A new health care index predicts short term mortality for TB and HIV co-infected people

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A new health care index predicts short term mortality for TB and HIV co-infected people. / Roen, A. O.; Podlekareva, D.; Miller, R. F.; Mocroft, A.; Panteleev, A.; Skrahina, A.; Miro, J. M.; Cayla, J. A.; Tetradov, S.; Derisova, E.; Furrer, H.; Losso, M. H.; Vassilenko, A.; Girardi, E.; Lundgren, J. D.; Post, F. A.; Kirk, O.

I: International Journal of Tuberculosis and Lung Disease, Bind 24, Nr. 9, 2020, s. 956-962.

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Harvard

Roen, AO, Podlekareva, D, Miller, RF, Mocroft, A, Panteleev, A, Skrahina, A, Miro, JM, Cayla, JA, Tetradov, S, Derisova, E, Furrer, H, Losso, MH, Vassilenko, A, Girardi, E, Lundgren, JD, Post, FA & Kirk, O 2020, 'A new health care index predicts short term mortality for TB and HIV co-infected people', International Journal of Tuberculosis and Lung Disease, bind 24, nr. 9, s. 956-962. https://doi.org/10.5588/ijtld.19.0568

APA

Roen, A. O., Podlekareva, D., Miller, R. F., Mocroft, A., Panteleev, A., Skrahina, A., Miro, J. M., Cayla, J. A., Tetradov, S., Derisova, E., Furrer, H., Losso, M. H., Vassilenko, A., Girardi, E., Lundgren, J. D., Post, F. A., & Kirk, O. (2020). A new health care index predicts short term mortality for TB and HIV co-infected people. International Journal of Tuberculosis and Lung Disease, 24(9), 956-962. https://doi.org/10.5588/ijtld.19.0568

Vancouver

Roen AO, Podlekareva D, Miller RF, Mocroft A, Panteleev A, Skrahina A o.a. A new health care index predicts short term mortality for TB and HIV co-infected people. International Journal of Tuberculosis and Lung Disease. 2020;24(9):956-962. https://doi.org/10.5588/ijtld.19.0568

Author

Roen, A. O. ; Podlekareva, D. ; Miller, R. F. ; Mocroft, A. ; Panteleev, A. ; Skrahina, A. ; Miro, J. M. ; Cayla, J. A. ; Tetradov, S. ; Derisova, E. ; Furrer, H. ; Losso, M. H. ; Vassilenko, A. ; Girardi, E. ; Lundgren, J. D. ; Post, F. A. ; Kirk, O. / A new health care index predicts short term mortality for TB and HIV co-infected people. I: International Journal of Tuberculosis and Lung Disease. 2020 ; Bind 24, Nr. 9. s. 956-962.

Bibtex

@article{e7fdb60abdc84d31b36acf974e56b548,
title = "A new health care index predicts short term mortality for TB and HIV co-infected people",
abstract = "BACKGROUND: Using 2004–2007 TB:HIV Study data from Europe and Latin America, we previously generated a health care index (HCI) for TB and HIV co-infected people. With improvements in diagnostic and management practices, we have now updated the HCI with new data. METHODS: We evaluated nine aspects of health care in Cox proportional hazards models on time from TB diagnosis to death. Kaplan-Meier methods were used to estimate the probability of death by HCI quartile. RESULTS: Of 1396 eligible individuals (72% male, 59% from Eastern Europe), 269 died within 12 months. Use of rifamycin/isoniazid/pyrazinamide-based treatment (HR 0.67, 95% CI 0.50–0.89), TB drug susceptibility testing (DST) and number of active TB drugs (DST {\th},3 drugs (HR 1.09, 95% CI 0.80–1.48), DST {\th} ≥3 drugs (HR 0.49, 95% CI 0.35–0.70) vs. no DST), recent HIV-RNA measurement (HR 0.64, 95% CI 0.50–0.82) and combination antiretroviral therapy use (HR 0.72, 95% CI 0.53–0.97) were associated with mortality. These factors contributed respectively 5, –1, 8, 5 and 4 to the HCI. Lower HCI was associated with an increased probability of death; 30% (95% CI 26–35) vs. 9% (95% CI 6–13) in the lowest vs. the highest quartile. CONCLUSION: We found five potentially modifiable health care components that were associated with mortality among TB-HIV positive individuals. Validation of our HCI in other TB cohorts could enhance our findings.",
keywords = "Health care index, HIV, TB",
author = "Roen, {A. O.} and D. Podlekareva and Miller, {R. F.} and A. Mocroft and A. Panteleev and A. Skrahina and Miro, {J. M.} and Cayla, {J. A.} and S. Tetradov and E. Derisova and H. Furrer and Losso, {M. H.} and A. Vassilenko and E. Girardi and Lundgren, {J. D.} and Post, {F. A.} and O. Kirk",
year = "2020",
doi = "10.5588/ijtld.19.0568",
language = "English",
volume = "24",
pages = "956--962",
journal = "International Journal of Tuberculosis and Lung Disease",
issn = "1027-3719",
publisher = "International Union against Tuberculosis and Lung Disease (I U A T L D)",
number = "9",

}

RIS

TY - JOUR

T1 - A new health care index predicts short term mortality for TB and HIV co-infected people

AU - Roen, A. O.

