Association of serum 25-hydroxyvitamin D levels with markers for metabolic syndrome in the elderly: a repeated measure analysis

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Standard

Association of serum 25-hydroxyvitamin D levels with markers for metabolic syndrome in the elderly : a repeated measure analysis. / Park, Hye Yin; Lim, Youn-Hee; Kim, Jin Hee; Bae, Sanghyuk; Oh, Se-Young; Hong, Yun-Chul.

I: Journal of Korean Medical Science, Bind 27, Nr. 6, 2012, s. 653-660.

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Harvard

Park, HY, Lim, Y-H, Kim, JH, Bae, S, Oh, S-Y & Hong, Y-C 2012, 'Association of serum 25-hydroxyvitamin D levels with markers for metabolic syndrome in the elderly: a repeated measure analysis', Journal of Korean Medical Science, bind 27, nr. 6, s. 653-660. https://doi.org/10.3346/jkms.2012.27.6.653

APA

Park, H. Y., Lim, Y-H., Kim, J. H., Bae, S., Oh, S-Y., & Hong, Y-C. (2012). Association of serum 25-hydroxyvitamin D levels with markers for metabolic syndrome in the elderly: a repeated measure analysis. Journal of Korean Medical Science, 27(6), 653-660. https://doi.org/10.3346/jkms.2012.27.6.653

Vancouver

Park HY, Lim Y-H, Kim JH, Bae S, Oh S-Y, Hong Y-C. Association of serum 25-hydroxyvitamin D levels with markers for metabolic syndrome in the elderly: a repeated measure analysis. Journal of Korean Medical Science. 2012;27(6):653-660. https://doi.org/10.3346/jkms.2012.27.6.653

Author

Park, Hye Yin ; Lim, Youn-Hee ; Kim, Jin Hee ; Bae, Sanghyuk ; Oh, Se-Young ; Hong, Yun-Chul. / Association of serum 25-hydroxyvitamin D levels with markers for metabolic syndrome in the elderly : a repeated measure analysis. I: Journal of Korean Medical Science. 2012 ; Bind 27, Nr. 6. s. 653-660.

Bibtex

@article{b2c54161e84a4f2fa81a46be60e201ab,
title = "Association of serum 25-hydroxyvitamin D levels with markers for metabolic syndrome in the elderly: a repeated measure analysis",
abstract = "The purpose of current study was to investigate associations of serum 25-hydroxyvitamin D (OHVD) levels with markers for metabolic syndrome in elderly Koreans. We conducted a panel study on 301 individuals over 60 yr old in Seoul, Korea, and repeatedly measured serum OHVD, glucose, insulin, and lipid levels. Mixed effect model and generalized estimating equations were used to investigate relationships between serum OHVD levels with marker levels for metabolic syndrome and each of its categories. Of all subjects, 76.6% were vitamin D deficient (< 50 nM) and 16.9% were insufficient (< 75 nM). Inverse association was demonstrated between serum OHVD levels and insulin (P = 0.004), triglyceride (P = 0.023) and blood pressure (systolic blood pressure: P = 0.002; diastolic blood pressure: P < 0.001). Vitamin D deficiency was found to increase risk of 'hypertriglyceridemia' category of metabolic syndrome (odds ratio: 1.73, 95% confidence interval: 1.13-2.66). In conclusion, we found from our repeated measure analysis that decreasing serum OHVD levels are associated with increasing insulin resistance, increasing serum triglyceride levels and increasing blood pressure in elderly Koreans, and confirmed on the risk of 'hypertriglyceridemia' in vitamin D deficient subjects.",
keywords = "Aged, Aged, 80 and over, Biomarkers/blood, Blood Pressure, Female, Humans, Hypertriglyceridemia/diagnosis, Insulin/blood, Insulin Resistance, Male, Metabolic Syndrome/diagnosis, Middle Aged, Odds Ratio, Risk Factors, Triglycerides/blood, Vitamin D/analogs & derivatives, Vitamin D Deficiency/complications",
author = "Park, {Hye Yin} and Youn-Hee Lim and Kim, {Jin Hee} and Sanghyuk Bae and Se-Young Oh and Yun-Chul Hong",
year = "2012",
doi = "10.3346/jkms.2012.27.6.653",
language = "English",
volume = "27",
pages = "653--660",
journal = "Journal of Korean Medical Science",
issn = "1011-8934",
publisher = "Korean Academy of Medical Sciences",
number = "6",

