Changes in mRNA for metabotropic glutamate receptors after transient cerebral ischaemia
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Changes in mRNA for metabotropic glutamate receptors after transient cerebral ischaemia. / Rosdahl, D; Seitzberg, D A; Christensen, Thomas; Balchen, T; Diemer, Nils Henrik.
I: NeuroReport, Bind 5, Nr. 5, 1994, s. 593-596.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › fagfællebedømt
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TY - JOUR
T1 - Changes in mRNA for metabotropic glutamate receptors after transient cerebral ischaemia
AU - Rosdahl, D
AU - Seitzberg, D A
AU - Christensen, Thomas
AU - Balchen, T
AU - Diemer, Nils Henrik
PY - 1994
Y1 - 1994
N2 - Using a rat 4-vessel occlusion model of cerebral ischaemia we studied the changes in the mRNA level for the metabotropic receptor subtypes mGluR1 alpha, mGluR1 beta, mGluR2, mGluR3, mGluR4, and mGluR5 by means of in situ hybridization with oligonucleotides. After 24 hours of reperfusion the mRNA levels were significantly increased for mGluR2 and mGluR4 while it was significantly decreased for mGluR5. These results suggest that vulnerable neurones react to an increased extracellular glutamate concentration by differential regulation of the mRNA for metabotropic glutamate receptor subtypes which perhaps reflects the different pre- or postsynaptic location and different involvement in ischaemic neurodegeneration.
AB - Using a rat 4-vessel occlusion model of cerebral ischaemia we studied the changes in the mRNA level for the metabotropic receptor subtypes mGluR1 alpha, mGluR1 beta, mGluR2, mGluR3, mGluR4, and mGluR5 by means of in situ hybridization with oligonucleotides. After 24 hours of reperfusion the mRNA levels were significantly increased for mGluR2 and mGluR4 while it was significantly decreased for mGluR5. These results suggest that vulnerable neurones react to an increased extracellular glutamate concentration by differential regulation of the mRNA for metabotropic glutamate receptor subtypes which perhaps reflects the different pre- or postsynaptic location and different involvement in ischaemic neurodegeneration.
KW - Animals
KW - Gene Expression Regulation
KW - In Situ Hybridization
KW - Ischemic Attack, Transient
KW - Male
KW - Nerve Tissue Proteins
KW - RNA, Messenger
KW - Rats
KW - Rats, Wistar
KW - Receptors, Glutamate
M3 - Journal article
C2 - 8025251
VL - 5
SP - 593
EP - 596
JO - NeuroReport
JF - NeuroReport
SN - 0959-4965
IS - 5
ER -
ID: 255192