Susheel Singh
Medlem af:
GLURP team
Aktuel forskning
- Development of multi-stage (asexual and sexual) malaria vaccine candidate.
- VLP technology as a vaccine delivery system.
- Apply the VLP-based antigen delivery platform to produce combination malaria vaccine (using promising antigen targets from liver stage, blood stage and transmission blocking stage).
- Use the VLP-based antigen delivery platform to produce combination vaccine against Japanese Encephalitis Virus (JEV) (using the Envelope protein from major prevalent genotypes and transmission blocking: mosGCTL-7, a C-type lectin protein which plays crucial role in JEV transmission).
- Parasitic genotyping, production of antigens for immunization in small rodents and serological studies.
- Developing robust and reliable bioassays for assessing the efficacy of vaccine clinical trials.
Udvalgte publikationer
- Udgivet
Unravelling the immune signature of Plasmodium falciparum transmission-reducing immunity
Stone, W. J. R., Campo, J. J., Ouédraogo, A. L., Meerstein-Kessel, L., Morlais, I., Da, D., Cohuet, A., Nsango, S., Sutherland, C. J., van de Vegte-Bolmer, M., Siebelink-Stoter, R., van Gemert, G., Graumans, W., Lanke, K., Shandling, A. D., Pablo, J. V., Teng, A. A., Jones, S., de Jong, R. M., Fabra-García, A., Bradley, J., Roeffen, W., Lasonder, E., Gremo, G., Schwarzer, E., Janse, C. J., Singh, Susheel, Theisen, Michael, Felgner, P., Marti, M., Drakeley, C., Sauerwein, R., Bousema, T. & Jore, M. M., 8 feb. 2018, I: Nature Communications. 9, 1, 14 s., 558.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
- Udgivet
Dynamics of anti-MSP3 and Pfs230 antibody responses and multiplicity of infection in asymptomatic children from southern Ghana
Amoah, L. E., Acquah, F. K., Ayanful-Torgby, R., Oppong, A., Abankwa, J., Obboh, E. K., Singh, Susheel & Theisen, Michael, 5 jan. 2018, I: Parasites & Vectors. 11, 1, 9 s., 13.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
- Udgivet
Expression, Purification and Characterization of GMZ2'.10C, a Complex Disulphide-Bonded Fusion Protein Vaccine Candidate against the Asexual and Sexual Life-Stages of the Malaria-Causing Plasmodium falciparum Parasite
Mistarz, U. H., Singh, Susheel, Nguyen, T. T. T. N., Roeffen, W., Yang, F., Lissau, C., Madsen, S. M., Vrang, A., Tiendrebeogo, R. W., Kana, Ikhlaq Hussain, Sauerwein, R. W., Theisen, Michael & Rand, Kasper Dyrberg, 1 sep. 2017, I: Pharmaceutical Research. 34, 9, s. 1970-1983 14 s.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
- Udgivet
A novel Pfs38 protein complex on the surface of Plasmodium falciparum blood-stage merozoites
Paul, G., Deshmukh, A., Kaur, I., Rathore, S., Dabral, S., Panda, A., Singh, Susheel, Mohmmed, A., Theisen, Michael & Malhotra, P., 16 feb. 2017, I: Malaria Journal. 16, 1, 15 s., 79.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
- Udgivet
Naturally acquired antibodies target the glutamate-rich protein on intact merozoites and predict protection against febrile malaria
Kana, Ikhlaq Hussain, Adu, B., Tiendrebeogo, R. W., Singh, Susheel, Dodoo, D. & Theisen, Michael, 15 feb. 2017, I: The Journal of Infectious Diseases. 215, 4, s. 623-630 8 s.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
- Udgivet
Antibody responses to two new Lactococcus lactis-produced recombinant Pfs48/45 and Pfs230 proteins increase with age in malaria patients living in the Central Region of Ghana
Acquah, F. K., Obboh, E. K., Asare, K., Boampong, J. N., Nuvor, S. V., Singh, Susheel, Theisen, Michael, Williamson, K. C. & Amoah, L. E., 2017, I: Malaria Journal. 16, 11 s., 306.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
- Udgivet
Construct design, production, and characterization of Plasmodium falciparum 48/45 R0.6C subunit protein produced in Lactococcus lactis as candidate vaccine
Singh, Susheel, Roeffen, W., Mistarz, U. H., Chourasia, B. K., Yang, F., Rand, Kasper Dyrberg, Sauerwein, R. W. & Theisen, Michael, 2017, I: Microbial Cell Factories. 16, 1, 11 s., 97.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
- Udgivet
Improving the malaria transmission-blocking activity of a Plasmodium falciparum 48/45 based vaccine antigen by SpyTag/SpyCatcher mediated virus-like display
Singh, Susheel, Thrane, Susan, Janitzek, C. M., Nielsen, Morten Agertoug, Theander, Thor Grundtvig, Theisen, Michael, Salanti, Ali & Sander, A. F., 2017, I: Vaccine. 35, 30, s. 3726-3732 7 s.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
- Udgivet