}

RIS

TY - JOUR

T1 - Association of serum 25-hydroxyvitamin D levels with markers for metabolic syndrome in the elderly

T2 - a repeated measure analysis

AU - Park, Hye Yin

AU - Lim, Youn-Hee

AU - Kim, Jin Hee

AU - Bae, Sanghyuk

AU - Oh, Se-Young

AU - Hong, Yun-Chul

PY - 2012

Y1 - 2012

N2 - The purpose of current study was to investigate associations of serum 25-hydroxyvitamin D (OHVD) levels with markers for metabolic syndrome in elderly Koreans. We conducted a panel study on 301 individuals over 60 yr old in Seoul, Korea, and repeatedly measured serum OHVD, glucose, insulin, and lipid levels. Mixed effect model and generalized estimating equations were used to investigate relationships between serum OHVD levels with marker levels for metabolic syndrome and each of its categories. Of all subjects, 76.6% were vitamin D deficient (< 50 nM) and 16.9% were insufficient (< 75 nM). Inverse association was demonstrated between serum OHVD levels and insulin (P = 0.004), triglyceride (P = 0.023) and blood pressure (systolic blood pressure: P = 0.002; diastolic blood pressure: P < 0.001). Vitamin D deficiency was found to increase risk of 'hypertriglyceridemia' category of metabolic syndrome (odds ratio: 1.73, 95% confidence interval: 1.13-2.66). In conclusion, we found from our repeated measure analysis that decreasing serum OHVD levels are associated with increasing insulin resistance, increasing serum triglyceride levels and increasing blood pressure in elderly Koreans, and confirmed on the risk of 'hypertriglyceridemia' in vitamin D deficient subjects.

AB - The purpose of current study was to investigate associations of serum 25-hydroxyvitamin D (OHVD) levels with markers for metabolic syndrome in elderly Koreans. We conducted a panel study on 301 individuals over 60 yr old in Seoul, Korea, and repeatedly measured serum OHVD, glucose, insulin, and lipid levels. Mixed effect model and generalized estimating equations were used to investigate relationships between serum OHVD levels with marker levels for metabolic syndrome and each of its categories. Of all subjects, 76.6% were vitamin D deficient (< 50 nM) and 16.9% were insufficient (< 75 nM). Inverse association was demonstrated between serum OHVD levels and insulin (P = 0.004), triglyceride (P = 0.023) and blood pressure (systolic blood pressure: P = 0.002; diastolic blood pressure: P < 0.001). Vitamin D deficiency was found to increase risk of 'hypertriglyceridemia' category of metabolic syndrome (odds ratio: 1.73, 95% confidence interval: 1.13-2.66). In conclusion, we found from our repeated measure analysis that decreasing serum OHVD levels are associated with increasing insulin resistance, increasing serum triglyceride levels and increasing blood pressure in elderly Koreans, and confirmed on the risk of 'hypertriglyceridemia' in vitamin D deficient subjects.

KW - Aged

KW - Aged, 80 and over

KW - Biomarkers/blood

KW - Blood Pressure

KW - Female

KW - Humans

KW - Hypertriglyceridemia/diagnosis

KW - Insulin/blood

KW - Insulin Resistance

KW - Male

KW - Metabolic Syndrome/diagnosis

KW - Middle Aged

KW - Odds Ratio

KW - Risk Factors

KW - Triglycerides/blood

KW - Vitamin D/analogs & derivatives

KW - Vitamin D Deficiency/complications

U2 - 10.3346/jkms.2012.27.6.653

DO - 10.3346/jkms.2012.27.6.653

M3 - Journal article

C2 - 22690097

VL - 27

SP - 653

EP - 660

JO - Journal of Korean Medical Science

JF - Journal of Korean Medical Science

SN - 1011-8934

IS - 6

ER -

ID: 230071780