A cross-sectional study of functional and metabolic changes during aging through the lifespan in male mice
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- elife-62952-v2
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Aging is associated with distinct phenotypical, physiological, and functional changes, leading to disease and death. The progression of aging-related traits varies widely among individuals, influenced by their environment, lifestyle, and genetics. In this study, we conducted physiologic and functional tests cross-sectionally throughout the entire lifespan of male C57BL/6N mice. In parallel, metabolomics analyses in serum, brain, liver, heart, and skeletal muscle were also performed to identify signatures associated with frailty and age-dependent functional decline. Our findings indicate that declines in gait speed as a function of age and frailty are associated with a dramatic increase in the energetic cost of physical activity and decreases in working capacity. Aging and functional decline prompt organs to rewire their metabolism and substrate selection and toward redox-related pathways, mainly in liver and heart. Collectively, the data provide a framework to further understand and characterize processes of aging at the individual organism and organ levels.
Originalsprog | Engelsk |
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Artikelnummer | e62952 |
Tidsskrift | eLife |
Vol/bind | 10 |
Antal sider | 25 |
ISSN | 2050-084X |
DOI | |
Status | Udgivet - 2021 |
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