Affinity-purified human interleukin I is cytotoxic to isolated islets of Langerhans
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Affinity-purified human interleukin I is cytotoxic to isolated islets of Langerhans. / Mandrup-Poulsen, T; Bendtzen, K; Nerup, J; Dinarello, C A; Svenson, M; Nielsen, Jens Høiriis.
I: Diabetologia, Bind 29, Nr. 1, 01.1986, s. 63-7.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › fagfællebedømt
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T1 - Affinity-purified human interleukin I is cytotoxic to isolated islets of Langerhans
AU - Mandrup-Poulsen, T
AU - Bendtzen, K
AU - Nerup, J
AU - Dinarello, C A
AU - Svenson, M
AU - Nielsen, Jens Høiriis
PY - 1986/1
Y1 - 1986/1
N2 - Addition of highly purified human Interleukin-1 to the culture medium of isolated rat islets of Langerhans for 6 days led to 88% inhibition of glucose-induced insulin-release, reduction of islet contents of insulin and glucagon to 31% and 8% respectively, and disintegration of the islets. These effects were dose-dependent and reproducible when using three different Interleukin-1 preparations. Highly purified human Interleukin-2, Lymphotoxin, Leucocyte Migration Inhibitory Factor and Macrophage Migration Inhibitory Factor were ineffective. These findings suggest that Interleukin-1 may play an important role in the molecular mechanisms underlying autoimmune B-cell destruction leading to Type 1 (insulin-dependent) diabetes mellitus.
AB - Addition of highly purified human Interleukin-1 to the culture medium of isolated rat islets of Langerhans for 6 days led to 88% inhibition of glucose-induced insulin-release, reduction of islet contents of insulin and glucagon to 31% and 8% respectively, and disintegration of the islets. These effects were dose-dependent and reproducible when using three different Interleukin-1 preparations. Highly purified human Interleukin-2, Lymphotoxin, Leucocyte Migration Inhibitory Factor and Macrophage Migration Inhibitory Factor were ineffective. These findings suggest that Interleukin-1 may play an important role in the molecular mechanisms underlying autoimmune B-cell destruction leading to Type 1 (insulin-dependent) diabetes mellitus.
KW - Animals
KW - Glucagon
KW - Humans
KW - Insulin
KW - Interleukin-1
KW - Islets of Langerhans
KW - Male
KW - Rats
KW - Rats, Inbred Strains
M3 - Journal article
C2 - 3514344
VL - 29
SP - 63
EP - 67
JO - Diabetologia
JF - Diabetologia
SN - 0012-186X
IS - 1
ER -
ID: 47975100