Association between selected antimicrobial resistance genes and antimicrobial exposure in Danish pig farms
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Standard
Association between selected antimicrobial resistance genes and antimicrobial exposure in Danish pig farms. / Birkegård, Anna Camilla; Halasa, Tariq; Græsbøll, Kaare; Clasen, Julie; Folkesson, Anders; Toft, Nils.
I: Scientific Reports, Bind 7, Nr. 1, 9683, 29.08.2017.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Association between selected antimicrobial resistance genes and antimicrobial exposure in Danish pig farms
AU - Birkegård, Anna Camilla
AU - Halasa, Tariq
AU - Græsbøll, Kaare
AU - Clasen, Julie
AU - Folkesson, Anders
AU - Toft, Nils
PY - 2017/8/29
Y1 - 2017/8/29
N2 - Bacterial antimicrobial resistance (AMR) in pigs is an important public health concern due to its possible transfer to humans. We aimed at quantifying the relationship between the lifetime exposure of antimicrobials and seven antimicrobial resistance genes in Danish slaughter pig farms. AMR gene levels were quantified by qPCR of total-community DNA in faecal samples obtained from 681 batches of slaughter pigs. The lifetime exposure to antimicrobials was estimated at batch level for the piglet, weaner, and finisher periods individually for the sampled batches. We showed that the effect of antimicrobial exposure on the levels of AMR genes was complex and unique for each individual gene. Several antimicrobial classes had both negative and positive correlations with the AMR genes. From 10-42% of the variation in AMR gene levels could be explained in the final regression models, indicating that antimicrobial exposure is not the only important determinant of the AMR gene levels.
AB - Bacterial antimicrobial resistance (AMR) in pigs is an important public health concern due to its possible transfer to humans. We aimed at quantifying the relationship between the lifetime exposure of antimicrobials and seven antimicrobial resistance genes in Danish slaughter pig farms. AMR gene levels were quantified by qPCR of total-community DNA in faecal samples obtained from 681 batches of slaughter pigs. The lifetime exposure to antimicrobials was estimated at batch level for the piglet, weaner, and finisher periods individually for the sampled batches. We showed that the effect of antimicrobial exposure on the levels of AMR genes was complex and unique for each individual gene. Several antimicrobial classes had both negative and positive correlations with the AMR genes. From 10-42% of the variation in AMR gene levels could be explained in the final regression models, indicating that antimicrobial exposure is not the only important determinant of the AMR gene levels.
U2 - 10.1038/s41598-017-10092-9
DO - 10.1038/s41598-017-10092-9
M3 - Journal article
C2 - 28852034
VL - 7
JO - Scientific Reports
JF - Scientific Reports
SN - 2045-2322
IS - 1
M1 - 9683
ER -
ID: 203330504