Arresting chromosome replication upon energy starvation in Escherichia coli

Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt

Standard

Arresting chromosome replication upon energy starvation in Escherichia coli. / Charbon, Godefroid; Frimodt-Møller, Jakob; Løbner-Olesen, Anders.

I: Current Genetics, Bind 67, Nr. 6, 2021, s. 877-882.

Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt

Harvard

Charbon, G, Frimodt-Møller, J & Løbner-Olesen, A 2021, 'Arresting chromosome replication upon energy starvation in Escherichia coli', Current Genetics, bind 67, nr. 6, s. 877-882. https://doi.org/10.1007/s00294-021-01202-2

APA

Charbon, G., Frimodt-Møller, J., & Løbner-Olesen, A. (2021). Arresting chromosome replication upon energy starvation in Escherichia coli. Current Genetics, 67(6), 877-882. https://doi.org/10.1007/s00294-021-01202-2

Vancouver

Charbon G, Frimodt-Møller J, Løbner-Olesen A. Arresting chromosome replication upon energy starvation in Escherichia coli. Current Genetics. 2021;67(6):877-882. https://doi.org/10.1007/s00294-021-01202-2

Author

Charbon, Godefroid ; Frimodt-Møller, Jakob ; Løbner-Olesen, Anders. / Arresting chromosome replication upon energy starvation in Escherichia coli. I: Current Genetics. 2021 ; Bind 67, Nr. 6. s. 877-882.

Bibtex

@article{9ce76bf372ca4b14a48f2f69382a406d,

title = "Arresting chromosome replication upon energy starvation in Escherichia coli",

abstract = "Most organisms possess several cell cycle checkpoints to preserve genome stability in periods of stress. Upon starvation, the absence of chromosomal duplication in the bacterium Escherichia coli is ensured by holding off commencement of replication. During normal growth, accumulation of the initiator protein DnaA along with cell cycle changes in its activity, ensure that DNA replication starts only once per cell cycle. Upon nutrient starvation, the prevailing model is that an arrest in DnaA protein synthesis is responsible for the absence of initiation. Recent indications now suggest that DnaA degradation may also play a role. Here we comment on the implications of this potential new layer of regulation.",

keywords = "Cellular Energy Status, Chromosome replication, DnaA, Genome stability, DNAA PROTEIN, INITIATION MASS, ATP HYDROLYSIS, GROWTH, MUTANT, CYCLE, BINDING, DARS2, HDA",

author = "Godefroid Charbon and Jakob Frimodt-M{\o}ller and Anders L{\o}bner-Olesen",

year = "2021",

doi = "10.1007/s00294-021-01202-2",

language = "English",

volume = "67",

pages = "877--882",

journal = "Current Genetics",

issn = "0172-8083",

publisher = "Springer",

number = "6",

}

RIS

TY - JOUR

T1 - Arresting chromosome replication upon energy starvation in Escherichia coli

AU - Charbon, Godefroid

AU - Frimodt-Møller, Jakob

AU - Løbner-Olesen, Anders

PY - 2021

Y1 - 2021

N2 - Most organisms possess several cell cycle checkpoints to preserve genome stability in periods of stress. Upon starvation, the absence of chromosomal duplication in the bacterium Escherichia coli is ensured by holding off commencement of replication. During normal growth, accumulation of the initiator protein DnaA along with cell cycle changes in its activity, ensure that DNA replication starts only once per cell cycle. Upon nutrient starvation, the prevailing model is that an arrest in DnaA protein synthesis is responsible for the absence of initiation. Recent indications now suggest that DnaA degradation may also play a role. Here we comment on the implications of this potential new layer of regulation.

AB - Most organisms possess several cell cycle checkpoints to preserve genome stability in periods of stress. Upon starvation, the absence of chromosomal duplication in the bacterium Escherichia coli is ensured by holding off commencement of replication. During normal growth, accumulation of the initiator protein DnaA along with cell cycle changes in its activity, ensure that DNA replication starts only once per cell cycle. Upon nutrient starvation, the prevailing model is that an arrest in DnaA protein synthesis is responsible for the absence of initiation. Recent indications now suggest that DnaA degradation may also play a role. Here we comment on the implications of this potential new layer of regulation.

KW - Cellular Energy Status

KW - Chromosome replication

KW - DnaA

KW - Genome stability

KW - DNAA PROTEIN

KW - INITIATION MASS

KW - ATP HYDROLYSIS

KW - GROWTH

KW - MUTANT

KW - CYCLE

KW - BINDING

KW - DARS2

KW - HDA

U2 - 10.1007/s00294-021-01202-2

DO - 10.1007/s00294-021-01202-2

M3 - Review

C2 - 34345967

VL - 67

SP - 877

EP - 882

JO - Current Genetics

JF - Current Genetics

SN - 0172-8083

IS - 6

ER -

ID: 275937403