The probability and chromosomal extent of trans-specific polymorphism
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The probability and chromosomal extent of trans-specific polymorphism. / Wiuf, Carsten; Zhao, Keyan; Innan, Hideki; Nordborg, Magnus.
In: Genetics, Vol. 168, No. 4, 01.12.2004, p. 2363-2372.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - The probability and chromosomal extent of trans-specific polymorphism
AU - Wiuf, Carsten
AU - Zhao, Keyan
AU - Innan, Hideki
AU - Nordborg, Magnus
PY - 2004/12/1
Y1 - 2004/12/1
N2 - Balancing selection may result in tans-specific polymorphism: the maintenance of allelic classes that transcend species boundaries by virtue of being more ancient than the species themselves. At the selected site, gene genealogies are expected not to reflect the species tree. Because of linkage, the same will be true for part of the surrounding chromosomal region. Here we obtain various approximations for the distribution of the length of this region and discuss the practical implications of our results. Our main finding is that the trans-specific region surrounding a single-locus balanced polymorphism is expected to be quite short, probably too short to be readily detectable. Thus lack of obvious trans-specific polymorphism should not be taken as evidence against balancing selection. When trans-specific polymorphism is obvious, on the other hand, it may be reasonable to argue that selection must be acting on multiple sites or that recombination is suppressed in the surrounding region.
AB - Balancing selection may result in tans-specific polymorphism: the maintenance of allelic classes that transcend species boundaries by virtue of being more ancient than the species themselves. At the selected site, gene genealogies are expected not to reflect the species tree. Because of linkage, the same will be true for part of the surrounding chromosomal region. Here we obtain various approximations for the distribution of the length of this region and discuss the practical implications of our results. Our main finding is that the trans-specific region surrounding a single-locus balanced polymorphism is expected to be quite short, probably too short to be readily detectable. Thus lack of obvious trans-specific polymorphism should not be taken as evidence against balancing selection. When trans-specific polymorphism is obvious, on the other hand, it may be reasonable to argue that selection must be acting on multiple sites or that recombination is suppressed in the surrounding region.
UR - http://www.scopus.com/inward/record.url?scp=11244317152&partnerID=8YFLogxK
U2 - 10.1534/genetics.104.029488
DO - 10.1534/genetics.104.029488
M3 - Journal article
C2 - 15371365
AN - SCOPUS:11244317152
VL - 168
SP - 2363
EP - 2372
JO - Genetics
JF - Genetics
SN - 1943-2631
IS - 4
ER -
ID: 203902591