post-Translational
PY - 2007
Y1 - 2007
N2 - Chromatin-modifying proteins mold the genome into areas that are accessible for transcriptional activity and areas that are transcriptionally silent. This epigenetic gene regulation allows for different transcriptional programs to be conducted in different cell types at different timepoints-despite the fact that all cells in the organism contain the same genetic information. A large amount of data gathered over the last decades has demonstrated that deregulation of chromatin-modifying proteins is etiologically involved in the development and progression of cancer. Here we discuss how epigenetic alterations influence cancer development and review known cancer-associated alterations in chromatin-modifying proteins.
AB - Chromatin-modifying proteins mold the genome into areas that are accessible for transcriptional activity and areas that are transcriptionally silent. This epigenetic gene regulation allows for different transcriptional programs to be conducted in different cell types at different timepoints-despite the fact that all cells in the organism contain the same genetic information. A large amount of data gathered over the last decades has demonstrated that deregulation of chromatin-modifying proteins is etiologically involved in the development and progression of cancer. Here we discuss how epigenetic alterations influence cancer development and review known cancer-associated alterations in chromatin-modifying proteins.
U2 - 10.1111/j.1600-0463.2007.apm_776.xml.x
DO - 10.1111/j.1600-0463.2007.apm_776.xml.x
M3 - Journal article
C2 - 18042144
VL - 115
SP - 1060
EP - 1089
JO - A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica
JF - A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica
SN - 0903-4641
IS - 10
ER -
ID: 4075999