Association between Atopic Dermatitis and the Metabolic Syndrome: A Systematic Review
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Association between Atopic Dermatitis and the Metabolic Syndrome : A Systematic Review. / Ali, Zarqa; Ulrik, Charlotte Suppli; Agner, Tove; Thomsen, Simon Francis.
I: Dermatology, Bind 234, Nr. 3-4, 2018, s. 79-85.Publikation: Bidrag til tidsskrift › Review › fagfællebedømt
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TY - JOUR
T1 - Association between Atopic Dermatitis and the Metabolic Syndrome
T2 - A Systematic Review
AU - Ali, Zarqa
AU - Ulrik, Charlotte Suppli
AU - Agner, Tove
AU - Thomsen, Simon Francis
PY - 2018
Y1 - 2018
N2 - Atopic dermatitis (AD) may be associated with the metabolic syndrome and by that carry an increased risk of cardiovascular disease. Our objective was to provide an update on current knowledge of the association between AD and metabolic syndrome, including each component of the metabolic syndrome. A systematic literature review was performed to identify studies investigating the association between metabolic syndrome and AD from PubMed, Embase, and the Cochrane Library in accordance with the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines. A total of 14 studies, investigating the association between AD and the metabolic syndrome or AD and components of metabolic syndrome fulfilled the inclusion criteria and were included. It seems unlikely that the association between AD and metabolic syndrome is causal. However, women with AD tended to have components of metabolic syndrome more often than women without AD. There was a positive association between AD and central obesity measured as waist circumference, and this association was stronger for women than men. Despite conflicting results regarding hypertension, the association between hypertension and AD also appeared stronger for women. On the other hand, the association between AD and hyperglycemia appears unlikely, and the association between AD and cholesterol levels was inconsistent. In conclusion, it remains unclear whether AD is a risk factor for metabolic syndrome and its components. However, data indicate that central obesity is associated with AD and that the association is stronger for women than men. (c) 2018 S. Karger AG, Basel.
AB - Atopic dermatitis (AD) may be associated with the metabolic syndrome and by that carry an increased risk of cardiovascular disease. Our objective was to provide an update on current knowledge of the association between AD and metabolic syndrome, including each component of the metabolic syndrome. A systematic literature review was performed to identify studies investigating the association between metabolic syndrome and AD from PubMed, Embase, and the Cochrane Library in accordance with the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines. A total of 14 studies, investigating the association between AD and the metabolic syndrome or AD and components of metabolic syndrome fulfilled the inclusion criteria and were included. It seems unlikely that the association between AD and metabolic syndrome is causal. However, women with AD tended to have components of metabolic syndrome more often than women without AD. There was a positive association between AD and central obesity measured as waist circumference, and this association was stronger for women than men. Despite conflicting results regarding hypertension, the association between hypertension and AD also appeared stronger for women. On the other hand, the association between AD and hyperglycemia appears unlikely, and the association between AD and cholesterol levels was inconsistent. In conclusion, it remains unclear whether AD is a risk factor for metabolic syndrome and its components. However, data indicate that central obesity is associated with AD and that the association is stronger for women than men. (c) 2018 S. Karger AG, Basel.
KW - Atopic dermatitis
KW - Eczema
KW - Metabolic syndrome
KW - Obesity
KW - Hypertension
KW - Diabetes
KW - Hyperglycemia
KW - Dyslipidemia
U2 - 10.1159/000491593
DO - 10.1159/000491593
M3 - Review
C2 - 30110673
VL - 234
SP - 79
EP - 85
JO - Dermatology
JF - Dermatology
SN - 1018-8665
IS - 3-4
ER -
ID: 212302884