Michaela Mrugala Rothová
Stem Cell and developmental Biology - early embryonic lineage specification
Blegdamsvej 3b, 2200 København N, 6.4
The aims of my research are to identify and understand the mechanism by which PI3K/Akt1 signalling modifies the Extra Cellular Matrix (ECM) composition and how the specific ECM induces the anterior character in the endoderm.
My approach is to study ES cells as a whole system, including its surrounding environment. This will enable us to understand and recapitulate in vivo development, bringing us closer to successful generation of functional cell types in vitro, such as hepatocytes and pancreatic beta cells.
This can be used therapeutically for the treatment of diseases such as diabetes and cancer and is one of the main objectives of the current research at the Danish Stem Cell Center (DanStem).