Susheel Singh

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Aktuel forskning

• Development of multi-stage (asexual and sexual) malaria vaccine candidate.
• VLP technology as a vaccine delivery system.
• Apply the VLP-based antigen delivery platform to produce combination malaria vaccine (using promising antigen targets from liver stage, blood stage and transmission blocking stage).
• Use the VLP-based antigen delivery platform to produce combination vaccine against Japanese Encephalitis Virus (JEV) (using the Envelope protein from major prevalent genotypes and transmission blocking: mosGCTL-7, a C-type lectin protein which plays crucial role in JEV transmission).
• Parasitic genotyping, production of antigens for immunization in small rodents and serological studies.
• Developing robust and reliable bioassays for assessing the efficacy of vaccine clinical trials.

Udvalgte publikationer

1. Udgivet

   Unravelling the immune signature of Plasmodium falciparum transmission-reducing immunity

   Stone, W. J. R., Campo, J. J., Ouédraogo, A. L., Meerstein-Kessel, L., Morlais, I., Da, D., Cohuet, A., Nsango, S., Sutherland, C. J., van de Vegte-Bolmer, M., Siebelink-Stoter, R., van Gemert, G., Graumans, W., Lanke, K., Shandling, A. D., Pablo, J. V., Teng, A. A., Jones, S., de Jong, R. M., Fabra-García, A., Bradley, J., Roeffen, W., Lasonder, E., Gremo, G., Schwarzer, E., Janse, C. J., Singh, Susheel, Theisen, Michael, Felgner, P., Marti, M., Drakeley, C., Sauerwein, R., Bousema, T. & Jore, M. M., 8 feb. 2018, I: Nature Communications. 9, 1, 14 s., 558.

   Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

2. Udgivet

   Dynamics of anti-MSP3 and Pfs230 antibody responses and multiplicity of infection in asymptomatic children from southern Ghana

   Amoah, L. E., Acquah, F. K., Ayanful-Torgby, R., Oppong, A., Abankwa, J., Obboh, E. K., Singh, Susheel & Theisen, Michael, 5 jan. 2018, I: Parasites & Vectors. 11, 1, 9 s., 13.

   Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

3. Udgivet

   Expression, Purification and Characterization of GMZ2'.10C, a Complex Disulphide-Bonded Fusion Protein Vaccine Candidate against the Asexual and Sexual Life-Stages of the Malaria-Causing Plasmodium falciparum Parasite

   Mistarz, U. H., Singh, Susheel, Nguyen, T. T. T. N., Roeffen, W., Yang, F., Lissau, C., Madsen, S. M., Vrang, A., Tiendrebeogo, R. W., Kana, Ikhlaq Hussain, Sauerwein, R. W., Theisen, Michael & Rand, Kasper Dyrberg, 1 sep. 2017, I: Pharmaceutical Research. 34, 9, s. 1970-1983 14 s.

   Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

4. Udgivet

   A novel Pfs38 protein complex on the surface of Plasmodium falciparum blood-stage merozoites

   Paul, G., Deshmukh, A., Kaur, I., Rathore, S., Dabral, S., Panda, A., Singh, Susheel, Mohmmed, A., Theisen, Michael & Malhotra, P., 16 feb. 2017, I: Malaria Journal. 16, 1, 15 s., 79.

   Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

5. Udgivet

   Naturally acquired antibodies target the glutamate-rich protein on intact merozoites and predict protection against febrile malaria

   Kana, Ikhlaq Hussain, Adu, B., Tiendrebeogo, R. W., Singh, Susheel, Dodoo, D. & Theisen, Michael, 15 feb. 2017, I: The Journal of Infectious Diseases. 215, 4, s. 623-630 8 s.

   Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

6. Udgivet

   Antibody responses to two new Lactococcus lactis-produced recombinant Pfs48/45 and Pfs230 proteins increase with age in malaria patients living in the Central Region of Ghana

   Acquah, F. K., Obboh, E. K., Asare, K., Boampong, J. N., Nuvor, S. V., Singh, Susheel, Theisen, Michael, Williamson, K. C. & Amoah, L. E., 2017, I: Malaria Journal. 16, 11 s., 306.

   Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

7. Udgivet

   Construct design, production, and characterization of Plasmodium falciparum 48/45 R0.6C subunit protein produced in Lactococcus lactis as candidate vaccine

   Singh, Susheel, Roeffen, W., Mistarz, U. H., Chourasia, B. K., Yang, F., Rand, Kasper Dyrberg, Sauerwein, R. W. & Theisen, Michael, 2017, I: Microbial Cell Factories. 16, 1, 11 s., 97.

   Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

8. Udgivet

   Improving the malaria transmission-blocking activity of a Plasmodium falciparum 48/45 based vaccine antigen by SpyTag/SpyCatcher mediated virus-like display

   Singh, Susheel, Thrane, Susan, Janitzek, C. M., Nielsen, Morten Agertoug, Theander, Thor Grundtvig, Theisen, Michael, Salanti, Ali & Sander, A. F., 2017, I: Vaccine. 35, 30, s. 3726-3732 7 s.

   Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

9. Udgivet

   Natural antibody responses to Plasmodium falciparum MSP3 and GLURP(R0) antigens are associated with low parasite densities in malaria patients living in the Central Region of Ghana

   Amoah, L. E., Nuvor, S. V., Obboh, E. K., Acquah, F. K., Asare, K., Singh, Susheel, Boampong, J. N., Theisen, Michael & Williamson, K. C., 2017, I: Parasites and Vectors. 10, 1, 9 s., 395.

   Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

10. Udgivet

    Synthetic TLR4 agonists enhance functional antibodies and CD4⁺ T-cell responses against the Plasmodium falciparum GMZ2.6C multi-stage vaccine antigen

    Baldwin, S. L., Roeffen, W., Singh, Susheel, Tiendrebeogo, R. W., Christiansen, M., Beebe, E., Carter, D., Fox, C. B., Howard, R. F., Reed, S. G., Sauerwein, R. & Theisen, Michael, 27 apr. 2016, I: Vaccine. 34, 19, s. 2207-2215 9 s.

    Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

11. Udgivet

    Controlled synthesis, bioimaging and toxicity assessments in strong red emitting Mn²⁺ doped NaYF₄:Yb³⁺/Ho³⁺ nanophosphors

    Reddy, K. L., Rai, M., Prabhakar, N., Arppe, R., Rai, S. B., Singh, Susheel, Rosenholm, J. M. & Krishnan, V., 2016, I: RSC Advances. 6, 59, s. 53698-53704 7 s.

    Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

12. Udgivet

    A Plasmodium falciparum 48/45 single epitope R0.6C subunit protein elicits high levels of transmission blocking antibodies

    Singh, Susheel, Roeffen, W., Andersen, G., Bousema, T., Christiansen, M., Sauerwein, R. & Theisen, Michael, 15 apr. 2015, I: Vaccine. 33, 16, s. 1981-6 6 s.

    Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

13. Udgivet

    Antibody-dependent cellular inhibition is associated with reduced risk against febrile malaria in a longitudinal cohort study involving Ghanaian children

    Tiendrebeogo, R. W., Adu, B., Singh, Susheel, Dziegiel, Morten Hanefeld, Nébié, I., Sirima, S. B., Christiansen, M., Dodoo, D. & Theisen, Michael, 2015, I: Open forum in Infectious Diseases. 2, 2, 5 s., ofv044.

    Publikation: Bidrag til tidsskrift › Letter › Forskning › fagfællebedømt

14. Udgivet

    A multi-stage malaria vaccine candidate targeting both transmission and asexual parasite life-cycle stages

    Theisen, Michael, Roeffen, W., Singh, Susheel, Andersen, G., Amoah, L., van de Vegte-Bolmer, M., Arens, T., Tiendrebeogo, R. W., Jones, S., Bousema, T., Adu, B., Dziegiel, Morten Hanefeld, Christiansen, M. & Sauerwein, R., 2014, I: Vaccine. 32, 22, s. 2623–2630 8 s.

    Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

15. Udgivet

    High-throughput tri-colour flow cytometry technique to assess Plasmodium falciparum parasitaemia in bioassays

    Tiendrebeogo, R. W., Adu, B., Singh, Susheel, Dodoo, D., Dziegiel, Morten Hanefeld, Mordmüller, B., Nébié, I., Sirima, S. B., Christiansen, M. & Theisen, Michael, 2014, I: Malaria Journal. 13, 1, s. 412

    Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

16. Udgivet

    The Malaria Vaccine Candidate GMZ2 Elicits Functional Antibodies in Individuals From Malaria Endemic and Non-Endemic Areas

    Jepsen, M. P. G., Jogdand, P. S., Singh, Susheel, Esen, M., Christiansen, M., Issifou, S., Hounkpatin, A. B., Ateba-Ngoa, U., Kremsner, P. G., Dziegiel, Morten Hanefeld, Olesen-Larsen, S., Jepsen, S., Mordmüller, B. & Theisen, Michael, aug. 2013, I: The Journal of Infectious Diseases. 208, 3, s. 479-88 10 s.

    Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

17. Udgivet

    Flow cytometric readout based on Mitotracker Red CMXRos staining of live asexual blood stage malarial parasites reliably assesses antibody dependent cellular inhibition

    Jogdand, P. S., Singh, Susheel, Christiansen, M., Dziegiel, Morten Hanefeld, Singh, S. & Theisen, Michael, 2012, I: Malaria Journal. 11, 1, s. 235

    Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt