Altered sodium intake affects plasma concentrations of BNP but not proBNP in healthy individuals and patients with compensated heart failure.

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Standard

Altered sodium intake affects plasma concentrations of BNP but not proBNP in healthy individuals and patients with compensated heart failure. / Damgaard, Morten; Goetze, Jens Peter; Norsk, Peter; Gadsbøll, Niels.

I: European Heart Journal, Bind 28, Nr. 22, 2007, s. 2726-31.

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Harvard

Damgaard, M, Goetze, JP, Norsk, P & Gadsbøll, N 2007, 'Altered sodium intake affects plasma concentrations of BNP but not proBNP in healthy individuals and patients with compensated heart failure.', European Heart Journal, bind 28, nr. 22, s. 2726-31. https://doi.org/10.1093/eurheartj/ehm396

APA

Damgaard, M., Goetze, J. P., Norsk, P., & Gadsbøll, N. (2007). Altered sodium intake affects plasma concentrations of BNP but not proBNP in healthy individuals and patients with compensated heart failure. European Heart Journal, 28(22), 2726-31. https://doi.org/10.1093/eurheartj/ehm396

Vancouver

Damgaard M, Goetze JP, Norsk P, Gadsbøll N. Altered sodium intake affects plasma concentrations of BNP but not proBNP in healthy individuals and patients with compensated heart failure. European Heart Journal. 2007;28(22):2726-31. https://doi.org/10.1093/eurheartj/ehm396

Author

Damgaard, Morten ; Goetze, Jens Peter ; Norsk, Peter ; Gadsbøll, Niels. / Altered sodium intake affects plasma concentrations of BNP but not proBNP in healthy individuals and patients with compensated heart failure. I: European Heart Journal. 2007 ; Bind 28, Nr. 22. s. 2726-31.

Bibtex

@article{3ef54370acd711ddb538000ea68e967b,
title = "Altered sodium intake affects plasma concentrations of BNP but not proBNP in healthy individuals and patients with compensated heart failure.",
abstract = "AIMS: Plasma B-type natriuretic peptide (BNP) and proBNP are promising markers for treatment of heart failure (HF), but the intra-individual biological variation is high. We investigated whether changes in sodium intake and posture contribute to this variation. METHODS AND RESULTS: A total of 12 healthy individuals and 12 patients with medically treated compensated HF were examined after 1 week of low (70 mmol [1.61 g] per day) and 1 week of high (250 mmol [5.75 g] per day) sodium intake. Plasma volume and plasma concentrations of BNP and proBNP were determined after 1 h in seated and 1 h in supine position. In healthy individuals, the plasma BNP concentration increased significantly on high sodium intake with a ratio (high sodium/low sodium) of 2.00 (1.32-3.03, P = 0.004). The corresponding values for HF patients were 1.69 (1.25-2.29, P = 0.003). The plasma BNP concentration changed modestly by a posture change, with a plasma BNP ratio (supine/seated) of 1.15 (1.07-1.14, P = 0.001) and 1.06 (0.99-1.24, P = 0.088) in healthy subjects and HF patients, respectively. Plasma proBNP concentrations were neither significantly affected by posture nor by sodium intake. CONCLUSION: Sodium intake has a considerable effect on plasma BNP and therefore contributes to the intra-individual variability. We suggest dietary sodium intake to be standardized at least 3 days prior to blood sampling for the determination of plasma BNP.",
author = "Morten Damgaard and Goetze, {Jens Peter} and Peter Norsk and Niels Gadsb{\o}ll",
note = "Keywords: Biological Markers; Cross-Over Studies; Heart Failure; Humans; Male; Middle Aged; Natriuretic Peptide, Brain; Peptide Fragments; Plasma Volume; Posture; Sodium Chloride, Dietary",
year = "2007",
doi = "10.1093/eurheartj/ehm396",
language = "English",
volume = "28",
pages = "2726--31",
journal = "European Heart Journal",
issn = "0195-668X",
publisher = "Oxford University Press",
number = "22",

}

RIS

TY - JOUR

T1 - Altered sodium intake affects plasma concentrations of BNP but not proBNP in healthy individuals and patients with compensated heart failure.

AU - Damgaard, Morten

AU - Goetze, Jens Peter

AU - Norsk, Peter

AU - Gadsbøll, Niels

N1 - Keywords: Biological Markers; Cross-Over Studies; Heart Failure; Humans; Male; Middle Aged; Natriuretic Peptide, Brain; Peptide Fragments; Plasma Volume; Posture; Sodium Chloride, Dietary

PY - 2007

Y1 - 2007

N2 - AIMS: Plasma B-type natriuretic peptide (BNP) and proBNP are promising markers for treatment of heart failure (HF), but the intra-individual biological variation is high. We investigated whether changes in sodium intake and posture contribute to this variation. METHODS AND RESULTS: A total of 12 healthy individuals and 12 patients with medically treated compensated HF were examined after 1 week of low (70 mmol [1.61 g] per day) and 1 week of high (250 mmol [5.75 g] per day) sodium intake. Plasma volume and plasma concentrations of BNP and proBNP were determined after 1 h in seated and 1 h in supine position. In healthy individuals, the plasma BNP concentration increased significantly on high sodium intake with a ratio (high sodium/low sodium) of 2.00 (1.32-3.03, P = 0.004). The corresponding values for HF patients were 1.69 (1.25-2.29, P = 0.003). The plasma BNP concentration changed modestly by a posture change, with a plasma BNP ratio (supine/seated) of 1.15 (1.07-1.14, P = 0.001) and 1.06 (0.99-1.24, P = 0.088) in healthy subjects and HF patients, respectively. Plasma proBNP concentrations were neither significantly affected by posture nor by sodium intake. CONCLUSION: Sodium intake has a considerable effect on plasma BNP and therefore contributes to the intra-individual variability. We suggest dietary sodium intake to be standardized at least 3 days prior to blood sampling for the determination of plasma BNP.

AB - AIMS: Plasma B-type natriuretic peptide (BNP) and proBNP are promising markers for treatment of heart failure (HF), but the intra-individual biological variation is high. We investigated whether changes in sodium intake and posture contribute to this variation. METHODS AND RESULTS: A total of 12 healthy individuals and 12 patients with medically treated compensated HF were examined after 1 week of low (70 mmol [1.61 g] per day) and 1 week of high (250 mmol [5.75 g] per day) sodium intake. Plasma volume and plasma concentrations of BNP and proBNP were determined after 1 h in seated and 1 h in supine position. In healthy individuals, the plasma BNP concentration increased significantly on high sodium intake with a ratio (high sodium/low sodium) of 2.00 (1.32-3.03, P = 0.004). The corresponding values for HF patients were 1.69 (1.25-2.29, P = 0.003). The plasma BNP concentration changed modestly by a posture change, with a plasma BNP ratio (supine/seated) of 1.15 (1.07-1.14, P = 0.001) and 1.06 (0.99-1.24, P = 0.088) in healthy subjects and HF patients, respectively. Plasma proBNP concentrations were neither significantly affected by posture nor by sodium intake. CONCLUSION: Sodium intake has a considerable effect on plasma BNP and therefore contributes to the intra-individual variability. We suggest dietary sodium intake to be standardized at least 3 days prior to blood sampling for the determination of plasma BNP.

U2 - 10.1093/eurheartj/ehm396

DO - 10.1093/eurheartj/ehm396

M3 - Journal article

C2 - 17942579

VL - 28

SP - 2726

EP - 2731

JO - European Heart Journal

JF - European Heart Journal

SN - 0195-668X

IS - 22

ER -

ID: 8466237