Change in HbA1c concentration as decision parameter for frequency of HbA1c measurement
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Hemoglobin A1c (HbA1c) is a long-term measure for glucose concentration in plasma. Since its introduction as a diabetes monitoring tool, and its more recent application as a diagnostic tool, the number of measurements of HbA1c have risen dramatically. However, HbA1c change is slow, so repeating measurements should not be done too often. We use a large, unfiltered dataset from 52,017 patients to determine the possible rate of change in HbA1c concentration. In our laboratory, the critical difference between HbA1c measurements is 8.5%. Our data show that a 1-unit HbA1c rise takes 4 weeks to occur, hence, at a HbA1c concentration around 50 mmol/mol Hgb, a critically increased HbA1c concentration cannot be determined until after 16 weeks. Conversely a critically lower HbA1c can manifest itself after 2 weeks, but after 7 weeks the dropping tendency stops. The amount of measurements that can be cancelled because they were taken sooner than 16 weeks is 23 percent.
Originalsprog | Engelsk |
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Tidsskrift | Scandinavian Journal of Clinical & Laboratory Investigation |
Vol/bind | 79 |
Udgave nummer | 5 |
Sider (fra-til) | 320-324 |
Antal sider | 5 |
ISSN | 0036-5513 |
DOI | |
Status | Udgivet - sep. 2019 |
ID: 232909506