C-di-GMP regulates Pseudomonas aeruginosa stress response to tellurite during both planktonic and biofilm modes of growth

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Standard

C-di-GMP regulates Pseudomonas aeruginosa stress response to tellurite during both planktonic and biofilm modes of growth. / Chua, Song Lin; Sivakumar, Krishnakumar; Rybtke, Morten Levin; Yuan, Mingjun; Andersen, Jens Bo; Nielsen, Thomas E.; Givskov, Michael; Tolker-Nielsen, Tim; Cao, Bin; Kjelleberg, Staffan; Yang, Liang.

I: Scientific Reports, Bind 5, 10052, 2015.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Chua, SL, Sivakumar, K, Rybtke, ML, Yuan, M, Andersen, JB, Nielsen, TE, Givskov, M, Tolker-Nielsen, T, Cao, B, Kjelleberg, S & Yang, L 2015, 'C-di-GMP regulates Pseudomonas aeruginosa stress response to tellurite during both planktonic and biofilm modes of growth', Scientific Reports, bind 5, 10052. https://doi.org/10.1038/srep10052

APA

Chua, S. L., Sivakumar, K., Rybtke, M. L., Yuan, M., Andersen, J. B., Nielsen, T. E., Givskov, M., Tolker-Nielsen, T., Cao, B., Kjelleberg, S., & Yang, L. (2015). C-di-GMP regulates Pseudomonas aeruginosa stress response to tellurite during both planktonic and biofilm modes of growth. Scientific Reports, 5, [10052]. https://doi.org/10.1038/srep10052

Vancouver

Chua SL, Sivakumar K, Rybtke ML, Yuan M, Andersen JB, Nielsen TE o.a. C-di-GMP regulates Pseudomonas aeruginosa stress response to tellurite during both planktonic and biofilm modes of growth. Scientific Reports. 2015;5. 10052. https://doi.org/10.1038/srep10052

Author

Chua, Song Lin ; Sivakumar, Krishnakumar ; Rybtke, Morten Levin ; Yuan, Mingjun ; Andersen, Jens Bo ; Nielsen, Thomas E. ; Givskov, Michael ; Tolker-Nielsen, Tim ; Cao, Bin ; Kjelleberg, Staffan ; Yang, Liang. / C-di-GMP regulates Pseudomonas aeruginosa stress response to tellurite during both planktonic and biofilm modes of growth. I: Scientific Reports. 2015 ; Bind 5.

Bibtex

@article{a4dd113cb2d541ab92220a0e01eae9af,
title = "C-di-GMP regulates Pseudomonas aeruginosa stress response to tellurite during both planktonic and biofilm modes of growth",
abstract = "Stress response plays an important role on microbial adaptation under hostile environmental conditions. It is generally unclear how the signaling transduction pathway mediates a stress response in planktonic and biofilm modes of microbial communities simultaneously. Here, we showed that metalloid tellurite (TeO3(2-)) exposure induced the intracellular content of the secondary messenger cyclic di-GMP (c-di-GMP) of Pseudomonas aeruginosa. Two diguanylate cyclases (DGCs), SadC and SiaD, were responsible for the increased intracellular content of c-di-GMP. Enhanced c-di-GMP levels by TeO3(2-) further increased P. aeruginosa biofilm formation and resistance to TeO3(2-). P. aeruginosa ΔsadCΔsiaD and PAO1/p(lac)-yhjH mutants with low intracellular c-di-GMP content were more sensitive to TeO3(2-) exposure and had low relative fitness compared to the wild-type PAO1 planktonic and biofilm cultures exposed to TeO3(2-). Our study provided evidence that c-di-GMP level can play an important role in mediating stress response in microbial communities during both planktonic and biofilm modes of growth.",
author = "Chua, {Song Lin} and Krishnakumar Sivakumar and Rybtke, {Morten Levin} and Mingjun Yuan and Andersen, {Jens Bo} and Nielsen, {Thomas E.} and Michael Givskov and Tim Tolker-Nielsen and Bin Cao and Staffan Kjelleberg and Liang Yang",
year = "2015",
doi = "10.1038/srep10052",
language = "English",
volume = "5",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "nature publishing group",

}

RIS

TY - JOUR

T1 - C-di-GMP regulates Pseudomonas aeruginosa stress response to tellurite during both planktonic and biofilm modes of growth

AU - Chua, Song Lin

AU - Sivakumar, Krishnakumar

AU - Rybtke, Morten Levin

AU - Yuan, Mingjun

AU - Andersen, Jens Bo

AU - Nielsen, Thomas E.

AU - Givskov, Michael

AU - Tolker-Nielsen, Tim

AU - Cao, Bin

AU - Kjelleberg, Staffan

AU - Yang, Liang

PY - 2015

Y1 - 2015

N2 - Stress response plays an important role on microbial adaptation under hostile environmental conditions. It is generally unclear how the signaling transduction pathway mediates a stress response in planktonic and biofilm modes of microbial communities simultaneously. Here, we showed that metalloid tellurite (TeO3(2-)) exposure induced the intracellular content of the secondary messenger cyclic di-GMP (c-di-GMP) of Pseudomonas aeruginosa. Two diguanylate cyclases (DGCs), SadC and SiaD, were responsible for the increased intracellular content of c-di-GMP. Enhanced c-di-GMP levels by TeO3(2-) further increased P. aeruginosa biofilm formation and resistance to TeO3(2-). P. aeruginosa ΔsadCΔsiaD and PAO1/p(lac)-yhjH mutants with low intracellular c-di-GMP content were more sensitive to TeO3(2-) exposure and had low relative fitness compared to the wild-type PAO1 planktonic and biofilm cultures exposed to TeO3(2-). Our study provided evidence that c-di-GMP level can play an important role in mediating stress response in microbial communities during both planktonic and biofilm modes of growth.

AB - Stress response plays an important role on microbial adaptation under hostile environmental conditions. It is generally unclear how the signaling transduction pathway mediates a stress response in planktonic and biofilm modes of microbial communities simultaneously. Here, we showed that metalloid tellurite (TeO3(2-)) exposure induced the intracellular content of the secondary messenger cyclic di-GMP (c-di-GMP) of Pseudomonas aeruginosa. Two diguanylate cyclases (DGCs), SadC and SiaD, were responsible for the increased intracellular content of c-di-GMP. Enhanced c-di-GMP levels by TeO3(2-) further increased P. aeruginosa biofilm formation and resistance to TeO3(2-). P. aeruginosa ΔsadCΔsiaD and PAO1/p(lac)-yhjH mutants with low intracellular c-di-GMP content were more sensitive to TeO3(2-) exposure and had low relative fitness compared to the wild-type PAO1 planktonic and biofilm cultures exposed to TeO3(2-). Our study provided evidence that c-di-GMP level can play an important role in mediating stress response in microbial communities during both planktonic and biofilm modes of growth.

U2 - 10.1038/srep10052

DO - 10.1038/srep10052

M3 - Journal article

C2 - 25992876

VL - 5

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

M1 - 10052

ER -

ID: 152934693