Biomarkers in patients with Takotsubo cardiomyopathy compared to patients with acute anterior ST-elevation myocardial infarction

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Biomarkers in patients with Takotsubo cardiomyopathy compared to patients with acute anterior ST-elevation myocardial infarction. / Højagergaard, Mathias Alexander; Hassager, Christian; Christensen, Thomas Emil; Bang, Lia Evi; Gøtze, Jens Peter; Ostrowski, Sisse Rye; Holmvang, Lene; Frydland, Martin.

I: Biomarkers, Bind 25, Nr. 2, 03.2020, s. 137-143.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Højagergaard, MA, Hassager, C, Christensen, TE, Bang, LE, Gøtze, JP, Ostrowski, SR, Holmvang, L & Frydland, M 2020, 'Biomarkers in patients with Takotsubo cardiomyopathy compared to patients with acute anterior ST-elevation myocardial infarction', Biomarkers, bind 25, nr. 2, s. 137-143. https://doi.org/10.1080/1354750X.2019.1710767

APA

Højagergaard, M. A., Hassager, C., Christensen, T. E., Bang, L. E., Gøtze, J. P., Ostrowski, S. R., Holmvang, L., & Frydland, M. (2020). Biomarkers in patients with Takotsubo cardiomyopathy compared to patients with acute anterior ST-elevation myocardial infarction. Biomarkers, 25(2), 137-143. https://doi.org/10.1080/1354750X.2019.1710767

Vancouver

Højagergaard MA, Hassager C, Christensen TE, Bang LE, Gøtze JP, Ostrowski SR o.a. Biomarkers in patients with Takotsubo cardiomyopathy compared to patients with acute anterior ST-elevation myocardial infarction. Biomarkers. 2020 mar;25(2):137-143. https://doi.org/10.1080/1354750X.2019.1710767

Author

Højagergaard, Mathias Alexander ; Hassager, Christian ; Christensen, Thomas Emil ; Bang, Lia Evi ; Gøtze, Jens Peter ; Ostrowski, Sisse Rye ; Holmvang, Lene ; Frydland, Martin. / Biomarkers in patients with Takotsubo cardiomyopathy compared to patients with acute anterior ST-elevation myocardial infarction. I: Biomarkers. 2020 ; Bind 25, Nr. 2. s. 137-143.

Bibtex

@article{03f10748584746368d10dad2547f86b7,
title = "Biomarkers in patients with Takotsubo cardiomyopathy compared to patients with acute anterior ST-elevation myocardial infarction",
abstract = "Background: Takotsubo cardiomyopathy (TTC) is a syndrome of acute non-coronary heart failure with similar symptoms and electrocardiograms to acute anterior ST-elevation myocardial infarction (STEMI). Little is known about the pathophysiology of TTC. We assessed admission plasma concentrations of biomarkers reflecting neuroendocrine response (copeptin, mid-regional-pro-adrenomedullin, pro-atrial-natriuretic-peptide, soluble thrombomodulin (sTM), syndecan-1) and inflammation (suppression-of-tumorigenicity 2 (ST2), high-sensitive C-reactive-protein) in TTC patients and compared to patients with acute anterior STEMI.Materials and methods: Twenty TTC patients were matched with 40 STEMI patients by age, gender and left ventricular ejection fraction. Blood was sampled upon hospital admission immediately before acute coronary angiography.Results: The groups had similar comorbidities. TTC patients had higher plasma concentrations of sTM: 7.94 (5.89;9.61) vs. 6.42 (5.50;7.82)ng/ml, p = 0.04 and ST2 (53 (32;157) vs. 45 (31;55)ng/ml, p = 0.008) and higher heart rate: 101 ([Formula: see text]33) vs. 76([Formula: see text]14)bpm, p = 0.0001, but lower concentrations of copeptin (10.4 (7.6;39) vs. 92.3 (13;197)pmol/l, p < 0.05) and troponin T (348 (98;759) vs. 1190 (261;4105)ng/l, p = 0.04).Conclusion: TTC patients had higher plasma concentrations of sTM and ST2, higher heart rate and lower copeptin and troponin T concentrations compared to acute anterior STEMI patients. This study contributes to the hypothesis that TTC patients have endothelial cell damage and are hemodynamically more stable than patients with acute anterior STEMI on admission.",
keywords = "Aged, Biomarkers/blood, Diagnosis, Differential, Endothelial Cells/pathology, Female, Glycopeptides/blood, Heart Rate, Hemodynamics, Humans, Interleukin-1 Receptor-Like 1 Protein/blood, Male, Middle Aged, ST Elevation Myocardial Infarction/blood, Takotsubo Cardiomyopathy/blood, Thrombomodulin/blood, Troponin T/blood",
author = "H{\o}jagergaard, {Mathias Alexander} and Christian Hassager and Christensen, {Thomas Emil} and Bang, {Lia Evi} and G{\o}tze, {Jens Peter} and Ostrowski, {Sisse Rye} and Lene Holmvang and Martin Frydland",
year = "2020",
month = mar,
doi = "10.1080/1354750X.2019.1710767",
language = "English",
volume = "25",
pages = "137--143",
journal = "Biomarkers",
issn = "1354-750X",
publisher = "Taylor & Francis",
number = "2",

