Antibody responses to Rhoptry-Associated Protein-1 (RAP-1) of Plasmodium falciparum parasites in humans from areas of different malaria endemicity
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Antibody responses to Rhoptry-Associated Protein-1 (RAP-1) of Plasmodium falciparum parasites in humans from areas of different malaria endemicity. / Jakobsen, P H; Kurtzhals, J A; Riley, E M; Hviid, L; Theander, T G; Morris-Jones, S; Jensen, J B; Bayoumi, R A; Ridley, R G; Greenwood, B M.
I: Parasite Immunology, Bind 19, Nr. 9, 1997, s. 387-93.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Antibody responses to Rhoptry-Associated Protein-1 (RAP-1) of Plasmodium falciparum parasites in humans from areas of different malaria endemicity
AU - Jakobsen, P H
AU - Kurtzhals, J A
AU - Riley, E M
AU - Hviid, L
AU - Theander, T G
AU - Morris-Jones, S
AU - Jensen, J B
AU - Bayoumi, R A
AU - Ridley, R G
AU - Greenwood, B M
N1 - Keywords: Adolescent; Adult; Aged; Animals; Antibodies, Protozoan; Antigens, Protozoan; Child; Child, Preschool; Cross-Sectional Studies; Endemic Diseases; Female; Gambia; Humans; Infant; Kenya; Longitudinal Studies; Malaria, Falciparum; Male; Middle Aged; Plasmodium falciparum; Protozoan Proteins; Recombinant Fusion Proteins; Sudan
PY - 1997
Y1 - 1997
N2 - Plasma IgM and IgG antibody reactivities against the recombinant Plasmodium falciparum protein, Rhoptry Associated Protein-1 (rRAP-1) were measured by ELISA in individuals from Sudan, Indonesia, Kenya and The Gambia living in areas of different malaria endemicity. IgG and IgM reactivities to rRAP-1 increased with malaria endemicity. IgG reactivities were associated with spleen rates in Indonesia with high malaria endemicity while IgM reactivities were associated with spleen rates in Kenya with low malaria endemicity. IgG and IgM reactivities to rRAP-1 increased during acute episodes of P. falciparum malaria in Sudanese adults and IgG reactivities remained high one month after treatment in all adults tested. Antibody reactivities to rRAP-1 in Gambian children in the dry season were higher in children with parasitaemia than in children without detectable parasitaemia. Antibody reactivities were not associated with protection against clinical episodes in the following rainy season but higher antibody reactivities were detectable at the end of the rainy season. There was no difference in antibody reactivity to rRAP-1 between Gambian children with mild or severe malaria.
AB - Plasma IgM and IgG antibody reactivities against the recombinant Plasmodium falciparum protein, Rhoptry Associated Protein-1 (rRAP-1) were measured by ELISA in individuals from Sudan, Indonesia, Kenya and The Gambia living in areas of different malaria endemicity. IgG and IgM reactivities to rRAP-1 increased with malaria endemicity. IgG reactivities were associated with spleen rates in Indonesia with high malaria endemicity while IgM reactivities were associated with spleen rates in Kenya with low malaria endemicity. IgG and IgM reactivities to rRAP-1 increased during acute episodes of P. falciparum malaria in Sudanese adults and IgG reactivities remained high one month after treatment in all adults tested. Antibody reactivities to rRAP-1 in Gambian children in the dry season were higher in children with parasitaemia than in children without detectable parasitaemia. Antibody reactivities were not associated with protection against clinical episodes in the following rainy season but higher antibody reactivities were detectable at the end of the rainy season. There was no difference in antibody reactivity to rRAP-1 between Gambian children with mild or severe malaria.
U2 - 10.1046/j.1365-3024.1997.d01-234.x
DO - 10.1046/j.1365-3024.1997.d01-234.x
M3 - Journal article
C2 - 9347514
VL - 19
SP - 387
EP - 393
JO - Parasite Immunology
JF - Parasite Immunology
SN - 0141-9838
IS - 9
ER -
ID: 6748160