Chemical analyses of wasp-associated streptomyces bacteria reveal a prolific potential for natural products discovery

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Chemical analyses of wasp-associated streptomyces bacteria reveal a prolific potential for natural products discovery. / Poulsen, Michael; Oh, Dong-Chan; Clardy, Jon; Currie, Cameron R.

I: P L o S One, Bind 6, Nr. 2, 2011, s. e16763.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Poulsen, M, Oh, D-C, Clardy, J & Currie, CR 2011, 'Chemical analyses of wasp-associated streptomyces bacteria reveal a prolific potential for natural products discovery', P L o S One, bind 6, nr. 2, s. e16763. https://doi.org/10.1371/journal.pone.0016763

APA

Poulsen, M., Oh, D-C., Clardy, J., & Currie, C. R. (2011). Chemical analyses of wasp-associated streptomyces bacteria reveal a prolific potential for natural products discovery. P L o S One, 6(2), e16763. https://doi.org/10.1371/journal.pone.0016763

Vancouver

Poulsen M, Oh D-C, Clardy J, Currie CR. Chemical analyses of wasp-associated streptomyces bacteria reveal a prolific potential for natural products discovery. P L o S One. 2011;6(2):e16763. https://doi.org/10.1371/journal.pone.0016763

Author

Poulsen, Michael ; Oh, Dong-Chan ; Clardy, Jon ; Currie, Cameron R. / Chemical analyses of wasp-associated streptomyces bacteria reveal a prolific potential for natural products discovery. I: P L o S One. 2011 ; Bind 6, Nr. 2. s. e16763.

Bibtex

@article{33d7a407fc58436b82a22fa2fbf1b071,
title = "Chemical analyses of wasp-associated streptomyces bacteria reveal a prolific potential for natural products discovery",
abstract = "Identifying new sources for small molecule discovery is necessary to help mitigate the continuous emergence of antibiotic-resistance in pathogenic microbes. Recent studies indicate that one potentially rich source of novel natural products is Actinobacterial symbionts associated with social and solitary Hymenoptera. Here we test this possibility by examining two species of solitary mud dauber wasps, Sceliphron caementarium and Chalybion californicum. We performed enrichment isolations from 33 wasps and obtained more than 200 isolates of Streptomyces Actinobacteria. Chemical analyses of 15 of these isolates identified 11 distinct and structurally diverse secondary metabolites, including a novel polyunsaturated and polyoxygenated macrocyclic lactam, which we name sceliphrolactam. By pairing the 15 Streptomyces strains against a collection of fungi and bacteria, we document their antifungal and antibacterial activity. The prevalence and anti-microbial properties of Actinobacteria associated with these two solitary wasp species suggest the potential role of these Streptomyces as antibiotic-producing symbionts, potentially helping defend their wasp hosts from pathogenic microbes. Finding phylogenetically diverse and chemically prolific Actinobacteria from solitary wasps suggests that insect-associated Actinobacteria can provide a valuable source of novel natural products of pharmaceutical interest.",
author = "Michael Poulsen and Dong-Chan Oh and Jon Clardy and Currie, {Cameron R}",
year = "2011",
doi = "10.1371/journal.pone.0016763",
language = "English",
volume = "6",
pages = "e16763",
journal = "P L o S One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "2",

}

RIS

TY - JOUR

T1 - Chemical analyses of wasp-associated streptomyces bacteria reveal a prolific potential for natural products discovery

AU - Poulsen, Michael

AU - Oh, Dong-Chan

AU - Clardy, Jon

AU - Currie, Cameron R

PY - 2011

Y1 - 2011

N2 - Identifying new sources for small molecule discovery is necessary to help mitigate the continuous emergence of antibiotic-resistance in pathogenic microbes. Recent studies indicate that one potentially rich source of novel natural products is Actinobacterial symbionts associated with social and solitary Hymenoptera. Here we test this possibility by examining two species of solitary mud dauber wasps, Sceliphron caementarium and Chalybion californicum. We performed enrichment isolations from 33 wasps and obtained more than 200 isolates of Streptomyces Actinobacteria. Chemical analyses of 15 of these isolates identified 11 distinct and structurally diverse secondary metabolites, including a novel polyunsaturated and polyoxygenated macrocyclic lactam, which we name sceliphrolactam. By pairing the 15 Streptomyces strains against a collection of fungi and bacteria, we document their antifungal and antibacterial activity. The prevalence and anti-microbial properties of Actinobacteria associated with these two solitary wasp species suggest the potential role of these Streptomyces as antibiotic-producing symbionts, potentially helping defend their wasp hosts from pathogenic microbes. Finding phylogenetically diverse and chemically prolific Actinobacteria from solitary wasps suggests that insect-associated Actinobacteria can provide a valuable source of novel natural products of pharmaceutical interest.

AB - Identifying new sources for small molecule discovery is necessary to help mitigate the continuous emergence of antibiotic-resistance in pathogenic microbes. Recent studies indicate that one potentially rich source of novel natural products is Actinobacterial symbionts associated with social and solitary Hymenoptera. Here we test this possibility by examining two species of solitary mud dauber wasps, Sceliphron caementarium and Chalybion californicum. We performed enrichment isolations from 33 wasps and obtained more than 200 isolates of Streptomyces Actinobacteria. Chemical analyses of 15 of these isolates identified 11 distinct and structurally diverse secondary metabolites, including a novel polyunsaturated and polyoxygenated macrocyclic lactam, which we name sceliphrolactam. By pairing the 15 Streptomyces strains against a collection of fungi and bacteria, we document their antifungal and antibacterial activity. The prevalence and anti-microbial properties of Actinobacteria associated with these two solitary wasp species suggest the potential role of these Streptomyces as antibiotic-producing symbionts, potentially helping defend their wasp hosts from pathogenic microbes. Finding phylogenetically diverse and chemically prolific Actinobacteria from solitary wasps suggests that insect-associated Actinobacteria can provide a valuable source of novel natural products of pharmaceutical interest.

U2 - 10.1371/journal.pone.0016763

DO - 10.1371/journal.pone.0016763

M3 - Journal article

C2 - 21364940

VL - 6

SP - e16763

JO - P L o S One

JF - P L o S One

SN - 1932-6203

IS - 2

ER -

ID: 33075242