Brain energetics during the sleep-wake cycle

Forskning

Brain energetics during the sleep-wake cycle

Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt

Standard

Brain energetics during the sleep-wake cycle. / DiNuzzo, Mauro; Nedergaard, Maiken.

I: Current Opinion in Neurobiology, Bind 47, 12.2017, s. 65-72.

Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt

Harvard

DiNuzzo, M & Nedergaard, M 2017, 'Brain energetics during the sleep-wake cycle', Current Opinion in Neurobiology, bind 47, s. 65-72. https://doi.org/10.1016/j.conb.2017.09.010

APA

DiNuzzo, M., & Nedergaard, M. (2017). Brain energetics during the sleep-wake cycle. Current Opinion in Neurobiology, 47, 65-72. https://doi.org/10.1016/j.conb.2017.09.010

Vancouver

DiNuzzo M, Nedergaard M. Brain energetics during the sleep-wake cycle. Current Opinion in Neurobiology. 2017 dec.;47:65-72. https://doi.org/10.1016/j.conb.2017.09.010

Author

DiNuzzo, Mauro ; Nedergaard, Maiken. / Brain energetics during the sleep-wake cycle. I: Current Opinion in Neurobiology. 2017 ; Bind 47. s. 65-72.

Bibtex

@article{826e93e90f714c3a9e5060dd6e75f7dc,

title = "Brain energetics during the sleep-wake cycle",

abstract = "Brain activity during wakefulness is associated with high metabolic rates that are believed to support information processing and memory encoding. In spite of loss of consciousness, sleep still carries a substantial energy cost. Experimental evidence supports a cerebral metabolic shift taking place during sleep that suppresses aerobic glycolysis, a hallmark of environment-oriented waking behavior and synaptic plasticity. Recent studies reveal that glial astrocytes respond to the reduction of wake-promoting neuromodulators by regulating volume, composition and glymphatic drainage of interstitial fluid. These events are accompanied by changes in neuronal discharge patterns, astrocyte-neuron interactions, synaptic transactions and underlying metabolic features. Internally-generated neuronal activity and network homeostasis are proposed to account for the high sleep-related energy demand.",

keywords = "Journal Article, Review",

author = "Mauro DiNuzzo and Maiken Nedergaard",

year = "2017",

month = dec,

doi = "10.1016/j.conb.2017.09.010",

language = "English",

volume = "47",

pages = "65--72",

journal = "Current Opinion in Neurobiology",

issn = "0959-4388",

publisher = "Elsevier Ltd. * Current Opinion Journals",

}

RIS

TY - JOUR

T1 - Brain energetics during the sleep-wake cycle

AU - DiNuzzo, Mauro

AU - Nedergaard, Maiken

PY - 2017/12

Y1 - 2017/12

N2 - Brain activity during wakefulness is associated with high metabolic rates that are believed to support information processing and memory encoding. In spite of loss of consciousness, sleep still carries a substantial energy cost. Experimental evidence supports a cerebral metabolic shift taking place during sleep that suppresses aerobic glycolysis, a hallmark of environment-oriented waking behavior and synaptic plasticity. Recent studies reveal that glial astrocytes respond to the reduction of wake-promoting neuromodulators by regulating volume, composition and glymphatic drainage of interstitial fluid. These events are accompanied by changes in neuronal discharge patterns, astrocyte-neuron interactions, synaptic transactions and underlying metabolic features. Internally-generated neuronal activity and network homeostasis are proposed to account for the high sleep-related energy demand.

AB - Brain activity during wakefulness is associated with high metabolic rates that are believed to support information processing and memory encoding. In spite of loss of consciousness, sleep still carries a substantial energy cost. Experimental evidence supports a cerebral metabolic shift taking place during sleep that suppresses aerobic glycolysis, a hallmark of environment-oriented waking behavior and synaptic plasticity. Recent studies reveal that glial astrocytes respond to the reduction of wake-promoting neuromodulators by regulating volume, composition and glymphatic drainage of interstitial fluid. These events are accompanied by changes in neuronal discharge patterns, astrocyte-neuron interactions, synaptic transactions and underlying metabolic features. Internally-generated neuronal activity and network homeostasis are proposed to account for the high sleep-related energy demand.

KW - Journal Article

KW - Review

U2 - 10.1016/j.conb.2017.09.010

DO - 10.1016/j.conb.2017.09.010

M3 - Review

C2 - 29024871

VL - 47

SP - 65

EP - 72

JO - Current Opinion in Neurobiology

JF - Current Opinion in Neurobiology

SN - 0959-4388

ER -

ID: 185945191