Chaperonin GroEL/GroES Over-Expression Promotes Aminoglycoside Resistance and Reduces Drug Susceptibilities in Escherichia coli Following Exposure to Sublethal Aminoglycoside Doses
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- fmicb-06-01572 (1)
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Antibiotic resistance is an increasing challenge to modern healthcare. Aminoglycoside antibiotics cause translation corruption and protein misfolding and aggregation in Escherichia coli. We previously showed that chaperonin GroEL/GroES depletion and over-expression sensitize and promote short-term tolerance, respectively, to this drug class. Here, we show that chaperonin GroEL/GroES over-expression accelerates acquisition of streptomycin resistance and reduces susceptibility to several other antibiotics following sub-lethal streptomycin antibiotic exposure. Chaperonin buffering could provide a novel mechanism for emergence of antibiotic resistance.
Originalsprog | Engelsk |
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Artikelnummer | 1572 |
Tidsskrift | Frontiers in Microbiology |
Vol/bind | 6 |
Sider (fra-til) | 1-5 |
ISSN | 1664-302X |
DOI | |
Status | Udgivet - 26 jan. 2016 |
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