Guido Keijzers
Adjunkt
Molecular Aging Program
Blegdamsvej 3
2200 København N.
Research focus
Survival of organisms is highly depended on the stability of mitochondrial and genomic DNA, maintained by DNA repair proteins. Deficiencies in DNA repair genes or impairment in expression level can cause increased risk of cancer as well as aging related diseases. DNA repair pathways; namely base excision repair (BER), mismatch repair (MMR), nucleotide excision repair (NER) and non-homologous end-joining (NHEJ) are strongly associated with the aging process and aging related diseases. Deficiencies in DNA repair genes can lead to accumulation of DNA lesions, especially after exposure to DNA damaging reagents. Unrepaired DNA is postulated to be an underlying cause of neurodegenerative diseases, such as Alzheimer’s disease (AD) and Huntington’s disease (HD).
ID: 13563035
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Human DNA polymerase delta double-mutant D316A;E318A interferes with DNA mismatch repair in vitro
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RECQL4 Promotes DNA End Resection in Repair of DNA Double-Strand Breaks
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Human exonuclease 1 (EXO1) regulatory functions in DNA replication with putative roles in cancer
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