Jakob Nilsson

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Jakob Nilsson is Associate Professor at Novo Nordisk Foundation Center for Protein Research, which he joined in 2011. Jakob did his PhD studies in the lab of Professor Jørgen Kjems, University of Aarhus, working on the small GTPase Ran. Following this, he joined Professor Poul Nissens Group, University of Aarhus, and studied structural aspects of the eukaryotic ribosome using cryo-EM. In 2005, he initiated his second Postdoc in the lab of Jonathon Pines at the Gurdon Institute, University of Cambridge, where he focused on understanding how cells accurately segregate their chromosomes during mitosis. In 2009, he was awarded the Lundbeck Foundation Junior Group Leader Fellowship to establish his own lab at BRIC, University of Copenhagen, focusing on mitotic regulation. In 2011, he moved to Novo Nordisk Foundation Center for Protein Research where he has continued his work on cell division.

Udvalgte publikationer

1. Udgivet

   A Consensus Binding Motif for the PP4 Protein Phosphatase

   Ueki, Y., Kruse, Thomas, Weisser, Melanie, Sundell, G. N., Larsen, Marie Sofie Yoo, Mendez, B. L., Jenkins, N. P., Garvanska, Dimitriya Hristoforova, Cressey, L., Zhang, G., Davey, N., Montoya, Guillermo, Ivarsson, Y., Kettenbach, A. N. & Nilsson, Jakob, 2019, I: Molecular Cell. 76, 6, s. 953-964.e6

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2. Udgivet

   Efficient mitotic checkpoint signaling depends on integrated activities of Bub1 and the RZZ complex

   Zhang, G., Kruse, Thomas, Guasch Boldú, C., Garvanska, Dimitriya Hristoforova, Coscia, F., Mann, Matthias, Barisic, Marin & Nilsson, Jakob, 2019, I: E M B O Journal. 38, 7, e100977.

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3. Udgivet

   The Ebola Virus Nucleoprotein Recruits the Host PP2A-B56 Phosphatase to Activate Transcriptional Support Activity of VP30

   Kruse, Thomas, Biedenkopf, N., Hertz, Emil Peter Thrane, Dietzel, E., Stalmann, G., López-Méndez, B., Davey, N. E., Nilsson, Jakob & Becker, S., 4 jan. 2018, I: Molecular Cell. 69, 1, s. 136-145 10 s.

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4. Udgivet

   Bub1 positions Mad1 close to KNL1 MELT repeats to promote checkpoint signalling

   Zhang, G., Kruse, Thomas, López-Méndez, B., Sylvestersen, K. B., Garvanska, Dimitriya Hristoforova, Schopper, S., Nielsen, Michael Lund & Nilsson, Jakob, 12 jun. 2017, I: Nature Communications. 8, 12 s., 15822.

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5. Udgivet

   Distinct kinetics of serine and threonine dephosphorylation are essential for mitosis

   Hein, J. B., Hertz, Emil Peter Thrane, Garvanska, Dimitriya Hristoforova, Kruse, Thomas & Nilsson, Jakob, 2017, I: Nature Cell Biology. 19, s. 1433-1440

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6. Udgivet

   A Conserved Motif Provides Binding Specificity to the PP2A-B56 Phosphatase

   Hertz, Emil Peter Thrane, Kruse, Thomas, Davey, N. E., López-Méndez, B., Sigurdsson, J. O., Montoya, Guillermo, Olsen, Jesper Velgaard & Nilsson, Jakob, 2016, I: Molecular Cell. 63, 4, s. 686-695 10 s.

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7. Udgivet

   Two functionally distinct kinetochore pools of BubR1 ensure accurate chromosome segregation

   Zhang, G., Mendez, B. L., Sedgwick, G. G. & Nilsson, Jakob, 2016, I: Nature Communications. 7, s. 1-12 12 s., 12256.

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