Changes in mRNA for metabotropic glutamate receptors after transient cerebral ischaemia

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Standard

Changes in mRNA for metabotropic glutamate receptors after transient cerebral ischaemia. / Rosdahl, D; Seitzberg, D A; Christensen, Thomas; Balchen, T; Diemer, Nils Henrik.

I: NeuroReport, Bind 5, Nr. 5, 1994, s. 593-596.

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Harvard

Rosdahl, D, Seitzberg, DA, Christensen, T, Balchen, T & Diemer, NH 1994, 'Changes in mRNA for metabotropic glutamate receptors after transient cerebral ischaemia', NeuroReport, bind 5, nr. 5, s. 593-596.

APA

Rosdahl, D., Seitzberg, D. A., Christensen, T., Balchen, T., & Diemer, N. H. (1994). Changes in mRNA for metabotropic glutamate receptors after transient cerebral ischaemia. NeuroReport, 5(5), 593-596.

Vancouver

Rosdahl D, Seitzberg DA, Christensen T, Balchen T, Diemer NH. Changes in mRNA for metabotropic glutamate receptors after transient cerebral ischaemia. NeuroReport. 1994;5(5):593-596.

Author

Rosdahl, D ; Seitzberg, D A ; Christensen, Thomas ; Balchen, T ; Diemer, Nils Henrik. / Changes in mRNA for metabotropic glutamate receptors after transient cerebral ischaemia. I: NeuroReport. 1994 ; Bind 5, Nr. 5. s. 593-596.

Bibtex

@article{f14573e074cd11dbbee902004c4f4f50,
title = "Changes in mRNA for metabotropic glutamate receptors after transient cerebral ischaemia",
abstract = "Using a rat 4-vessel occlusion model of cerebral ischaemia we studied the changes in the mRNA level for the metabotropic receptor subtypes mGluR1 alpha, mGluR1 beta, mGluR2, mGluR3, mGluR4, and mGluR5 by means of in situ hybridization with oligonucleotides. After 24 hours of reperfusion the mRNA levels were significantly increased for mGluR2 and mGluR4 while it was significantly decreased for mGluR5. These results suggest that vulnerable neurones react to an increased extracellular glutamate concentration by differential regulation of the mRNA for metabotropic glutamate receptor subtypes which perhaps reflects the different pre- or postsynaptic location and different involvement in ischaemic neurodegeneration.",
keywords = "Animals, Gene Expression Regulation, In Situ Hybridization, Ischemic Attack, Transient, Male, Nerve Tissue Proteins, RNA, Messenger, Rats, Rats, Wistar, Receptors, Glutamate",
author = "D Rosdahl and Seitzberg, {D A} and Thomas Christensen and T Balchen and Diemer, {Nils Henrik}",
year = "1994",
language = "English",
volume = "5",
pages = "593--596",
journal = "NeuroReport",
issn = "0959-4965",
publisher = "Lippincott Williams & Wilkins",
number = "5",

}

RIS

TY - JOUR

T1 - Changes in mRNA for metabotropic glutamate receptors after transient cerebral ischaemia

AU - Rosdahl, D

AU - Seitzberg, D A

AU - Christensen, Thomas

AU - Balchen, T

AU - Diemer, Nils Henrik

PY - 1994

Y1 - 1994

N2 - Using a rat 4-vessel occlusion model of cerebral ischaemia we studied the changes in the mRNA level for the metabotropic receptor subtypes mGluR1 alpha, mGluR1 beta, mGluR2, mGluR3, mGluR4, and mGluR5 by means of in situ hybridization with oligonucleotides. After 24 hours of reperfusion the mRNA levels were significantly increased for mGluR2 and mGluR4 while it was significantly decreased for mGluR5. These results suggest that vulnerable neurones react to an increased extracellular glutamate concentration by differential regulation of the mRNA for metabotropic glutamate receptor subtypes which perhaps reflects the different pre- or postsynaptic location and different involvement in ischaemic neurodegeneration.

AB - Using a rat 4-vessel occlusion model of cerebral ischaemia we studied the changes in the mRNA level for the metabotropic receptor subtypes mGluR1 alpha, mGluR1 beta, mGluR2, mGluR3, mGluR4, and mGluR5 by means of in situ hybridization with oligonucleotides. After 24 hours of reperfusion the mRNA levels were significantly increased for mGluR2 and mGluR4 while it was significantly decreased for mGluR5. These results suggest that vulnerable neurones react to an increased extracellular glutamate concentration by differential regulation of the mRNA for metabotropic glutamate receptor subtypes which perhaps reflects the different pre- or postsynaptic location and different involvement in ischaemic neurodegeneration.

KW - Animals

KW - Gene Expression Regulation

KW - In Situ Hybridization

KW - Ischemic Attack, Transient

KW - Male

KW - Nerve Tissue Proteins

KW - RNA, Messenger

KW - Rats

KW - Rats, Wistar

KW - Receptors, Glutamate

M3 - Journal article

C2 - 8025251

VL - 5

SP - 593

EP - 596

JO - NeuroReport

JF - NeuroReport

SN - 0959-4965

IS - 5

ER -

ID: 255192