Curriculum Vitae for Kresten Lindorff-Larsen (May 2023)
Google Scholar ID: IQ59QNUAAAAJ; ORCID: 0000-0002-4750-6039; Researcher ID: K-6469-2014
07/2016 – Professor, Structural Biology and NMR Laboratory, Linderstrøm-Lang Centre for Protein Science, Department of Biology, University of Copenhagen (UCPH)
2011–16 Assoc. Prof., Structural Biology and NMR Laboratory, Dept. Bio., UCPH
2007–11 Senior Scientist, D. E. Shaw Research, New York, U.S.A.
2005–07 Assistant Professor, Department of Biochemistry, UCPH
2004–05 EMBO Research Fellow, Dept. of Protein Chem., UCPH
2001 Protein chemist, Maxygen Aps, Denmark
2001–4 Ph.D. studies at the University of Cambridge and St. John’s College, U.K. Supervisor: Sir Christopher M Dobson
1994–2000 Studies in Biochemistry (cand. scient.). UCPH.
Selected Awards and Grants
2023 ERC Synergy Grant DynaPLIX (One of three PIs)
2022 Integrative Structural Biology course—Novo Nordisk Foundation (PI)
2022 Twinning for Excellence: TWIN2PIPSA (Horizon Europe; co-PI)
2019 PRISM centre (Novo Nordisk Foundation Challenge Programme) (Director)
2019 Infrastructure for NMR and Computing (Novo Nordisk Foundation) (co-PI)
2016 BRAINSTRUC (Lundbeck Foundation initiative) (Director since 2017)
2012 Sapere Aude Starting Grant—Danish Council for Independent Research (PI)
2011 Hallas-Møller Stipend —Novo Nordisk foundation (PI)
2009 Co-recipient of the 2009 Gordon Bell Prize
2006 Danish Independent Research Councils’ Young Researchers’ Award
Selected University Administration
2013–now Head of Biocomputing Core Facility, Dept. Bio., UCPH
2015–18 Member of the Strategic Research Unit, Dept. Bio., UCPH (Chair 2017–18)
2013–18 Member of the Departmental Council, Dept. Bio., UCPH
Selected Organisational Work
2020–now Panel Member Independent Research Fund Denmark | Natural Sciences
2020–now Panel Member DeiC Science Forum and Computerome science panel
2018–2021 Panel Member ERC Advanced Grant
2011–now Grant and promotion evaluations for multiple international universities and organizations
2011–16 Founding member of the Young Academy of Denmark
2013–now Organizer of several international conferences (Berlin, Zürich, Boston)
Teaching and Supervision
2005–now Teaching and course organization at all levels in protein chemistry and biophysics
2005–now Supervisor and mentor for ca. 100 B.Sc., M.Sc., PhD students, and post docs
I am an interdisciplinary scientist and our research combines biochemistry, biophysics and structural biology to tackle fundamental problems in biology. We focus on developing and applying methods that combine experiments with computational modelling. Our research topics bridge from basic to applied science, and I have experience working both in academia and industry.
We have established a unique and highly cross-disciplinary research environment, where we currently focus on two research areas. First, we integrate molecular simulations with structural biology to study the structure and dynamics of proteins. Second, we combine high-throughput experiments and methods from cell biology with computational biophysics and data science to problems in genomic medicine. We focus on developing mechanistic models and understanding of variant effects in disease.
Our work bridges across scientific disciplines. Within the field of structural biology, we use molecular simulations to interpret biophysical experiments on protein structure and dynamics. including combining experiments and simulations to study disordered proteins. We have also helped establish approaches to link biophysics, machine learning, cell biology and genomics. Common to these areas is a drive to understand biology at the molecular level, with the goal to solve problems of practical importance.
Publications, Conferences and Outreach
- Co-author of 185 peer-reviewed scientific publications. Full list here.
- Invited speaker at >50 international conferences and ca. 50 seminars.
- Popular science articles e.g. on Parkinson’s disease (2006), genome editing (2017), effects of mutations (2021), protein structure prediction (2021) and interviews
- Popular science lectures e.g. “Mød Videnskaben” (2012; UCPH/Politiken), “DUA Peptalk” (2014; Young Academy of Denmark), “Forskningens Døgn” (2014; Royal Danish Academy of Sciences;), “Fra protein-struktur og folding til patientdiagnose” (2017; DeiC Conference)