Natural antibody responses to Plasmodium falciparum MSP3 and GLURP(R0) antigens are associated with low parasite densities in malaria patients living in the Central Region of Ghana
Amoah, L. E., Nuvor, S. V., Obboh, E. K., Acquah, F. K., Asare, K., Singh, Susheel, Boampong, J. N., Theisen, Michael & Williamson, K. C., 2017, I: Parasites and Vectors. 10, 1, 9 s., 395.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
- Udgivet
Synthetic TLR4 agonists enhance functional antibodies and CD4+ T-cell responses against the Plasmodium falciparum GMZ2.6C multi-stage vaccine antigen
Baldwin, S. L., Roeffen, W., Singh, Susheel, Tiendrebeogo, R. W., Christiansen, M., Beebe, E., Carter, D., Fox, C. B., Howard, R. F., Reed, S. G., Sauerwein, R. & Theisen, Michael, 27 apr. 2016, I: Vaccine. 34, 19, s. 2207-2215 9 s.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
- Udgivet
Controlled synthesis, bioimaging and toxicity assessments in strong red emitting Mn2+ doped NaYF4:Yb3+/Ho3+ nanophosphors
Reddy, K. L., Rai, M., Prabhakar, N., Arppe, R., Rai, S. B., Singh, Susheel, Rosenholm, J. M. & Krishnan, V., 2016, I: RSC Advances. 6, 59, s. 53698-53704 7 s.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
- Udgivet
A Plasmodium falciparum 48/45 single epitope R0.6C subunit protein elicits high levels of transmission blocking antibodies
Singh, Susheel, Roeffen, W., Andersen, G., Bousema, T., Christiansen, M., Sauerwein, R. & Theisen, Michael, 15 apr. 2015, I: Vaccine. 33, 16, s. 1981-6 6 s.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
- Udgivet
Antibody-dependent cellular inhibition is associated with reduced risk against febrile malaria in a longitudinal cohort study involving Ghanaian children
Tiendrebeogo, R. W., Adu, B., Singh, Susheel, Dziegiel, Morten Hanefeld, Nébié, I., Sirima, S. B., Christiansen, M., Dodoo, D. & Theisen, Michael, 2015, I: Open forum in Infectious Diseases. 2, 2, 5 s., ofv044.Publikation: Bidrag til tidsskrift › Letter › Forskning › fagfællebedømt
- Udgivet
A multi-stage malaria vaccine candidate targeting both transmission and asexual parasite life-cycle stages
Theisen, Michael, Roeffen, W., Singh, Susheel, Andersen, G., Amoah, L., van de Vegte-Bolmer, M., Arens, T., Tiendrebeogo, R. W., Jones, S., Bousema, T., Adu, B., Dziegiel, Morten Hanefeld, Christiansen, M. & Sauerwein, R., 2014, I: Vaccine. 32, 22, s. 2623–2630 8 s.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
- Udgivet
High-throughput tri-colour flow cytometry technique to assess Plasmodium falciparum parasitaemia in bioassays
Tiendrebeogo, R. W., Adu, B., Singh, Susheel, Dodoo, D., Dziegiel, Morten Hanefeld, Mordmüller, B., Nébié, I., Sirima, S. B., Christiansen, M. & Theisen, Michael, 2014, I: Malaria Journal. 13, 1, s. 412Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
- Udgivet
The Malaria Vaccine Candidate GMZ2 Elicits Functional Antibodies in Individuals From Malaria Endemic and Non-Endemic Areas
Jepsen, M. P. G., Jogdand, P. S., Singh, Susheel, Esen, M., Christiansen, M., Issifou, S., Hounkpatin, A. B., Ateba-Ngoa, U., Kremsner, P. G., Dziegiel, Morten Hanefeld, Olesen-Larsen, S., Jepsen, S., Mordmüller, B. & Theisen, Michael, aug. 2013, I: The Journal of Infectious Diseases. 208, 3, s. 479-88 10 s.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
- Udgivet
Flow cytometric readout based on Mitotracker Red CMXRos staining of live asexual blood stage malarial parasites reliably assesses antibody dependent cellular inhibition
Jogdand, P. S., Singh, Susheel, Christiansen, M., Dziegiel, Morten Hanefeld, Singh, S. & Theisen, Michael, 2012, I: Malaria Journal. 11, 1, s. 235Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
ID: 33608855
Flest downloads
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245
downloads
Natural antibody responses to Plasmodium falciparum MSP3 and GLURP(R0) antigens are associated with low parasite densities in malaria patients living in the Central Region of Ghana
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Udgivet -
170
downloads
Construct design, production, and characterization of Plasmodium falciparum 48/45 R0.6C subunit protein produced in Lactococcus lactis as candidate vaccine
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Udgivet -
148
downloads
Capsid-like particles decorated with the SARS-CoV-2 receptor-binding domain elicit strong virus neutralization activity
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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