Beat-to-beat variability of QT intervals is increased in patients with drug-induced long-QT syndrome: a case control pilot study
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Beat-to-beat variability of QT intervals is increased in patients with drug-induced long-QT syndrome : a case control pilot study. / Hinterseer, Martin; Thomsen, Morten Bækgaard; Beckmann, Britt-Maria; Pfeufer, Arne; Schimpf, Rainer; Wichmann, H-Erich; Steinbeck, Gerhard; Vos, Marc A; Kaab, Stefan.
I: European Heart Journal, Bind 29, Nr. 2, 01.2008, s. 185-90.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Beat-to-beat variability of QT intervals is increased in patients with drug-induced long-QT syndrome
T2 - a case control pilot study
AU - Hinterseer, Martin
AU - Thomsen, Morten Bækgaard
AU - Beckmann, Britt-Maria
AU - Pfeufer, Arne
AU - Schimpf, Rainer
AU - Wichmann, H-Erich
AU - Steinbeck, Gerhard
AU - Vos, Marc A
AU - Kaab, Stefan
PY - 2008/1
Y1 - 2008/1
N2 - Torsades de pointes arrhythmias (TdP) occur by definition in the setting of prolonged QT intervals. Animal models of drug induced Long-QT syndrome (dLQTS) have shown higher predictive value for proarrhythmia with beat-to-beat variability of repolarization duration (BVR) when compared with QT intervals. Here, we evaluate variability of QT intervals in patients with a history of drug-induced long QT syndrome (dLQTS) and TdP in absence of a mutation in any of the major LQTS genes.
AB - Torsades de pointes arrhythmias (TdP) occur by definition in the setting of prolonged QT intervals. Animal models of drug induced Long-QT syndrome (dLQTS) have shown higher predictive value for proarrhythmia with beat-to-beat variability of repolarization duration (BVR) when compared with QT intervals. Here, we evaluate variability of QT intervals in patients with a history of drug-induced long QT syndrome (dLQTS) and TdP in absence of a mutation in any of the major LQTS genes.
KW - Aged
KW - Arrhythmias, Cardiac
KW - Case-Control Studies
KW - Disease Susceptibility
KW - Electrocardiography
KW - Female
KW - Heart Rate
KW - Humans
KW - Long QT Syndrome
KW - Male
KW - Middle Aged
KW - Pilot Projects
KW - Predictive Value of Tests
KW - Torsades de Pointes
U2 - 10.1093/eurheartj/ehm586
DO - 10.1093/eurheartj/ehm586
M3 - Journal article
C2 - 18156612
VL - 29
SP - 185
EP - 190
JO - European Heart Journal
JF - European Heart Journal
SN - 0195-668X
IS - 2
ER -
ID: 45965394