}

RIS

TY - JOUR

T1 - Biomarkers in patients with Takotsubo cardiomyopathy compared to patients with acute anterior ST-elevation myocardial infarction

AU - Højagergaard, Mathias Alexander

AU - Hassager, Christian

AU - Christensen, Thomas Emil

AU - Bang, Lia Evi

AU - Gøtze, Jens Peter

AU - Ostrowski, Sisse Rye

AU - Holmvang, Lene

AU - Frydland, Martin

PY - 2020/3

Y1 - 2020/3

N2 - Background: Takotsubo cardiomyopathy (TTC) is a syndrome of acute non-coronary heart failure with similar symptoms and electrocardiograms to acute anterior ST-elevation myocardial infarction (STEMI). Little is known about the pathophysiology of TTC. We assessed admission plasma concentrations of biomarkers reflecting neuroendocrine response (copeptin, mid-regional-pro-adrenomedullin, pro-atrial-natriuretic-peptide, soluble thrombomodulin (sTM), syndecan-1) and inflammation (suppression-of-tumorigenicity 2 (ST2), high-sensitive C-reactive-protein) in TTC patients and compared to patients with acute anterior STEMI.Materials and methods: Twenty TTC patients were matched with 40 STEMI patients by age, gender and left ventricular ejection fraction. Blood was sampled upon hospital admission immediately before acute coronary angiography.Results: The groups had similar comorbidities. TTC patients had higher plasma concentrations of sTM: 7.94 (5.89;9.61) vs. 6.42 (5.50;7.82)ng/ml, p = 0.04 and ST2 (53 (32;157) vs. 45 (31;55)ng/ml, p = 0.008) and higher heart rate: 101 ([Formula: see text]33) vs. 76([Formula: see text]14)bpm, p = 0.0001, but lower concentrations of copeptin (10.4 (7.6;39) vs. 92.3 (13;197)pmol/l, p < 0.05) and troponin T (348 (98;759) vs. 1190 (261;4105)ng/l, p = 0.04).Conclusion: TTC patients had higher plasma concentrations of sTM and ST2, higher heart rate and lower copeptin and troponin T concentrations compared to acute anterior STEMI patients. This study contributes to the hypothesis that TTC patients have endothelial cell damage and are hemodynamically more stable than patients with acute anterior STEMI on admission.

AB - Background: Takotsubo cardiomyopathy (TTC) is a syndrome of acute non-coronary heart failure with similar symptoms and electrocardiograms to acute anterior ST-elevation myocardial infarction (STEMI). Little is known about the pathophysiology of TTC. We assessed admission plasma concentrations of biomarkers reflecting neuroendocrine response (copeptin, mid-regional-pro-adrenomedullin, pro-atrial-natriuretic-peptide, soluble thrombomodulin (sTM), syndecan-1) and inflammation (suppression-of-tumorigenicity 2 (ST2), high-sensitive C-reactive-protein) in TTC patients and compared to patients with acute anterior STEMI.Materials and methods: Twenty TTC patients were matched with 40 STEMI patients by age, gender and left ventricular ejection fraction. Blood was sampled upon hospital admission immediately before acute coronary angiography.Results: The groups had similar comorbidities. TTC patients had higher plasma concentrations of sTM: 7.94 (5.89;9.61) vs. 6.42 (5.50;7.82)ng/ml, p = 0.04 and ST2 (53 (32;157) vs. 45 (31;55)ng/ml, p = 0.008) and higher heart rate: 101 ([Formula: see text]33) vs. 76([Formula: see text]14)bpm, p = 0.0001, but lower concentrations of copeptin (10.4 (7.6;39) vs. 92.3 (13;197)pmol/l, p < 0.05) and troponin T (348 (98;759) vs. 1190 (261;4105)ng/l, p = 0.04).Conclusion: TTC patients had higher plasma concentrations of sTM and ST2, higher heart rate and lower copeptin and troponin T concentrations compared to acute anterior STEMI patients. This study contributes to the hypothesis that TTC patients have endothelial cell damage and are hemodynamically more stable than patients with acute anterior STEMI on admission.

KW - Aged

KW - Biomarkers/blood

KW - Diagnosis, Differential

KW - Endothelial Cells/pathology

KW - Female

KW - Glycopeptides/blood

KW - Heart Rate

KW - Hemodynamics

KW - Humans

KW - Interleukin-1 Receptor-Like 1 Protein/blood

KW - Male

KW - Middle Aged

KW - ST Elevation Myocardial Infarction/blood

KW - Takotsubo Cardiomyopathy/blood

KW - Thrombomodulin/blood

KW - Troponin T/blood

U2 - 10.1080/1354750X.2019.1710767

DO - 10.1080/1354750X.2019.1710767

M3 - Journal article

C2 - 31902247

VL - 25

SP - 137

EP - 143

JO - Biomarkers

JF - Biomarkers

SN - 1354-750X

IS - 2

ER -

ID: 250817136