A PRDM16-Driven Metabolic Signal from Adipocytes Regulates Precursor Cell Fate

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Standard

A PRDM16-Driven Metabolic Signal from Adipocytes Regulates Precursor Cell Fate. / Wang, Wenshan; Ishibashi, Jeff; Trefely, Sophie; Shao, Mengle; Cowan, Alexis J.; Sakers, Alexander; Lim, Hee Woong; O'Connor, Sean; Doan, Mary T.; Cohen, Paul; Baur, Joseph A.; King, M. Todd; Veech, Richard L.; Won, Kyoung Jae; Rabinowitz, Joshua D.; Snyder, Nathaniel W.; Gupta, Rana K.; Seale, Patrick.

I: Cell Metabolism, Bind 30, Nr. 1, 02.07.2019, s. 174-189.e5.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Wang, W, Ishibashi, J, Trefely, S, Shao, M, Cowan, AJ, Sakers, A, Lim, HW, O'Connor, S, Doan, MT, Cohen, P, Baur, JA, King, MT, Veech, RL, Won, KJ, Rabinowitz, JD, Snyder, NW, Gupta, RK & Seale, P 2019, 'A PRDM16-Driven Metabolic Signal from Adipocytes Regulates Precursor Cell Fate', Cell Metabolism, bind 30, nr. 1, s. 174-189.e5. https://doi.org/10.1016/j.cmet.2019.05.005

APA

Wang, W., Ishibashi, J., Trefely, S., Shao, M., Cowan, A. J., Sakers, A., Lim, H. W., O'Connor, S., Doan, M. T., Cohen, P., Baur, J. A., King, M. T., Veech, R. L., Won, K. J., Rabinowitz, J. D., Snyder, N. W., Gupta, R. K., & Seale, P. (2019). A PRDM16-Driven Metabolic Signal from Adipocytes Regulates Precursor Cell Fate. Cell Metabolism, 30(1), 174-189.e5. https://doi.org/10.1016/j.cmet.2019.05.005

Vancouver

Wang W, Ishibashi J, Trefely S, Shao M, Cowan AJ, Sakers A o.a. A PRDM16-Driven Metabolic Signal from Adipocytes Regulates Precursor Cell Fate. Cell Metabolism. 2019 jul. 2;30(1):174-189.e5. https://doi.org/10.1016/j.cmet.2019.05.005

Author

Wang, Wenshan ; Ishibashi, Jeff ; Trefely, Sophie ; Shao, Mengle ; Cowan, Alexis J. ; Sakers, Alexander ; Lim, Hee Woong ; O'Connor, Sean ; Doan, Mary T. ; Cohen, Paul ; Baur, Joseph A. ; King, M. Todd ; Veech, Richard L. ; Won, Kyoung Jae ; Rabinowitz, Joshua D. ; Snyder, Nathaniel W. ; Gupta, Rana K. ; Seale, Patrick. / A PRDM16-Driven Metabolic Signal from Adipocytes Regulates Precursor Cell Fate. I: Cell Metabolism. 2019 ; Bind 30, Nr. 1. s. 174-189.e5.

Bibtex

@article{c92ec588387f49f2adc4752c617b4584,

title = "A PRDM16-Driven Metabolic Signal from Adipocytes Regulates Precursor Cell Fate",

abstract = "The precursor cells for metabolically beneficial beige adipocytes can alternatively become fibrogenic and contribute to adipose fibrosis. We found that cold exposure or β3-adrenergic agonist treatment of mice decreased the fibrogenic profile of precursor cells and stimulated beige adipocyte differentiation. This fibrogenic-to-adipogenic transition was impaired in aged animals, correlating with reduced adipocyte expression of the transcription factor PRDM16. Genetic loss of Prdm16 mimicked the effect of aging in promoting fibrosis, whereas increasing PRDM16 in aged mice decreased fibrosis and restored beige adipose development. PRDM16-expressing adipose cells secreted the metabolite β-hydroxybutyrate (BHB), which blocked precursor fibrogenesis and facilitated beige adipogenesis. BHB catabolism in precursor cells, mediated by BDH1, was required for beige fat differentiation in vivo. Finally, dietary BHB supplementation in aged animals reduced adipose fibrosis and promoted beige fat formation. Together, our results demonstrate that adipocytes secrete a metabolite signal that controls beige fat remodeling.",

keywords = "adipose fibrosis, BDH1, beige fat, beta hydroxybutyrate, brown fat, fibro-adipogenic progenitor, PRDM16, UCP1",

