Activation of AMP-activated protein kinase rapidly suppresses multiple pro-inflammatory pathways in adipocytes including IL-1 receptor-associated kinase-4 phosphorylation

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Standard

Activation of AMP-activated protein kinase rapidly suppresses multiple pro-inflammatory pathways in adipocytes including IL-1 receptor-associated kinase-4 phosphorylation. / Mancini, Sarah J; White, Anna D; Bijland, Silvia; Rutherford, Claire; Graham, Delyth; Richter, Erik A.; Viollet, Benoit; Touyz, Rhian M; Palmer, Timothy M; Salt, Ian P.

I: Molecular and Cellular Endocrinology, Bind 440, 2017, s. 44-56.

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Harvard

Mancini, SJ, White, AD, Bijland, S, Rutherford, C, Graham, D, Richter, EA, Viollet, B, Touyz, RM, Palmer, TM & Salt, IP 2017, 'Activation of AMP-activated protein kinase rapidly suppresses multiple pro-inflammatory pathways in adipocytes including IL-1 receptor-associated kinase-4 phosphorylation', Molecular and Cellular Endocrinology, bind 440, s. 44-56. https://doi.org/10.1016/j.mce.2016.11.010

APA

Mancini, S. J., White, A. D., Bijland, S., Rutherford, C., Graham, D., Richter, E. A., Viollet, B., Touyz, R. M., Palmer, T. M., & Salt, I. P. (2017). Activation of AMP-activated protein kinase rapidly suppresses multiple pro-inflammatory pathways in adipocytes including IL-1 receptor-associated kinase-4 phosphorylation. Molecular and Cellular Endocrinology, 440, 44-56. https://doi.org/10.1016/j.mce.2016.11.010

Vancouver

Mancini SJ, White AD, Bijland S, Rutherford C, Graham D, Richter EA o.a. Activation of AMP-activated protein kinase rapidly suppresses multiple pro-inflammatory pathways in adipocytes including IL-1 receptor-associated kinase-4 phosphorylation. Molecular and Cellular Endocrinology. 2017;440:44-56. https://doi.org/10.1016/j.mce.2016.11.010

Author

Mancini, Sarah J ; White, Anna D ; Bijland, Silvia ; Rutherford, Claire ; Graham, Delyth ; Richter, Erik A. ; Viollet, Benoit ; Touyz, Rhian M ; Palmer, Timothy M ; Salt, Ian P. / Activation of AMP-activated protein kinase rapidly suppresses multiple pro-inflammatory pathways in adipocytes including IL-1 receptor-associated kinase-4 phosphorylation. I: Molecular and Cellular Endocrinology. 2017 ; Bind 440. s. 44-56.

Bibtex

@article{f32149da21f140cebc015d4ea7488e3c,
title = "Activation of AMP-activated protein kinase rapidly suppresses multiple pro-inflammatory pathways in adipocytes including IL-1 receptor-associated kinase-4 phosphorylation",
abstract = "Inflammation of adipose tissue in obesity is associated with increased IL-1β, IL-6 and TNF-α secretion and proposed to contribute to insulin resistance. AMP-activated protein kinase (AMPK) regulates nutrient metabolism and is reported to have anti-inflammatory actions in adipose tissue, yet the mechanisms underlying this remain poorly characterised. The effect of AMPK activation on cytokine-stimulated proinflammatory signalling was therefore assessed in cultured adipocytes. AMPK activation inhibited IL-1β-stimulated CXCL10 secretion, associated with reduced interleukin-1 receptor associated kinase-4 (IRAK4) phosphorylation and downregulated MKK4/JNK and IKK/IκB/NFκB signalling. AMPK activation inhibited TNF-α-stimulated IKK/IκB/NFκB signalling but had no effect on JNK phosphorylation. The JAK/STAT3 pathway was also suppressed by AMPK after IL-6 stimulation and during adipogenesis. Adipose tissue from AMPKα1(-/-) mice exhibited increased JNK and STAT3 phosphorylation, supporting suppression of these distinct proinflammatory pathways by AMPK in vivo. The inhibition of multiple pro-inflammatory signalling pathways by AMPK may underlie the reported beneficial effects of AMPK activation in adipose tissue.",
keywords = "Faculty of Science, Adipocyte, AMP-activated protein kinase, Inflammation, Signalling",
author = "Mancini, {Sarah J} and White, {Anna D} and Silvia Bijland and Claire Rutherford and Delyth Graham and Richter, {Erik A.} and Benoit Viollet and Touyz, {Rhian M} and Palmer, {Timothy M} and Salt, {Ian P}",
note = "CURIS 2017 NEXS 003",
year = "2017",
doi = "10.1016/j.mce.2016.11.010",
language = "English",
volume = "440",
pages = "44--56",
journal = "Molecular and Cellular Endocrinology",
issn = "0303-7207",
publisher = "Elsevier Ireland Ltd",

