Carbon monoxide in chronic uraemia related to erythropoietin treatment and smoking habits
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Carbon monoxide in chronic uraemia related to erythropoietin treatment and smoking habits. / Thunedborg, P; Nielsen, A L; Brinkenfeldt, H; Brahm, J; Jensen, H A.
I: Scandinavian Journal of Urology and Nephrology, Bind 29, Nr. 1, 03.1995, s. 21-5.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning
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TY - JOUR
T1 - Carbon monoxide in chronic uraemia related to erythropoietin treatment and smoking habits
AU - Thunedborg, P
AU - Nielsen, A L
AU - Brinkenfeldt, H
AU - Brahm, J
AU - Jensen, H A
PY - 1995/3
Y1 - 1995/3
N2 - In 69 patients on chronic haemodialysis, blood sampled randomly during dialysis was analyzed for carboxyhaemoglobin (COHb). The median value was 1.40% (range 0.9-2.3) in non-smoking patients and (1.4-7.5) in smokers. In non-smokers treated with erythropoietin (EPO) correlation was found between COHb and the weekly EPO dose (r = 0.57, p = 0.007). In smoking patients not given EPO, the COHb correlated well with the number of cigarettes smoked (r = 0.84, p = 0.003). The COHb values did not correlate to the haemoglobin values. It is concluded that COHb levels in uraemic non-smokers are elevated because of increased endogenous CO production from the enhanced erythrocyte turnover. As even low COHb levels may negatively influence the oxygen status of the uraemic patient, the addition of exogenous CO from cigarette smoking should be avoided.
AB - In 69 patients on chronic haemodialysis, blood sampled randomly during dialysis was analyzed for carboxyhaemoglobin (COHb). The median value was 1.40% (range 0.9-2.3) in non-smoking patients and (1.4-7.5) in smokers. In non-smokers treated with erythropoietin (EPO) correlation was found between COHb and the weekly EPO dose (r = 0.57, p = 0.007). In smoking patients not given EPO, the COHb correlated well with the number of cigarettes smoked (r = 0.84, p = 0.003). The COHb values did not correlate to the haemoglobin values. It is concluded that COHb levels in uraemic non-smokers are elevated because of increased endogenous CO production from the enhanced erythrocyte turnover. As even low COHb levels may negatively influence the oxygen status of the uraemic patient, the addition of exogenous CO from cigarette smoking should be avoided.
KW - Adult
KW - Aged
KW - Carbon Monoxide
KW - Chronic Disease
KW - Erythropoietin
KW - Female
KW - Humans
KW - Longitudinal Studies
KW - Male
KW - Middle Aged
KW - Renal Dialysis
KW - Smoking
KW - Uremia
M3 - Journal article
C2 - 7618046
VL - 29
SP - 21
EP - 25
JO - Scandinavian Journal of Urology
JF - Scandinavian Journal of Urology
SN - 2168-1805
IS - 1
ER -
ID: 94519019