A case of thrombocytopenia and multiple thromboses after vaccination with ChAdOx1 nCoV-19 against SARS-CoV-2
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A case of thrombocytopenia and multiple thromboses after vaccination with ChAdOx1 nCoV-19 against SARS-CoV-2. / Sorensen, Anne Louise Tolboll; Rolland, Magalie; Hartmann, Jacob; Harboe, Zitta Barrella; Roed, Casper; Jensen, Tomas O.; Kolte, Lilian; Fassi, Daniel El; Hillingso, Jens; Radziwon-Balicka, Aneta; Soyka, Robert Sebastian; Hansen, Klaus; Kirkby, Nikolai; Goetze, Jens P.; Gybel-Brask, Mikkel; Leinoe, Eva Birgitte; Hvas, Anne Mette; Kampmann, Peter; Stensballe, Jakob.
I: Blood advances, Bind 5, Nr. 12, 2021, s. 2569-2574.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - A case of thrombocytopenia and multiple thromboses after vaccination with ChAdOx1 nCoV-19 against SARS-CoV-2
AU - Sorensen, Anne Louise Tolboll
AU - Rolland, Magalie
AU - Hartmann, Jacob
AU - Harboe, Zitta Barrella
AU - Roed, Casper
AU - Jensen, Tomas O.
AU - Kolte, Lilian
AU - Fassi, Daniel El
AU - Hillingso, Jens
AU - Radziwon-Balicka, Aneta
AU - Soyka, Robert Sebastian
AU - Hansen, Klaus
AU - Kirkby, Nikolai
AU - Goetze, Jens P.
AU - Gybel-Brask, Mikkel
AU - Leinoe, Eva Birgitte
AU - Hvas, Anne Mette
AU - Kampmann, Peter
AU - Stensballe, Jakob
N1 - Publisher Copyright: © 2021 American Society of Hematology. All rights reserved.
PY - 2021
Y1 - 2021
N2 - Recently, reports of severe thromboses, thrombocytopenia, and hemorrhage in persons vaccinated with the chimpanzee adenovirus-vectored vaccine (ChAdOx1 nCoV-19, AZD1222, Vaxzevria; Oxford/AstraZeneca) against severe acute respiratory syndrome coronavirus 2 have emerged. We describe an otherwise healthy 30-year-old woman who developed thrombocytopenia, ecchymosis, portal vein thrombosis, and cerebral venous sinus thrombosis the second week after she received the ChAdOx1 nCoV-19 vaccine. Extensive diagnostic workup for thrombosis predispositions showed heterozygosity for the prothrombin mutation, but no evidence of myeloproliferative neoplasia or infectious or autoimmune diseases. Her only temporary risk factor was long-Term use of oral contraceptive pills (OCPs). Although both the prothrombin mutation and use of OCPs predispose to portal and cerebral vein thrombosis, the occurrence of multiple thromboses within a short time and the associated pattern of thrombocytopenia and consumption coagulopathy are highly unusual. A maximum 4T heparin-induced thrombocytopenia (HIT) score and a positive immunoassay for anti-platelet factor 4/heparin antibodies identified autoimmune HIT as a potential pathogenic mechanism. Although causality has not been established, our case emphasizes the importance of clinical awareness. Further studies of this potentially new clinical entity have suggested that it should be regarded as a vaccine-induced immune thrombotic thrombocytopenia.
AB - Recently, reports of severe thromboses, thrombocytopenia, and hemorrhage in persons vaccinated with the chimpanzee adenovirus-vectored vaccine (ChAdOx1 nCoV-19, AZD1222, Vaxzevria; Oxford/AstraZeneca) against severe acute respiratory syndrome coronavirus 2 have emerged. We describe an otherwise healthy 30-year-old woman who developed thrombocytopenia, ecchymosis, portal vein thrombosis, and cerebral venous sinus thrombosis the second week after she received the ChAdOx1 nCoV-19 vaccine. Extensive diagnostic workup for thrombosis predispositions showed heterozygosity for the prothrombin mutation, but no evidence of myeloproliferative neoplasia or infectious or autoimmune diseases. Her only temporary risk factor was long-Term use of oral contraceptive pills (OCPs). Although both the prothrombin mutation and use of OCPs predispose to portal and cerebral vein thrombosis, the occurrence of multiple thromboses within a short time and the associated pattern of thrombocytopenia and consumption coagulopathy are highly unusual. A maximum 4T heparin-induced thrombocytopenia (HIT) score and a positive immunoassay for anti-platelet factor 4/heparin antibodies identified autoimmune HIT as a potential pathogenic mechanism. Although causality has not been established, our case emphasizes the importance of clinical awareness. Further studies of this potentially new clinical entity have suggested that it should be regarded as a vaccine-induced immune thrombotic thrombocytopenia.
U2 - 10.1182/bloodadvances.2021004904
DO - 10.1182/bloodadvances.2021004904
M3 - Journal article
C2 - 34137813
AN - SCOPUS:85108710400
VL - 5
SP - 2569
EP - 2574
JO - Blood advances
JF - Blood advances
SN - 2473-9529
IS - 12
ER -
ID: 273645120