}

RIS

TY - JOUR

T1 - Activation of AMP-activated protein kinase rapidly suppresses multiple pro-inflammatory pathways in adipocytes including IL-1 receptor-associated kinase-4 phosphorylation

AU - Mancini, Sarah J

AU - White, Anna D

AU - Bijland, Silvia

AU - Rutherford, Claire

AU - Graham, Delyth

AU - Richter, Erik A.

AU - Viollet, Benoit

AU - Touyz, Rhian M

AU - Palmer, Timothy M

AU - Salt, Ian P

N1 - CURIS 2017 NEXS 003

PY - 2017

Y1 - 2017

N2 - Inflammation of adipose tissue in obesity is associated with increased IL-1β, IL-6 and TNF-α secretion and proposed to contribute to insulin resistance. AMP-activated protein kinase (AMPK) regulates nutrient metabolism and is reported to have anti-inflammatory actions in adipose tissue, yet the mechanisms underlying this remain poorly characterised. The effect of AMPK activation on cytokine-stimulated proinflammatory signalling was therefore assessed in cultured adipocytes. AMPK activation inhibited IL-1β-stimulated CXCL10 secretion, associated with reduced interleukin-1 receptor associated kinase-4 (IRAK4) phosphorylation and downregulated MKK4/JNK and IKK/IκB/NFκB signalling. AMPK activation inhibited TNF-α-stimulated IKK/IκB/NFκB signalling but had no effect on JNK phosphorylation. The JAK/STAT3 pathway was also suppressed by AMPK after IL-6 stimulation and during adipogenesis. Adipose tissue from AMPKα1(-/-) mice exhibited increased JNK and STAT3 phosphorylation, supporting suppression of these distinct proinflammatory pathways by AMPK in vivo. The inhibition of multiple pro-inflammatory signalling pathways by AMPK may underlie the reported beneficial effects of AMPK activation in adipose tissue.

AB - Inflammation of adipose tissue in obesity is associated with increased IL-1β, IL-6 and TNF-α secretion and proposed to contribute to insulin resistance. AMP-activated protein kinase (AMPK) regulates nutrient metabolism and is reported to have anti-inflammatory actions in adipose tissue, yet the mechanisms underlying this remain poorly characterised. The effect of AMPK activation on cytokine-stimulated proinflammatory signalling was therefore assessed in cultured adipocytes. AMPK activation inhibited IL-1β-stimulated CXCL10 secretion, associated with reduced interleukin-1 receptor associated kinase-4 (IRAK4) phosphorylation and downregulated MKK4/JNK and IKK/IκB/NFκB signalling. AMPK activation inhibited TNF-α-stimulated IKK/IκB/NFκB signalling but had no effect on JNK phosphorylation. The JAK/STAT3 pathway was also suppressed by AMPK after IL-6 stimulation and during adipogenesis. Adipose tissue from AMPKα1(-/-) mice exhibited increased JNK and STAT3 phosphorylation, supporting suppression of these distinct proinflammatory pathways by AMPK in vivo. The inhibition of multiple pro-inflammatory signalling pathways by AMPK may underlie the reported beneficial effects of AMPK activation in adipose tissue.

KW - Faculty of Science

KW - Adipocyte

KW - AMP-activated protein kinase

KW - Inflammation

KW - Signalling

U2 - 10.1016/j.mce.2016.11.010

DO - 10.1016/j.mce.2016.11.010

M3 - Journal article

C2 - 27840174

VL - 440

SP - 44

EP - 56

JO - Molecular and Cellular Endocrinology

JF - Molecular and Cellular Endocrinology

SN - 0303-7207

ER -

ID: 168931504