author = "Wenshan Wang and Jeff Ishibashi and Sophie Trefely and Mengle Shao and Cowan, {Alexis J.} and Alexander Sakers and Lim, {Hee Woong} and Sean O'Connor and Doan, {Mary T.} and Paul Cohen and Baur, {Joseph A.} and King, {M. Todd} and Veech, {Richard L.} and Won, {Kyoung Jae} and Rabinowitz, {Joshua D.} and Snyder, {Nathaniel W.} and Gupta, {Rana K.} and Patrick Seale",

year = "2019",

month = jul,

day = "2",

doi = "10.1016/j.cmet.2019.05.005",

language = "English",

volume = "30",

pages = "174--189.e5",

journal = "Cell Metabolism",

issn = "1550-4131",

publisher = "Cell Press",

number = "1",

}

RIS

TY - JOUR

T1 - A PRDM16-Driven Metabolic Signal from Adipocytes Regulates Precursor Cell Fate

AU - Wang, Wenshan

AU - Ishibashi, Jeff

AU - Trefely, Sophie

AU - Shao, Mengle

AU - Cowan, Alexis J.

AU - Sakers, Alexander

AU - Lim, Hee Woong

AU - O'Connor, Sean

AU - Doan, Mary T.

AU - Cohen, Paul

AU - Baur, Joseph A.

AU - King, M. Todd

AU - Veech, Richard L.

AU - Won, Kyoung Jae

AU - Rabinowitz, Joshua D.

AU - Snyder, Nathaniel W.

AU - Gupta, Rana K.

AU - Seale, Patrick

PY - 2019/7/2

Y1 - 2019/7/2

N2 - The precursor cells for metabolically beneficial beige adipocytes can alternatively become fibrogenic and contribute to adipose fibrosis. We found that cold exposure or β3-adrenergic agonist treatment of mice decreased the fibrogenic profile of precursor cells and stimulated beige adipocyte differentiation. This fibrogenic-to-adipogenic transition was impaired in aged animals, correlating with reduced adipocyte expression of the transcription factor PRDM16. Genetic loss of Prdm16 mimicked the effect of aging in promoting fibrosis, whereas increasing PRDM16 in aged mice decreased fibrosis and restored beige adipose development. PRDM16-expressing adipose cells secreted the metabolite β-hydroxybutyrate (BHB), which blocked precursor fibrogenesis and facilitated beige adipogenesis. BHB catabolism in precursor cells, mediated by BDH1, was required for beige fat differentiation in vivo. Finally, dietary BHB supplementation in aged animals reduced adipose fibrosis and promoted beige fat formation. Together, our results demonstrate that adipocytes secrete a metabolite signal that controls beige fat remodeling.

AB - The precursor cells for metabolically beneficial beige adipocytes can alternatively become fibrogenic and contribute to adipose fibrosis. We found that cold exposure or β3-adrenergic agonist treatment of mice decreased the fibrogenic profile of precursor cells and stimulated beige adipocyte differentiation. This fibrogenic-to-adipogenic transition was impaired in aged animals, correlating with reduced adipocyte expression of the transcription factor PRDM16. Genetic loss of Prdm16 mimicked the effect of aging in promoting fibrosis, whereas increasing PRDM16 in aged mice decreased fibrosis and restored beige adipose development. PRDM16-expressing adipose cells secreted the metabolite β-hydroxybutyrate (BHB), which blocked precursor fibrogenesis and facilitated beige adipogenesis. BHB catabolism in precursor cells, mediated by BDH1, was required for beige fat differentiation in vivo. Finally, dietary BHB supplementation in aged animals reduced adipose fibrosis and promoted beige fat formation. Together, our results demonstrate that adipocytes secrete a metabolite signal that controls beige fat remodeling.

KW - adipose fibrosis

KW - BDH1

KW - beige fat

KW - beta hydroxybutyrate

KW - brown fat

KW - fibro-adipogenic progenitor

KW - PRDM16

KW - UCP1

UR - http://www.scopus.com/inward/record.url?scp=85067899280&partnerID=8YFLogxK

U2 - 10.1016/j.cmet.2019.05.005

DO - 10.1016/j.cmet.2019.05.005

M3 - Journal article

C2 - 31155495

AN - SCOPUS:85067899280

VL - 30

SP - 174-189.e5

JO - Cell Metabolism

JF - Cell Metabolism

SN - 1550-4131

IS - 1

ER -

ID: 237099030