Breeze 2.0: an interactive web-tool for visual analysis and comparison of drug response data
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Forlagets udgivne version, 572 KB, PDF-dokument
Functional precision medicine (fPM) offers an exciting, simplified approach to finding the right applications for existing molecules and enhancing therapeutic potential. Integrative and robust tools ensuring high accuracy and reliability of the results are critical. In response to this need, we previously developed Breeze, a drug screening data analysis pipeline, designed to facilitate quality control, dose-response curve fitting, and data visualization in a user-friendly manner. Here, we describe the latest version of Breeze (release 2.0), which implements an array of advanced data exploration capabilities, providing users with comprehensive post-analysis and interactive visualization options that are essential for minimizing false positive/negative outcomes and ensuring accurate interpretation of drug sensitivity and resistance data. The Breeze 2.0 web-tool also enables integrative analysis and cross-comparison of user-uploaded data with publicly available drug response datasets. The updated version incorporates new drug quantification metrics, supports analysis of both multi-dose and single-dose drug screening data and introduces a redesigned, intuitive user interface. With these enhancements, Breeze 2.0 is anticipated to substantially broaden its potential applications in diverse domains of fPM.
|Tidsskrift||Nucleic Acids Research|
|Status||Udgivet - 2023|
FIMM HTB unit is supported by the University of Helsinki and Biocenter Finland; T.A., B.S.L. and P.Ö. were supported by the European Union's Horizon Europe Research & Innovation Programme [REMEDi4ALL project, 101057442]; T.A. by European Union's Horizon 2020 Research and Innovation Programme (ERA PerMed JAKSTAT-TARGET and CLL-CLUE projects), and Academy of Finland [326238, 340141, 344698, 345803]; P.Ö., B.S.L. were supported by Knut and Alice Wallenberg Foundation [KAW 2020.0241, V-2020-0699, KAW 2020-0182]; O.K. was supported by (2015.0291). The Finnish Unix User Group Foundation (FUUG.fi) (to S.P., F.I., A.I., J.S.). Funding for open access charge: Finnish Unix User Group (FUUG.fi).
© 2023 The Author(s). Published by Oxford University Press on behalf of Nucleic Acids Research.