AU - Podlekareva, D.

AU - Miller, R. F.

AU - Mocroft, A.

AU - Panteleev, A.

AU - Skrahina, A.

AU - Miro, J. M.

AU - Cayla, J. A.

AU - Tetradov, S.

AU - Derisova, E.

AU - Furrer, H.

AU - Losso, M. H.

AU - Vassilenko, A.

AU - Girardi, E.

AU - Lundgren, J. D.

AU - Post, F. A.

AU - Kirk, O.

PY - 2020

Y1 - 2020

N2 - BACKGROUND: Using 2004–2007 TB:HIV Study data from Europe and Latin America, we previously generated a health care index (HCI) for TB and HIV co-infected people. With improvements in diagnostic and management practices, we have now updated the HCI with new data. METHODS: We evaluated nine aspects of health care in Cox proportional hazards models on time from TB diagnosis to death. Kaplan-Meier methods were used to estimate the probability of death by HCI quartile. RESULTS: Of 1396 eligible individuals (72% male, 59% from Eastern Europe), 269 died within 12 months. Use of rifamycin/isoniazid/pyrazinamide-based treatment (HR 0.67, 95% CI 0.50–0.89), TB drug susceptibility testing (DST) and number of active TB drugs (DST þ,3 drugs (HR 1.09, 95% CI 0.80–1.48), DST þ ≥3 drugs (HR 0.49, 95% CI 0.35–0.70) vs. no DST), recent HIV-RNA measurement (HR 0.64, 95% CI 0.50–0.82) and combination antiretroviral therapy use (HR 0.72, 95% CI 0.53–0.97) were associated with mortality. These factors contributed respectively 5, –1, 8, 5 and 4 to the HCI. Lower HCI was associated with an increased probability of death; 30% (95% CI 26–35) vs. 9% (95% CI 6–13) in the lowest vs. the highest quartile. CONCLUSION: We found five potentially modifiable health care components that were associated with mortality among TB-HIV positive individuals. Validation of our HCI in other TB cohorts could enhance our findings.

AB - BACKGROUND: Using 2004–2007 TB:HIV Study data from Europe and Latin America, we previously generated a health care index (HCI) for TB and HIV co-infected people. With improvements in diagnostic and management practices, we have now updated the HCI with new data. METHODS: We evaluated nine aspects of health care in Cox proportional hazards models on time from TB diagnosis to death. Kaplan-Meier methods were used to estimate the probability of death by HCI quartile. RESULTS: Of 1396 eligible individuals (72% male, 59% from Eastern Europe), 269 died within 12 months. Use of rifamycin/isoniazid/pyrazinamide-based treatment (HR 0.67, 95% CI 0.50–0.89), TB drug susceptibility testing (DST) and number of active TB drugs (DST þ,3 drugs (HR 1.09, 95% CI 0.80–1.48), DST þ ≥3 drugs (HR 0.49, 95% CI 0.35–0.70) vs. no DST), recent HIV-RNA measurement (HR 0.64, 95% CI 0.50–0.82) and combination antiretroviral therapy use (HR 0.72, 95% CI 0.53–0.97) were associated with mortality. These factors contributed respectively 5, –1, 8, 5 and 4 to the HCI. Lower HCI was associated with an increased probability of death; 30% (95% CI 26–35) vs. 9% (95% CI 6–13) in the lowest vs. the highest quartile. CONCLUSION: We found five potentially modifiable health care components that were associated with mortality among TB-HIV positive individuals. Validation of our HCI in other TB cohorts could enhance our findings.

KW - Health care index

KW - HIV

KW - TB

U2 - 10.5588/ijtld.19.0568

DO - 10.5588/ijtld.19.0568

M3 - Journal article

C2 - 33156764

AN - SCOPUS:85095802544

VL - 24

SP - 956

EP - 962

JO - International Journal of Tuberculosis and Lung Disease

JF - International Journal of Tuberculosis and Lung Disease

SN - 1027-3719

IS - 9

ER -

ID: 256219027