Accelerated progression of white matter hyperintensities and subsequent risk of mortality: a 12-year follow-up study

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Accelerated progression of white matter hyperintensities and subsequent risk of mortality : a 12-year follow-up study. / Sabayan, Behnam; van der Grond, Jeroen; Westendorp, Rudi G; van Buchem, Mark A; de Craen, Anton J M.

I: Neurobiology of Aging, Bind 36, Nr. 6, 06.2015, s. 2130–2135.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Sabayan, B, van der Grond, J, Westendorp, RG, van Buchem, MA & de Craen, AJM 2015, 'Accelerated progression of white matter hyperintensities and subsequent risk of mortality: a 12-year follow-up study', Neurobiology of Aging, bind 36, nr. 6, s. 2130–2135. https://doi.org/10.1016/j.neurobiolaging.2015.03.003

APA

Sabayan, B., van der Grond, J., Westendorp, R. G., van Buchem, M. A., & de Craen, A. J. M. (2015). Accelerated progression of white matter hyperintensities and subsequent risk of mortality: a 12-year follow-up study. Neurobiology of Aging, 36(6), 2130–2135. https://doi.org/10.1016/j.neurobiolaging.2015.03.003

Vancouver

Sabayan B, van der Grond J, Westendorp RG, van Buchem MA, de Craen AJM. Accelerated progression of white matter hyperintensities and subsequent risk of mortality: a 12-year follow-up study. Neurobiology of Aging. 2015 jun;36(6):2130–2135. https://doi.org/10.1016/j.neurobiolaging.2015.03.003

Author

Sabayan, Behnam ; van der Grond, Jeroen ; Westendorp, Rudi G ; van Buchem, Mark A ; de Craen, Anton J M. / Accelerated progression of white matter hyperintensities and subsequent risk of mortality : a 12-year follow-up study. I: Neurobiology of Aging. 2015 ; Bind 36, Nr. 6. s. 2130–2135.

Bibtex

@article{668b9b4e567541928ebd40aff916a5bc,
title = "Accelerated progression of white matter hyperintensities and subsequent risk of mortality: a 12-year follow-up study",
abstract = "We examined the association of accelerated progression of white matter hyperintensities (WMH) with mortality outcomes in 534 older subjects at risk for cardiovascular disease. Using brain magnetic resonance imaging, volume of WMH was measured 2 times in an average of 33 months apart. After the second magnetic resonance imaging, occurrence of death was recorded during 12 years of follow-up. In multivariable analyses, each mL/y increase in global WMH was associated with 1.22-fold (95{\%} confidence interval [CI], 1.09-1.37) higher risk of all-cause mortality, 1.29-fold (95{\%} CI, 1.06-1.56) higher risk of cardiovascular mortality, and 1.20-fold (95{\%} CI, 1.02-1.40) higher risk of noncardiovascular mortality. Each mL/y increase in periventricular WMH was associated with 1.22-fold (95{\%} CI, 1.08-37) higher risk of all-cause mortality and 1.24-fold (95{\%} CI, 1.06-1.44) higher risk of noncardiovascular mortality. Conversely, deep cortical WMH was only associated with cardiovascular mortality (1.92-fold, 95{\%} CI, 1.12-3.30). Accelerated progression of WMH is linked with mortality risk in old age. Progression of periventricular WMH associates with noncardiovascular mortality, whereas progression of deep cortical WMH associates with cardiovascular mortality.",
author = "Behnam Sabayan and {van der Grond}, Jeroen and Westendorp, {Rudi G} and {van Buchem}, {Mark A} and {de Craen}, {Anton J M}",
note = "Copyright {\circledC} 2015 Elsevier Inc. All rights reserved.",
year = "2015",
month = "6",
doi = "10.1016/j.neurobiolaging.2015.03.003",
language = "English",
volume = "36",
pages = "2130–2135",
journal = "Neurobiology of Aging",
issn = "0197-4580",
publisher = "Elsevier",
number = "6",

}

RIS

TY - JOUR

T1 - Accelerated progression of white matter hyperintensities and subsequent risk of mortality

T2 - a 12-year follow-up study

AU - Sabayan, Behnam

AU - van der Grond, Jeroen

AU - Westendorp, Rudi G

AU - van Buchem, Mark A

AU - de Craen, Anton J M

N1 - Copyright © 2015 Elsevier Inc. All rights reserved.

PY - 2015/6

Y1 - 2015/6

N2 - We examined the association of accelerated progression of white matter hyperintensities (WMH) with mortality outcomes in 534 older subjects at risk for cardiovascular disease. Using brain magnetic resonance imaging, volume of WMH was measured 2 times in an average of 33 months apart. After the second magnetic resonance imaging, occurrence of death was recorded during 12 years of follow-up. In multivariable analyses, each mL/y increase in global WMH was associated with 1.22-fold (95% confidence interval [CI], 1.09-1.37) higher risk of all-cause mortality, 1.29-fold (95% CI, 1.06-1.56) higher risk of cardiovascular mortality, and 1.20-fold (95% CI, 1.02-1.40) higher risk of noncardiovascular mortality. Each mL/y increase in periventricular WMH was associated with 1.22-fold (95% CI, 1.08-37) higher risk of all-cause mortality and 1.24-fold (95% CI, 1.06-1.44) higher risk of noncardiovascular mortality. Conversely, deep cortical WMH was only associated with cardiovascular mortality (1.92-fold, 95% CI, 1.12-3.30). Accelerated progression of WMH is linked with mortality risk in old age. Progression of periventricular WMH associates with noncardiovascular mortality, whereas progression of deep cortical WMH associates with cardiovascular mortality.

AB - We examined the association of accelerated progression of white matter hyperintensities (WMH) with mortality outcomes in 534 older subjects at risk for cardiovascular disease. Using brain magnetic resonance imaging, volume of WMH was measured 2 times in an average of 33 months apart. After the second magnetic resonance imaging, occurrence of death was recorded during 12 years of follow-up. In multivariable analyses, each mL/y increase in global WMH was associated with 1.22-fold (95% confidence interval [CI], 1.09-1.37) higher risk of all-cause mortality, 1.29-fold (95% CI, 1.06-1.56) higher risk of cardiovascular mortality, and 1.20-fold (95% CI, 1.02-1.40) higher risk of noncardiovascular mortality. Each mL/y increase in periventricular WMH was associated with 1.22-fold (95% CI, 1.08-37) higher risk of all-cause mortality and 1.24-fold (95% CI, 1.06-1.44) higher risk of noncardiovascular mortality. Conversely, deep cortical WMH was only associated with cardiovascular mortality (1.92-fold, 95% CI, 1.12-3.30). Accelerated progression of WMH is linked with mortality risk in old age. Progression of periventricular WMH associates with noncardiovascular mortality, whereas progression of deep cortical WMH associates with cardiovascular mortality.

U2 - 10.1016/j.neurobiolaging.2015.03.003

DO - 10.1016/j.neurobiolaging.2015.03.003

M3 - Journal article

C2 - 25842006

VL - 36

SP - 2130

EP - 2135

JO - Neurobiology of Aging

JF - Neurobiology of Aging

SN - 0197-4580

IS - 6

ER -

ID: 140395511